Better outcome of Schizophrenia in India: A natural selection against severe forms?

Schizophrenia Bulletin

Volumn 35, Issue 3, 2009, Pages 655-657

  Thirthalli, Jagadisha ^a   Jain, Sanjeev ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Epigenetics; Famine; Phenotype

Indexed keywords

ARTICLE; DISEASE SEVERITY; EPIGENETICS; HUMAN; HUNGER; INDIA; MENTAL DISEASE; MORTALITY; NATURAL SELECTION; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA;

CENSUSES; CROSS-SECTIONAL STUDIES; DEVELOPING COUNTRIES; EPIGENESIS, GENETIC; HUMANS; INDIA; OUTCOME ASSESSMENT (HEALTH CARE); PHENOTYPE; SCHIZOPHRENIA; SELECTION (GENETICS); SOCIAL ENVIRONMENT; STARVATION;

EID: 65349193405     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbn012     Document Type: Article

References (26)

1. WHO 1979 Schizophrenia: An International Follow-up Study Chichester, UK: John Wiley and Sons.
2. Jablensky A, Sartorius N, Ernberg G, et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl. 1992;20:1-97.
3. Cohen A, Patel V, Thara R, Gureje O. Questioning an axiom: better prognosis for schizophrenia in the developing world? Schizophr Bull. 2007;34:229-244.
4. Isaac M, Chand P, Murthy P. Schizophrenia outcome measures in the wider international community. Br J Psychiatry Suppl. 2007;50:s71-s77.
5. Wig NN. Keynote address. In: KulharaP,Avasthi A, Verma S, eds. Schizophrenia-Indian Scene. Mumbai, India: Searle (India); 1997.
6. Harrison G, Hopper K, Craig T, et al. Recovery from psychotic illness: a 15-and 25-year international follow-up study. Br J Psychiatry. 2001;178:506-517.
7. McGlashan TH. At issue: is natural selection rendering schizophrenia less severe? Schizophr Bull. 2006;32:428-429.
8. Waterfield H. Memorandum on the Census of British India 1871-72. London, UK: Eyre and Spottiswoode; 1875.
9. Rice, BL. Census of India 1871-1872; Supplement: appendices A to H. Mysore, India: Mysore Government Press; 1875.
10. Plowden W. Report on the Census of British India taken on the 17th February 1881. London, UK: Eyre and Spottiswoode; 1883.
11. Rice BL. Report on the Mysore census. Bangalore, India: Mysore Government Press; 1884.
12. Houston SG, Annual Report of Special Hospitals in Mysore. NIMHANS Archives; 1877.
13. Baines JA. General Report on the Census of India, 1891. London, UK: Her Majesty's Stationery Office; 1893.
14. Risley HH, Gait EA. Report on the Census of India, 1901. Calcutta, India: Superintendent of Government Printing; 1903.
15. Bhatia BM. Famines in India: A study in Some Aspects of the Economic History of India With Special Reference to Food Problem. Delhi, India: Konark Publishers Pvt Ltd; 1985.
16. Ran M, Xiang M, Huang M, Shan Y. Natural course of schizophrenia: 2-year follow-up study in a rural Chinese community. Br J Psychiatry. 2001;178:154-158.
17. Murthy GVS, Janakiramaiah N, Gangadhar BN, Subbakrishna DK. Sex difference in age at onset of schizophrenia: discrepant findings from India. Acta Psychiatr Scand. 1998;97:321-325.
18. Venkatesh BK, Thirthalli J, Naveen MN, et al. Sex difference in age of onset of schizophrenia: findings from a community-based study in India. World Psychiatry. In press.
19. Susser E, Neugebauer R, Hoek HW, et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996;53:25-31.
20. St Clair D, Xu M, Wang P, et al. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005;294:557-562.
21. Ruiz-Narvaez E. Is the Ala12 variant of the PPARG gene an "unthrifty allele"? J Med Genet. 2005;42:547-550.
22. Radha V, Vimaleswaran KS, Babu HN, et al. Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: evidence for heterogeneity. Diabetes Care. 2006;29:1046-1051.
23. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007;8:253-262.
24. Haygood R, Fedrigo O,Hanson B, Yokoyama KD, Wray GA. Promoter regions of many neural-and nutrition-related genes have experienced positive selection during human evolution. Nat Genet. 2007;39:1140-1144.
25. Perry GH, Dominy NJ, Claw KG, et al. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007;39:1256-1260.
26. Single RM, Martin MP, Gao X, et al. Global diversity and evidence for coevolution of KIR and HLA. Nat Genet. 2007;39:1114-1119.