Defining the neuropathological background of vascular and mixed dementia and comparison with magnetic resonance imaging findings

Frontiers of Neurology and Neuroscience

Volumn 24, Issue , 2009, Pages 86-94

  Gold, Gabriel ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Hopital de Geriatrie   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ALZHEIMER DISEASE; AUTOPSY; BRAIN INFARCTION; CADASIL; COGNITION; COMPARATIVE STUDY; DEMYELINATION; GLIOSIS; HUMAN; INTELLECTUAL IMPAIRMENT; LEUKOARAIOSIS; MIXED DEPRESSION AND DEMENTIA; MULTIINFARCT DEMENTIA; NEUROFIBRILLARY TANGLE; NEUROIMAGING; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SCORING SYSTEM; WHITE MATTER; BRAIN; DEMENTIA; PATHOLOGY; RADIOGRAPHY;

ALZHEIMER DISEASE; BRAIN; DEMENTIA; DEMENTIA, VASCULAR; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 65349085749     PISSN: 16604431     EISSN: 16622804     Source Type: Book Series    
DOI: 10.1159/000197887     Document Type: Review

References (35)

1. Mast H, Tatemichi TK, Mohr JP: Chronic brain ischemia: the contributions of Otto Binswanger and Alois Alzheimer to the mechanisms of vascular dementia. J Neurol Sci 1995;132:4-10.
2. Neuropathology group of the medical research council cognitive function and ageing study (MRC CFAS): Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001;357:169-175.
3. Fernando MS, Ince PG: Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 2004;226:13-17.
4. Tomlinson BE, Blessed G, Roth M: Observations on the brains of non-demented old people. J Neurol Sci 1968;7:331-356.
5. Tomlinson BE, Blessed G, Roth M: Observations on the brains of demented old people. J Neurol Sci 1970;11:205-242.
6. Hachinski VD, Lassen NA, Marshall J: Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet 1974;2:207-210.
7. Desmond DW, Moroney JT, Sano M, Stern Y: Incidence of dementia after ischemic stroke: results of a longitudinal study. Stroke 2002;33:2254-2260.
8. Jellinger KA: Understanding the pathology of vascular cognitive impairment. J Neurol Sci 2005;229-230:57-63.
9. Esiri MM, Wilcock GK, Morris JH: Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 1997;63:749-753.
10. Kövari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel J P, Bouras C, Giannakopoulos P: Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 2004; 35:410-414.
11. Jellinger KA: The enigma of vascular cognitive disorder and vascular dementia. Acta Neuropathol 2007;113:349-388.
12. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner M W, Schuff N, Norman D, Mack WJ, Willis L, Chui HC: MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology 2001;57:2229-2235.
13. Mungas D, Reed BR, Jagust WJ, DeCarli C, Mack WJ, Kramer JH, Weiner M W, Schuff N, Chui HC: Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease. Neurology 2002;59:867-873.
14. Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Mack WJ, Kramer JH, Weiner M W, Schuff N, Chui HC: Longitudinal volumetric MRI change and rate of cognitive decline. Neurology 2005; 65:565-571.
15. Liem MK, van der Grond J, Haan J, van den Boom R, Ferrari MD, Knaap YM, Breuning MH, van Buchem MA, Middelkoop HA, Lesnik Oberstein SA: Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL. Stroke 2007;38: 923-928.
16. Jellinger KA, Attems J: Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study. Acta Neuropathol (Berl) 2003;105:14-17.
17. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR: Brain infarction and the clinical expression of Alzheimer disease. The nun study. J Am Med Assoc 1997;277:813-817.
18. Pantoni L, Sarti C, Alafuzoff I, Jellinger K, Munoz DG, Ogata J, Palumbo V: Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services. Stroke 2006; 37:1005-1009.
19. Gold G, Kövari E, Herrmann FR, Canuto A, Hof PR, Michel J P, Bouras C, Giannakopoulos P: Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 2005;36:1184-1188.
20. Chui HC: Subcortical ischemic vascular dementia. Neurol Clin 2007;25:717-740.
21. Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Jolles J, Koudstaal PJ, Hofman A, Breteler MM: Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 2005;128:2034-2041.
22. Bracco L, Piccini C, Moretti M, Mascalchi M, Sforza A, Nacmias B, Cellini E, Bagnoli S, Sorbi S: Alzheimer's disease: role of size and location of white matter changes in determining cognitive deficits. Dement Geriatr Cogn Disord 2005;20:358-366.
23. Swartz RH, Stuss DT, Gao F, Black SE: Independent cognitive effects of atrophy and diffuse subcortical and thalamico-cortical cerebrovascular disease in dementia. Stroke 2008;39:822-830.
24. Libon DJ, Price CC, Giovannetti T, Swenson R, Bettcher BM, Heilman KM, Pennisi A: Linking MRI hyperintensities with patterns of neuropsychological impairment: evidence for a threshold effect. Stroke 2008;39:806-813.
25. McMurtray AM, Liao A, Haider J, Licht E, Mendez MF: Cognitive performance after lacunar stroke correlates with leukoaraiosis severity. Cerebrovasc Dis 2007;24:271-276.
26. Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters H V, Weiner M W, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, Schuff N, DeCarli C, Chui HC: Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol 2008; 63:72-80.
27. Udaka F, Sawada H, Kameyama M: White matter lesions and dementia: MRI-pathological correlation. Ann N Y Acad Sci 2002;977:411-415.
28. Jellinger KA: Morphologic diagnosis of 'vascular dementia' - a critical update. J Neurol Sci 2008; 270: 1-12.
29. Kövari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, Giannakopoulos P: Cortical microin-farcts and demyelination affect cognition in cases at high risk for dementia. Neurology 2007;68:927-931.
30. Fein G, Di Sclafani V, Tanabe J, Cardenas V, Weiner M W, Jagust WJ, Reed BR, Norman D, Schuff N, Kusdra L, Greenfield T, Chui H: Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology 2000;55:1626-1635.
31. Du AT, Schuff N, Laakso M P, Zhu XP, Jagust WJ, Yaffe K, Kramer JH, Miller BL, Reed BR, Norman D, Chui HC, Weiner MW: Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus. Neurology 2002;58:1635-1641.
32. Bastos-Leite AJ, van der Flier WM, van Straaten EC, Staekenborg SS, Scheltens P, Barkhof F: The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia. Stroke 2007;38:3182-3185.
33. Jellinger KA, Attems J: Neuropathological evaluation of mixed dementia. J Neurol Sci 2007;257: 80-87.
34. Schneider JA, Boyle PA, Arvanitakis Z, Bienias JL, Bennett DA: Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann Neurol 2007;62:59-66.
35. Gold G, Giannakopoulos P, Herrmann FR, Bouras C, Kövari E: Identification of Alzheimer and vascular lesion thresholds for mixed dementia. Brain 2007;130:2830-2836.