The association of D-dimer levels with clinical outcomes in patients presenting with acute pulmonary embolism

Laboratory Hematology

Volumn 15, Issue 1, 2009, Pages 4-9

  Blamoun, John ^a,b   Alfakir, Maria ^a   Sedfawy, Ashraf I R ^a   Moammar, Mahmoud Q ^a,b   Maroules, Michael ^a,b   Khan, M Anees ^a,b   Debari, Vincent A ^a,b  

^a ST JOSEPH S REGIONAL MEDICAL CENTER   (United States)

^b SETON HALL UNIVERSITY   (United States)

Author keywords

D dimer; Fibrinolysis; Outcomes; Pulmonary embolism; Thrombosis

Indexed keywords

D DIMER; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

ADULT; ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; FEMALE; FIBRINOLYSIS; HAZARD RATIO; HUMAN; LUNG ALVEOLUS OXYGEN TENSION; LUNG EMBOLISM; LUNG VENTILATION PERFUSION RATIO; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; RECURRENT DISEASE; VENOUS THROMBOEMBOLISM; ACUTE DISEASE; LONGITUDINAL STUDY; LUNG FUNCTION TEST; TOMOGRAPHY; TREATMENT OUTCOME;

ACUTE DISEASE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HOSPITAL MORTALITY; HUMANS; LONGITUDINAL STUDIES; PROGNOSIS; PULMONARY EMBOLISM; RECURRENCE; RESPIRATORY FUNCTION TESTS; TOMOGRAPHY; TREATMENT OUTCOME;

EID: 65349182938     PISSN: 10802924     EISSN: None     Source Type: Journal    
DOI: 10.1532/LH96.08014     Document Type: Article

References (27)

1. Devine DV, Greenberg CS. Monoclonal antibody to fibrin D-dimer (DD-3B6) recognizes an epitope on the gamma-chain of fragment D. Am J Clin Pathol. 1988;89:663-666.
2. Gaffney PJ, Joe F. The lysis of crosslinked human fibrin by plasmin yields initially a single molecular complex, D-dimer-E. Thromb Res. 1979;15:673-687.
3. Righini M, Perrier A, De Moerloose P, Bounameaux H. D-dimer for venous thromboembolism diagnosis: 20 years later. J Thromb Hemost. 2008;6:1059-1071.
4. Aujesky D, Hayoz D, Yersin B, et al. Exclusion of pulmonary embolism using C-reactive protein and D-dimer: a prospective comparison. Thromb Haemost. 2003;90:1198-1203.
5. Frost SD, Brotman DJ, Michota FA. Rational use of D-dimer measurement to exclude acute venous thromboembolic disease. Mayo Clin Proc. 2003;78:1385-1391.
6. Kruip MJ, Leclercq MG, van der Heul C, Prins MH, Büller HR. Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies: a systematic review. Ann Intern Med. 2003;138:941-951.
7. Hargett CW, Tapson VF. Clinical probability and D-dimer testing: how should we use them in clinical practice? Semin Respir Crit Care Med. 2008;29:15-24.
8. Hochuli M, Duewell S, Frauchiger B. Quantitative D-dimer levels and the extent of venous thromboembolism in CT angiography and lower limb ultrasonography. Vasa. 2007;36:267-274.
9. Qanadli SD, El Hajjam M, Viellard-Baron A, et al. New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. AJR Am J Roentgenol. 2001;176:1415-1420.
10. Metafratzi ZM, Vassiliou MP, Maglaras GC, et al. Acute pulmonary embolism: correlation of CT pulmonary artery obstruction index with blood gas values. AJR Am J Roentgenol. 2006;186:213-219.
11. DeBari VA. Computation of decision levels from differentiated logistic regression probability curves. Ann Clin Lab Sci. 2006;36:194-200.
12. Stein PD, Sostman HD, Bounameaux H, et al. Challenges in the diagnosis of acute pulmonary embolism. Am J Med. 2008;121:565-571
13. Brotman DJ, Segal JB, Jani JT, Petty BG, Kickler TS. Limitations of D-dimer testing in unselected inpatients with suspected venous thromboembolism. Am J Med. 2003;114:276-282.
14. Kabbara R, Labarere J, Pernod G, Bosson JL. D-dimer level is not a prognostic biomarker specific for pulmonary embolism. Crit Care Med. 2008;36:652-653.
15. Wells PS, Ginsberg JS, Anderson DR, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997-1005.
16. Wells PS, Anderson DR, Rodger M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with SimpliRED D-dimer. Thromb Haemost. 2000;83:416-420.
17. Gibson NS, Sohne M, Kruip MJ, et al. Further validation and simplification of the Wells clinical decision rule in pulmonary embolism. Thromb Haemost. 2008;99:229-234.
18. Goldin Y, Berliner S, Rogowski O, et al. Correlated expression of D-dimer concentrations with thrombotic burden in acute pulmonary embolism. Blood Coagul Fibrinolysis. 2008;19:153-158.
19. Galle C, Papazyan JP, Miron MJ, Slosman D, Bounameaux H, Perrier A. Prediction of pulmonary embolism extent by clinical findings, D-dimer level and deep vein thrombosis shown by ultrasound. Thromb Haemost. 2001;86:1156-1160.
20. Grau E, Tenías JM, Soto MJ, et al. D-dimer levels correlate with mortality in patients with acute pulmonary embolism: findings from the RIETE registry. Crit Care Med. 2007;35:1937-1941.
21. Klok FA, Djurabi RK, Nijkeuter M, et al. High D-dimer level is associated with increased 15-d and 3 months mortality through a more central localization of pulmonary emboli and serious comorbidity. Br J Haematol. 2007;140:218-222.
22. Bounameaux H, de Moerloose P, Perrier A, Miron MJ. D-dimer testing in suspected venous thromboembolism: an update. QJM. 1997;90:437-442.
23. Reber G, Boehlen F, Bounameaux H, de Moerloose P. Performance of the AxSYM D-dimer assay for the exclusion of pulmonary embolism. J Thromb Haemost. 2007;5:2304-2305.
24. Ghanima W, Abdelnoor M, Mowinckel MC, Sandset PM. The performance of STA-Liatest D-dimer assay in out-patients with suspected pulmonary embolism. Br J Haematol. 2006;132:210-215.
25. Spannagl M, Haverkate F, Reinauer H, Meijer P. The performance of quantitative D-dimer assays in laboratory routine. Blood Coagul Fibrinolysis. 2005;16:439-443.
26. Schrecengost JE, LeGallo RD, Boyd JC, et al. Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem. 2003;49:1483-1490.
27. Froehling DA, Daniels PR, Swensen SJ, et al. Evaluation of a quantitative D-dimer latex immunoassay for acute pulmonary embolism diagnosed by computed tomographic angiography. Mayo Clin Proc. 2007;82:556-560.