PCR-RFLP to detect codon 248 mutation in exon 7 of p53 tumor suppressor gene

Biochemistry and Molecular Biology Education

Volumn 37, Issue 2, 2009, Pages 106-109

  Liming, Ouyang ^a   Chongtao, Ge ^a   Haizhen, Wu ^a   Suxia, Li ^a   Huizhan, Zhang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Codon 248; Genomics experiment; Mutation; p53 gene; PCR RFLP

Indexed keywords

EID: 65349137077     PISSN: 14708175     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmb.20255     Document Type: Article

References (3)

1. R. G. Berkson, J. J. Hollick, N. J. Westwood, J. A. Woods, D. P. Lane, S. Lain S (2005) Pilot screening programme for small molecule activators of p53. Int. J. Cancer. 115, 701-710.
2. A. Petitjean, E. Mathe, S. Kato, C. Ishioka, S. V. Tavtigian, P. Hainaut, M. Olivier (2007) Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database. Hum. Mut. 28, 622-629.
3. D. Malkin, F. P. Li, L. C. Strong, J. F. Fraumeni, C. E. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, M. A. Tainsky, S. H. Friend (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238.