Characteristics and risk factors of acetaminophen-induced hepatitis in Taiwan

Chinese Medical Journal (Taipei)

Volumn 62, Issue 6, 1999, Pages 369-375

  Wang, Kelly ^a   Huang, Yi Shin ^a   Deng, Jou Fang ^a,b   Yang, Chen Chang ^a,b   Ger, Jiin ^a,b   Tsai, Wei Jen ^a,b   Wu, Jaw Ching ^a   Chao, Yee ^a   Chang, Full Young ^a   Lee, Shou Dong ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Acetaminophen; Alcohol; Overdose; Paracetamol; Toxic hepatitis

Indexed keywords

PARACETAMOL;

ADULT; ALCOHOL CONSUMPTION; ANALGESIA; ARTICLE; DRUG MEGADOSE; EARLY DIAGNOSIS; ENZYME BLOOD LEVEL; FEMALE; HEPATITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; SUICIDE ATTEMPT; TAIWAN;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; FEMALE; HEPATITIS, TOXIC; HUMANS; MALE; OVERDOSE; RISK FACTORS; SUICIDE, ATTEMPTED;

EID: 6544293462     PISSN: 05781337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Insel PA. Analgesic-antipyretics and anti-inflammatory agents: drugs employed in the treatment of rheumatoid arthritis and gout. In: Goodman Gilman AG, Rail TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. New York: Pergamon, 1990:638-81.
2. Black M. Acetaminophen hepatotoxicity. Gastroenterology 1984;78:382-92.
3. Smikstein MJ, Knapp GL, Kulig KW, Rumack BH Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National Multicenter Study (1976-1985). New Engl J Med 1988;319:1557-62.
4. Brotodihardjo A, Batey RG, Farrell GC, Byth K. Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge. Med J Aust 1992;157:382-5.
5. Rumack BH, Peterson RG. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics 1978;62(Suppl):893-903.
6. Proudfoot AT, Wright N. Acute paracetamol poisoning. Br Med J 1970;3:557-8.
7. Read RB, Tredger JM, Williams. Analysis of factors responsible for the continuing mortality after paracetamol overdose. Hum Toxicol 1986;5:201-6.
8. Keays R, Harrison PM, Wendon JA, Forbes A, Gove C, Alexander GJM, Williams R. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective trial. Br Med J 1991;303:1026-9.
9. Danan G, Benichou C. Causality assessment of adverse reactions of drugs. I. A novel method based on the conclusions of international consensus meeting: application to drug-induced liver injury. J Clin Epidemiol 1993;46: 1323-30.
10. Breen KJ, Bury R, Desmond PV, Forge BHR, Mashford ML, Whelan G. Paracetamol self-poisoning. Diagnosis, management, and outcome. Med J Aust 1982;1:77-9.
11. Meredith TJ, Newman B, Goulding R. Paracetamol poisoning in children. Br Med J 1978;2:478-9.
12. Linden CH, Rumack BH. Acetaminophen overdose. Emerg Med Clin North Am 1984;2:103-19.
13. Penna A, Buchanan N. Paracetamol poisoning in children and hepatotoxicity. Br J Pharmacol 1991;32:143-9.
14. McClain CJ, Kromhout JP, Peterson FJ, Hortman JL. Potentiation of acetaminophen hepatotoxicity by alcohol. J Am Med Inform Assoc 1980;244:251-3.
15. Maddrey WC. Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics. J Clin Gastroenterol 1987;2: 180-5.
16. Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-7.
17. Prescott LF. Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs 1983;25: 290-314.
18. Rumack BH, Peterson RG, Koch GG, Amara LA. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981;141: 380-5.
19. McElhatton PR, Sullivan FM, Volans GN. Paracetamol overdose in pregnancy: analysis of the outcome of 300 cases referred to Teratology Information Service. Reprod Toxicol 1997;11:85-94.
20. Lesser PB, Vietti MM, Clark WD. Lethal enhancement of therapeutic doses of acetaminophen by alcohol. Dig Dis Sci 1986;31:103-5.
21. Seeff LB, Cucherini BA, Zimmerman HJ, Adler E, Benjamin SB. Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. Ann Intern Med 1986;104:399-404.