Glucose-6-phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: A cross-sectional survey in the Brazilian Amazon

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Santana, Marli Stela ^a   de Lacerda, Marcus Vinícius Guimarães ^a,b,c   Barbosa, Maria Das Graças Vale ^a,b,c   Duarte Alecrim, Wilson ^b,c   Costa Alecrim, Maria Das Graças ^a,c  

^a UNIVERSIDADE DO ESTADO DO AMAZONAS   (Brazil)

^b Tropical Medicine Foundation of Amazonas   (Brazil)

^c UNIVERSIDADE NILTON LINS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD TRANSFUSION; BRAZIL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENDEMIC DISEASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HUMAN; JAUNDICE; MALARIA; MALE; PLASMODIUM VIVAX; PREVALENCE; ADOLESCENT; ADULT; AGED; CHILD; GENETICS; IMMUNITY; INFANT; MIDDLE AGED; PLASMODIUM VIVAX MALARIA; PRESCHOOL CHILD; RISK; STATISTICAL MODEL; X CHROMOSOME LINKED DISORDER;

PLASMODIUM VIVAX;

ANTIMALARIAL AGENT; GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ADOLESCENT; ADULT; AGED; ANTIMALARIALS; BLOOD TRANSFUSION; BRAZIL; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ENDEMIC DISEASES; GENETIC DISEASES, X-LINKED; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HUMANS; IMMUNITY; INFANT; JAUNDICE; LOGISTIC MODELS; MALARIA, VIVAX; MALE; MIDDLE AGED; ODDS RATIO; YOUNG ADULT;

EID: 65349186504     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005259     Document Type: Article

References (30)

1. World Health Organization (2008) World Health Report. Available: http://www.who.int/whr/en/index.html. Accessed 2008 Dec 10.
2. Brazilian Ministry of Health (2006) Epidemiological Bulletin of Malaria (SIVEP). Available: http://www.saude.gov.br_sivep. Accessed 2007 Jun 20.
3. Alecrim MGC, Alecrim WD, Macedo V (1999) Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region. Rev Soc Bras Med Trop 32: 67-68.
4. Gonçalves MJF, Alecrim WD (2004) Non-planed urbanization as a contributing factor for malaria incidence in Manaus-Amazonas, Brazil. Rev Salud Publica (Bogota) 6: 156-166.
5. FUNASA (2001) Malaria Therapeutics Guidelines. Brasília: National Foundation of Health, Brazilian Ministry of Health.
6. Beutler E, Duparc S (2007) G6PD Deficiency Working Group. Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg 77: 779-789.
7. Luzzatto L, Mehta A, Meloni T (1995) Haemoglobinuria and haptoglobin in G6PD deficiency. Br J Haematol 91: 511-512.
8. Santana MS, Arcanjo ARL, Rocha MAF, Sardinha JFJ, Alecrim WD, et al. (2007) Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine. Rev Soc Bras Med Trop 40: 533-536.
9. Beutler E, Vulliamy TJ (2002) Hematologically important mutations: glucose-6-phosphate dehydrogenase. Blood Cells Mol Dis 28: 93-103.
10. Yoshida A, Beutler E, Motulsky AG (1971) Human glucose-6-phosphate dehydrogenase variants. Bull World Health Organ 45: 243-253.
11. Badens C, Martinez di Montemuros F, Thuret I, Michel G, Mattei JF, et al. (2000) Molecular basis of haemoglobinopathies and G6PD deficiency in the Comorian population. Hematol J 1: 264-268.
12. De Araujo C, Migot-Nabias F, Guitard J, Pelleau S, Vulliamy T, et al. (2006) The role of the G6PD AEth376G/968C allele in glucose-6-phosphate dehydrogenase deficiency in the seerer population of Senegal. Haematologica 91: 262-263.
13. Iwai K, Hirono A, Matsuoka H, Kawamoto F, Horie T, et al. (2001) Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia. Hum Genet 108: 445-449.
14. Louicharoen C, Nuchprayoon I (2005) G6PD Viangchan (871G>A) is the most common G6PD-deficient variant in the Cambodian population. J Hum Genet 50: 448-452.
15. Sukumar S, Mukherjee MB, Colah RB, Mohanty D (2004) Molecular basis of G6PD deficiency in India. Blood Cells Mol Dis 33: 141-145.
16. Al-Riyami A, Ebrahim GJ (2003) Genetic Blood Disorders Survey in the Sultanate of Oman. J Trop Pediatr 49: 1-20.
17. Usanga EA, Ameen R (2000) Glucose-6-phosphate dehydrogenase deficiency in Kuwait, Syria, Egypt, Iran, Jordan and Lebanon. Hum Hered 50: 158-61.
18. Weimer TA, Salzano FM, Westwood B, Beutler E (1993) Molecular characterization of glucose-6-phosphate dehydrogenase variants from Brazil. Hum Biol 65: 41-47.
19. Saad ST, Salles TS, Carvalho MH, Costa FF (1997) Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Brazil. Hum Hered 47: 17-21.
20. Compri MB, Saad ST, Ramalho AS (2000) Genetic-epidemiological and molecular investigation of G-6-PD deficiency in a Brazilian community. Cad Saúde Pública 16: 335-342.
21. Castro S, Weber R, Dadalt V, Tavares V, Giugliani R (2006) Prevalence of G6PD deficiency in newborns in the south of Brazil. J Med Screen 13: 85-86.
22. Hamel AR, Cabral IR, Sales TS, Costa FF, Saad STO (2002) Molecular heterogeneity of G6PD deficiency in an Amazonian population and description of four new variants. Blood Cells Mol Dis 28: 399-406.
23. Silva MC, Santos EB, Costal EG, Filho MG, Guerreiro JF, et al. (2004) Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50 mg/kg/day. Rev Soc Bras Med Trop 37: 215-217.
24. Greene LS, McMahon L, DiIorio J (1993) Co-evolution of glucose-6-phosphate dehydrogenase deficiency and quinine taste sensitivity. Ann Hum Biol 20: 497-500.
25. Guindo A, Fairhurst RM, Doumbo OK, Wellems TE, Diallo DA (2007) XLinked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Med 4: e66. doi:10.1371/journal. pmed.0040066.
26. Roth EF Jr, Raventos-Suarez C, Rinaldi A, Nagel RL (1983) Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci USA 80: 298-299.
27. Lacerda MVG, Zackiewicz C, Alecrim WD, Alecrim MGC (2007) The neglected Plasmodium vivax: are researchers from endemic areas really concerned about new treatment options? Rev Soc Bras Med Trop 40: 489-90.
28. Brewer GJ, Tarlov AR, Alving AS (1962) The methaemoglobin reduction test for primaquine-type sensitivity of erythrocytes. A simplified procedure for detecting a specific hypersusceptibility to drug haemolysis. JAMA 180: 386-388.
29. Forbes J, Steytler JG, van Heerden R (1991) Agarose gel electrophoresis of glucose-6-phosphate-dehydrogenase isoenzymes. Clin Chim Acta 199: 279-282.
30. World Health Organization (1975) Microscopic Diagnosis of Malaria, 4th edition. iugliani R (2006). Prevalence of G6PD deficiency in newborns in the south of Brazil. J Med Screen 13: 85-86.