Composite outcomes can distort the nature and magnitude of treatment benefits in clinical trials

Annals of Internal Medicine

Volumn 150, Issue 8, 2009, Pages 566-567

  Ferreira Gonzalez, Ignacio ^a   Permanyer Miralda, Gaieta ^a   Busse, Jason W ^b   Devereaux, P J ^b   Guyatt, Gordon H ^b   Alonso Coello, Pablo ^c   Montori, Victor M ^d  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b MCMASTER UNIVERSITY   (Canada)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL RESEARCH; LETTER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SAMPLE SIZE; HUMAN; MEDICAL RESEARCH; METHODOLOGY; NOTE; RANDOMIZED CONTROLLED TRIAL; STANDARD; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

BIOMEDICAL RESEARCH; DATA INTERPRETATION, STATISTICAL; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 65349168834     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-150-8-200904210-00016     Document Type: Letter

References (6)

1. Lim E, Brown A, Helmy A, Mussa S, Altman DG. Composite outcomes in cardiovascular research: a survey of randomized trials. Ann Intern Med. 2008;149:612-7. [PMID: 18981486]
2. Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials: greater precision but with greater uncertainty? JAMA. 2003;289: 2554-9. [PMID: 12759327]
3. Montori VM, Permanyer-Miralda G, Ferreira-Gonzalez I, Busse JW, Pacheco-Huergo V, Bryant D, et al. Validity of composite end points in clinical trials. BMJ. 2005;330:594-6. [PMID: 15761002]
4. Ferreira-Gonzalez I, Permanyer-Miralda G, Busse JW, Bryant DM, Montori VM, Alonso-Coello P, et al. Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns. J Clin Epidemiol. 2007;60: 651-7; discussion 658-62. [PMID: 17573977]
5. Ferreira-Gonzalez I, Busse JW, Heels-Ansdell D, Montori VM, Aid EA, Bryant DM, et al. Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ. 2007;334:786. [PMID: 17403713]
6. Guyatt GH, Montori VM, Ferreira-Gonzalez I, Busse JW, Schunemann HJ, Jae-schke R, et al. Composite endpoints. In: Guyatt GH, Rennie D, Meade MO, Cook DJ, eds. Users' Guides to the Medical Literature. 2nd ed. Columbus, OH: McGraw-Hill; 2008:237-48.