Development and validation of a sensitive LCMS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 23, Issue 2, 2009, Pages 212-218

  Bharathi, D Vijaya ^a,b   Hotha, Kishore Kumar ^a   Sagar, P V Vidya ^a   Kumar, S Sirish ^a   Naidu, A ^b   Mullangi, Ramesh ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

^b JNTUH COLLEGE OF ENGINEERING   (India)

Author keywords

Human plasma; LC MS MS; Pharmacokinetics; Pramipexole; Validation

Indexed keywords

PHARMACOKINETICS; PHASE SEPARATION; PLASMA (HUMAN);

CLINICAL PHARMACOKINETICS; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; MEMANTINE; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; PRAMIPEXOLE; VALIDATION;

ELECTROSPRAY IONIZATION;

ACETONITRILE; AMMONIUM ACETATE; BUFFER; MEMANTINE; PRAMIPEXOLE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PH; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 65349102376     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1108     Document Type: Article

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