Impact of calcium-channel blockers on right heart function in a controlled model of chronic pulmonary hypertension

European Journal of Anaesthesiology

Volumn 26, Issue 3, 2009, Pages 253-259

  Zierer, Andreas ^a   Voeller, Rochus K ^a   Melby, Spencer J ^a   Steendijk, Paul ^b   Moon, Marc R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calcium channel blockers; Chronic pulmonary hypertension; Right heart function

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; POTASSIUM CHLORIDE; THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATHETER; CONTROLLED STUDY; DISEASE SEVERITY; DOG; DRUG EFFECT; FEMALE; HEART AFTERLOAD; HEART FUNCTION; HEART OUTPUT; HEART RIGHT ATRIUM; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE PRESSURE; HEART VOLUME; LUNG ARTERY BANDING; MALE; NONHUMAN; PULMONARY ARTERY OCCLUSION; PULMONARY HYPERTENSION; TREATMENT RESPONSE; TRICUSPID VALVE; ANIMAL; BLOOD PRESSURE; CHRONIC DISEASE; DISEASE MODEL; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HYPERTENSION, PULMONARY; MALE; VENTRICULAR FUNCTION, RIGHT;

EID: 65349130026     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e328324b631     Document Type: Article

References (32)

1. Rich S, Brundage BH. High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation 1987; 76: 135-141.
2. Packer M, Medina N, Yushak M. Adverse hemodynamic and clinical effects of calcium channel blockade in pulmonary hypertension secondary to obliterative pulmonary vascular disease. J Am Coll Cardiol 1984; 4: 890-891.
3. Badesch DB, Abman SH, Simonneau G, et al. Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines. Chest 2007; 131: 1917-1928.
4. Sitbon O, Humbert M, Jais X, et al. Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation 2005; 111: 3105-3111.
5. Sitbon O, Humbert M, Jagot JL, et al. Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension. Eur Respir J 1998; 12: 265-270.
6. Barst RJ, McGoon M, Torbicki A, et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 40S-47S.
7. Galie N, Torbicki A, Barst R, et al. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J 2004; 25: 2243-2278.
8. Kennedy T, Summer W. Inhibitionof hypoxic pulmonary vasoconstriction by nifedipine. Am J Cardiol 1982; 50: 864-868.
9. McMurtry IF, Davidson AB, Reeves JT, Grover RF. Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs. Circ Res 1976; 38: 99-104.
10. Morel OE, Buvry A, Le Corvoisier P, et al. Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat. Pflugers Arch 2003; 446: 356-364.
11. Maniar HS, Prasad SM, Gaynor SL, et al. Impact of pericardial restraint on right atrial mechanics during acute right ventricular pressure load. Am J Physiol 2003; 284: H350-H357.
12. Gaynor SL, Maniar HS, Bloch JB, et al. Right atrial and ventricular adaptation to chronic right ventricular pressure overload. Circulation 2005; 112: I212-I218.
13. Gaynor SL, Maniar HS, Prasad SM, et al. Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output. Am J Physiol 2005; 288: H2140-H2145.
14. Steendijk P, Staal E, Jukema JW, Baan J. Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter. Am J Physiol Heart Circ Physiol 2001; 281: H755-H763.
15. Hoit BD, Shao Y, Gabel M, Walsh RA. In vivo assessment of left atrial contractile performance in normal and pathological conditions using a timevarying elastance model. Circulation 1994; 89: 1829-1838.
16. Moon MR, DeAnda A, Castro LJ, et al. Effects of mechanical left ventricular support on right ventricular diastolic function. J Heart Lung Transplant 1997; 16: 398-407.
17. Moon MR, Castro LJ, DeAnda A, et al. Right ventricular dynamics during left ventricular assistance in closed-chest dogs. Ann Thorac Surg 1993; 56: 54-66.
18. Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial mechanical and biochemical adaptation to pacing induced heart failure. Cardiovasc Res 1995; 29: 469-474.
19. Grant C, Bunnell IL, Greene DG. The reservoir function of the left atrium during ventricular systole. An angiocardiographic study of atrial stroke volume and work. Am J Med 1964; 37: 36-43.
20. Hoit BD, Shao Y, Tsai LM, et al. Altered left atrial compliance after atrial appendectomy. Influence on left atrial and ventricular filling. Circ Res 1993; 72: 167-175.
21. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of pericardium on left atrial compliance and pulmonary venous flow. Am J Physiol 1993; 264: H1781-H1787.
22. Goldstein JA, Harada A, Yagi Y, et al. Hemodynamic importance of systolic ventricular interaction, augmented right atrial contractility and atrioventricular synchrony in acute right ventricular dysfunction. J Am Coll Cardiol 1990; 16: 181-189.
23. Goldstein JA, Tweddell JS, Barzilai B, et al. Right atrial ischemia exacerbates hemodynamic compromise associated with experimental right ventricular dysfunction. J Am Coll Cardiol 1991; 18: 1564-1572.
24. Mukherjee R, Spinale FG. L-type calcium channel abundance and function with cardiac hypertrophy and failure: a review. J Mol Cell Cardiol 1998; 30: 1899-1916.
25. Shirayama T, Pappano AJ. Biphasic effects of intrapipette cyclic guanosine monophosphate on L-type calcium current and contraction of guinea pig ventricular myocytes. J Pharmacol Exp Ther 1996; 279: 1274-1281.
26. Chen EP, Craig DM, Bittner HB, et al. Pharmacological strategies for improving diastolic dysfunction in the setting of chronic pulmonary hypertension. Circulation 1998; 97: 1606-1612.
27. Chen EP, Bittner HB, Tull F, et al. An adult canine model of chronic pulmonary hypertension for cardiopulmonary transplantation. J Heart Lung Transplant 1997; 16: 538-547.
28. Chouabe C, Espinosa L, Megas P, et al. Reduction of I (Ca, L) and I (to1) density in hypertrophied right ventricular cells by simulated high altitude in adult rats. J Mol Cell Cardiol 1997; 29: 193-206.
29. Hsieh CM, Mishkel GJ, Cardoso PF, et al. Production and reversibility of right ventricular hypertrophy and right heart failure in dogs. Ann Thorac Surg 1992; 54: 104-110.
30. Suga H. Importance of atrial compliance in cardiac performance. Circ Res 1974; 35: 39-43.
31. Barbier P, Solomon SB, Schiller NB, Glantz SA. Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function. Circulation 1999; 100: 427-436.
32. Wong K, Boheler KR, Petrou M, Yacoub MH. Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. Circulation 1997; 96: 2239-2246.