Stroke trials: A shift to shift analysis?

Neurology

Volumn 72, Issue 15, 2009, Pages 1292-1293

  Brown, Devin L ^a,c   Coffey, Christopher S ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c The Cardiovascular Center Stroke Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE DISEASE; DISEASE SEVERITY; EDITORIAL; NEUROPROTECTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RECANALIZATION; STROKE; CLINICAL TRIAL; HUMAN; NOTE; REPRODUCIBILITY; STATISTICAL ANALYSIS;

CLINICAL TRIALS AS TOPIC; DATA INTERPRETATION, STATISTICAL; HUMANS; REPRODUCIBILITY OF RESULTS; STROKE;

EID: 65349156288     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181a11417     Document Type: Editorial

References (7)

1. Saver JL, Gornbein J. Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology 2009;72:1310-1315.
2. Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med 2006;354:588-600.
3. The FAST-MAG Trialists. The field administration of stroke therapy-magnesium (FAST-MAG) phase 3 clinical trial. Available at: www.fastmag.info. Accessed 2008.
4. Saver JL. Number needed to treat estimates incorporating effects over the entire range of clinical outcomes: novel derivation method and application to thrombolytic therapy for acute stroke. Arch Neurol 2004;61:1066-1070.
5. Savitz SI, Lew R, Bluhmki E, Hacke W, Fisher M. Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials. Stroke 2007;38:3205-3212.
6. The Optimising Analysis of Stroke Trials (OAST) Collaboration. Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke 2007;38:1911-1915.
7. Chow SC, Chang M. Adaptive Design Methods in Clinical Trials, ch 4. Boca Raton: Chapman & Hall/CRC; 2007.