Adjuvant photodynamic therapy does not prevent recurrence of condylomata acuminata after carbon dioxide laser ablation - A phase III, prospective, randomized, bicentric, double-blind study

Dermatologic Surgery

Volumn 35, Issue 5, 2009, Pages 757-764

  Szeimies, Rolf Markus ^a   Schleyer, Verena ^a   Moll, Ingrid ^b   Stocker, Marcus ^c   Landthaler, Michael ^a   Karrer, Sigrid ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c MEDAC GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; CARBON DIOXIDE; PLACEBO;

ADULT; ARTICLE; CLINICAL EVALUATION; CLINICAL TRIAL; CONDYLOMA ACUMINATUM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; EDEMA; ERYTHEMA; FEMALE; HUMAN; INFECTION; LASER SURGERY; LIBIDO; MAJOR CLINICAL STUDY; MALE; PHASE 3 CLINICAL TRIAL; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SIDE EFFECT; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, TOPICAL; ADULT; CONDYLOMATA ACUMINATA; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GENITAL DISEASES, FEMALE; GENITAL DISEASES, MALE; HUMAN PAPILLOMAVIRUS 6; HUMANS; LASER THERAPY; LASERS, GAS; MALE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROSPECTIVE STUDIES; RECURRENCE; TREATMENT OUTCOME;

EID: 65349178169     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2009.01125.x     Document Type: Article

References (14)

1. Gross G, Ikenberg H, Petry KU, et al. Condylomata acuminata und andere HPV-assoziierte Krankheitsbilder von Genitale, Anus und Harnröhre. Leitlinie der Deutschen STD-Gesellschaft in Zusammenarbeit mit der Deutschen Dermatologischen Gesellschaft und der Paul-Ehrlich-Gesellschaft. Hautarzt 2007 58 : 179 86.
2. Gross G, von Krogh. Human papilloma-virus infections in Dermatovenereology. Boca Raton : CRC Press 1997.
3. Yan J, Chen SL, Wang HN, Wu TX. Meta-analysis of 5% imiquimod and 0.5% podophyllotoxin in the treatment of condylomata acuminata. Dermatology 2006 213 : 218 23. (Pubitemid 44567832)
4. Ferenczy A, Mitao M, Nagai N, et al. Latent papillomavirus and recurring genital warts. N Engl J Med 1985 313 : 784 8. (Pubitemid 15232313)
5. Fehr MK, Chapman CF, Krasieva T, et al. Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid. Am J Obstet Gynecol 1996 174 : 951 7. (Pubitemid 26398987)
6. Ross EV, Romero R, Kollias N, et al. Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5-aminolevulinic acid: implications for photodynamic treatment. Br J Dermatol 1997 137 : 736 42. (Pubitemid 27496190)
7. Von Krogh G, Lacey CJN, Gross G, et al. European course on HPV-associated pathology: guidelines for the diagnosis and management of anogenital warts. Sex Transm Inf 2000 76 : 162 8.
8. Stanley M. Prevention strategies against the human papillomavirus: the effectiveness of vaccination. Gynecol Oncol 2007 107 (1 Suppl) : S19 23. (Pubitemid 47552535)
9. Smetana Z, Malik Z, Orenstein A, et al. Treatment of viral infections with 5-aminolevulinic acid and light. Lasers Surg Med 1997 21 : 351 8. (Pubitemid 27430513)
10. Wang XL, Wang HW, Huang Z, et al. Study of protoporphyrin IX (PpIX) pharmacokinetics after topical application of 5-aminolevulinic acid in urethral condylomata acuminata. Photochem Photobiol 2007 83 : 1069 73. (Pubitemid 47438535)
11. Frank RG, Bos JD, van der Meulen FW, Sterenborg HJCM. Photodynamic therapy for condylomata acuminata with local application of 5-aminolevulinic acid. Genitourin Med 1996 72 : 70 1. (Pubitemid 26057878)
12. Stefanaki IM, Georgiou S, Themelis GC, et al. In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminate. Br J Dermatol 2003 149 : 972 6. (Pubitemid 37541981)
13. Wang XL, Wang HW, Wang HS, et al. Topical 5-aminolevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata. Br J Dermatol 2004 151 : 880 5. (Pubitemid 39482124)
14. 2 laser vaporization in treatment of condylomata acuminata: a randomized clinical trial. Br J Dermatol 2007 156 : 516 20. (Pubitemid 46253929)