The therapeutic potential for targetting potassium channels: Are dendrotoxins a suitable basis for drug design?

Perspectives in Drug Discovery and Design

Volumn 15-16, Issue , 1999, Pages 281-294

  Harvey, Alan L ^a   Dufton, Mark J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Dendrotoxins; Drug design; Potassium channels; Protein structure; Trypsin inhibitors

Indexed keywords

4 AMINOPYRIDINE; CHARYBDOTOXIN; DENDROTOXIN; MARGATOXIN; POTASSIUM CHANNEL; TRYPSIN INHIBITOR; VOLTAGE GATED CHANNEL FORMING PROTEIN;

BARTTER SYNDROME; CHANNEL GATING; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG STRUCTURE; EPILEPSY; FAMILIAL DISEASE; HEREDITARY ATAXIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN HYPOGLYCEMIA; LONG QT SYNDROME; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; MOLECULAR CLONING; MYOKYMIA; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; REVIEW; SEIZURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXIN ANALYSIS;

EID: 6544263752     PISSN: 09282866     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017001231675     Document Type: Review

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