Mechanism and implication of cephalosporin penetration into oropharyngeal mucosa

Journal of Infection and Chemotherapy

Volumn 15, Issue 2, 2009, Pages 70-74

  Najjar, Tawfeeg A ^a   Alkharfy, Khalid M ^a   Saad, Sherif Y ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cefixime; Cephalexin; Mucosa; Oropharyngeal; Saliva

Indexed keywords

CEFALEXIN; CEFIXIME;

ACTIVE TRANSPORT; ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG EXCRETION; DRUG HALF LIFE; DRUG PENETRATION; HAEMOPHILUS INFLUENZAE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MECHANICS; MORAXELLA CATARRHALIS; MOUTH MUCOSA; NORMAL HUMAN; SALIVA ANALYSIS; SINGLE DRUG DOSE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 65349132081     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10156-008-0666-4     Document Type: Article

References (23)

1. F. Soriano V. Rodriguez-Cerrato 2002 Pharmacodynamic and kinetic basis for the selection of pneumococcal resistance in the upper respiratory tract J Antimicrob Chemother 50 SupplS2 51 58 (Pubitemid 36175838)
2. D. Guillemot C. Carbon B. Balkau P. Geslin H. Lecoeur F. Vauzelle-Kervroedan 1998 Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniae JAMA 279 365 370 (Pubitemid 28133865)
3. W.A. Craig 2001 Does the dose matter? Clin Infect Dis 33 Suppl3 S233 S237 (Pubitemid 32835797)
4. R.E. Siegel 1999 The significance of serum vs tissue levels of antibiotics in the treatment of penicillin-resistant Streptococcus pneumoniae and community-acquired pneumonia: are we looking in the wrong place? Chest 116 535 538 (Pubitemid 29382140)
5. D.N. Fish 2003 Bronchoscopic sampling of drug concentrations: penetration to tissue is the issue Am J Respir Crit Care Med 168 1263 1265 (Pubitemid 37487315)
6. R. Haeckel P. Hanecke 1996 Application of saliva for drug monitoring. An in vivo model for transmembrane transport Eur J Clin Chem Clin Biochem 34 171 191 (Pubitemid 126760459)
7. W.L. Risser J.S. Barone P.A. Clark D.L. Simpkins 1987 Noncomparative, open label, multicenter trial of cefixime for treatment of bacterial pharyngitis, cystitis and pneumonia in pediatric patients Pediatr Infect Dis J 6 1002 1006 (Pubitemid 17151064)
8. J.R. Casey M.E. Pichichero 2004 Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults Clin Infect Dis 38 1526 1534 (Pubitemid 38738545)
9. O'Neil JM (ed). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Whitehouse Station: John Wiley & Sons; 2001.
10. Hardman JG, Limbird LE (eds). Goodman and Gillman's pharmacologic basis of therapeutics. New York: McGraw-Hill; 2005.
11. C.Y. Chan K. Chan G.L. French 1986 Rapid high performance liquid chromatographic assay of cephalosporins in biological fluids J Antimicrob Chemother 18 537 545 (Pubitemid 17176542)
12. A.L. Barry R.N. Jones 1987 Cefixime: spectrum of antibacterial activity against 16 016 clinical isolates Pediatr Infect Dis J 6 954 957 (Pubitemid 17151055)
13. P.C. Fuchs R.N. Jones A.L. Barry C. Thornsberry L.W. Ayers T.L. Gavan 1986 In vitro evaluation of cefixime (FK027, FR17027, CL284635): spectrum against recent clinical isolates, comparative antimicrobial activity, beta-lactamase stability, and preliminary susceptibility testing criteria Diagn Microbiol Infect Dis 5 151 162 (Pubitemid 16091108)
14. A. Kumar K.J. Kelly 1988 In vitro activity of cefixime (CL284635) and other antimicrobial agents against Haemophilus isolates from pediatric patients Chemotherapy 34 30 35 (Pubitemid 18051982)
15. M. Powell D. McVey M.H. Kassim H.Y. Chen J.D. Williams 1991 Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella (Branhamella) catarrhalis isolated in the UK from sputa J Antimicrob Chemother 28 249 259
16. M. Powell J.D. Williams 1987 In vitro susceptibility of Haemophilus influenzae to cefixime Antimicrob Agents Chemother 31 1841 1842 (Pubitemid 17157654)
17. H.S. Sader M.R. Jacobs T.R. Fritsche 2007 Review of the spectrum and potency of orally administered cephalosporins and amoxicillin/clavulanate Diagn Microbiol Infect Dis 57 5S 12S (Pubitemid 46349495)
18. M.R. Jacobs D. Felmingham P.C. Appelbaum R.N. Gruneberg 2003 The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents J Antimicrob Chemother 52 229 246 (Pubitemid 36986885)
19. J.R. Casey M.E. Pichichero 2004 Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children Pediatrics 113 866 882 (Pubitemid 38437395)
20. W.A. Craig 2003 Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid Infect Dis Clin North Am 17 479 501 (Pubitemid 38029149)
21. E. Kaufman I.B. Lamster 2002 The diagnostic applications of saliva - a review Crit Rev Oral Biol Med 13 197 212
22. R.F. Vining R.A. McGinley 1986 Hormones in saliva Crit Rev Clin Lab Sci 23 95 146
23. F. Rasmussen 1964 Salivary excretion of sulphonamides and barbiturates by cows and goats Acta Pharmacol Toxicol (Copenh) 21 11 19