Fatal adverse reaction to ketorolac tromethamine in asthmatic patient

American Journal of Forensic Medicine and Pathology

Volumn 29, Issue 4, 2008, Pages 358-363

  Campobasso, Carlo P ^a   Procacci, Rossella ^b   Caligara, Marina ^c  

^a UNIVERSITY OF MOLISE   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Adverse drug reaction; Anaphylactoid reaction; Anaphylaxis; Asthma; Ketorolac tromethamine

Indexed keywords

ACETYLSALICYLIC ACID; KETOROLAC; KETOROLAC TROMETAMOL; LIXIDOL; NONSTEROID ANTIINFLAMMATORY AGENT; SALMETEROL XINAFOATE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTHMA; AWARENESS; BLOOD; BRONCHOSPASM; CADAVER; CASE REPORT; DEATH; DRUG FATALITY; FEMALE; HUMAN; PAIN; PHYSICIAN; WRIST; CHEMICALLY INDUCED DISORDER; HEART ARREST; INTRAMUSCULAR DRUG ADMINISTRATION; MASS FRAGMENTOGRAPHY; MIDDLE AGED;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BRONCHIAL SPASM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEART ARREST; HUMANS; INJECTIONS, INTRAMUSCULAR; KETOROLAC TROMETHAMINE; MIDDLE AGED;

EID: 65249190324     PISSN: 01957910     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAF.0b013e318185a00a     Document Type: Article

References (53)

1. Chesanow N, Fleming H. Physicians' Desk Reference. 2005. Toradol (ketorolac tromethamine). 59th ed. Montvale, NJ: Thompson PDR; 2005:2932.
2. Fiedler MA. Clinical implications of ketorolac for postoperative analgesia. J Perianesth Nurs. 1997;12:426-433.
3. Estes LL, Fuhs DW, Heaton AH, et al. Gastric ulcer perforation associated with the use of injectable ketorolac. Ann Pharmacother. 1993;27:42-43.
4. Famularo G, Bizzarri C, Nicotra GC. Acute pancreatitis caused by ketorolac tromethamine. J Clin Gastroenterol. 2002;34:283-284.
5. RuDusky BM. Severe postoperative hemorrhage attributed to singledose parenteral ketorolac-induced coagulopathy. Angiology. 2000;51: 999-1002.
6. Corelli RL, Gericke KR. Renal insufficiency associated with intramuscular administration of ketorolac tromethamine. Ann Pharmacother. 1993;27:1055-1057.
7. Szczeklik A. Adverse reactions to aspirin and non-steroidal anti-inflammatory drugs. Ann Allergy. 1987;59:113-118.
8. Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology, et al. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol. 2005;115:S483-S523.
9. Weiner M, Bernstein IL. Adverse Reactions to Drug Formulation Agents, a Handbook of Excipients. New York, NY: Marcel Dekker Inc; 1989:20 -22.
10. Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology, et al. Executive summary of disease management of drug hypersensitivity: a practice parameter. Ann Allergy Asthma Immunol. 1999;83:S665-S700.
11. Szczeklik A, Gryglewski RJ. Asthma and anti-inflammatory drugs. Mechanisms and clinical patterns. Drugs. 1983;25:533-543.
12. Szczeklik A. Analgesics, allergy and asthma. Drugs. 1986;32:148 -163.
13. Sturtevant J. NSAID-induced bronchospasm-a common and serious problem. A report from MEDSAFE, the New Zealand Medicines and Medical Devices Safety Authority. N Z Dent J. 1999;95:84.
14. Szczeklik A, Stevenson DD. Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. J Allergy Clin Immunol. 2003;111:913-921.
15. Hamad AM, Sutcliffe AM, Knox AJ. Aspirin-induced asthma: clinical aspects, pathogenesis and management. Drugs. 2004;64:2417-2432.
16. Chen AH, Bennet CR. Ketorolac-induced bronchospasm in an aspirinintolerant patient. Anesth Prog. 1994;41:102-107.
17. Sitenga GL, Ing EB, Van Dellen RG, et al. Asthma caused by topical application of ketorolac. Ophtalmology. 1996;103:890-892.
18. Goetz CM, Sterchele JA, Harchelroad FP. Anaphylactoid reaction following ketorolac tromethamine. Ann Pharmacother. 1992;26:1237-1238.
19. Jung D, Mroszezak E, Bynum L. Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration. Eur J Clin Pharmacol. 1988;35:423-425.
20. Logan BK, Friel PN, Peterson KL, et al. Analysis of ketorolac in postmortem blood. J Anal Toxicol. 1995;19:61-64.
21. Wang Z, Dsida RM, Avram MJ. Determination of ketorolac in human plasma by reversed-phase high-performance liquid chromatography using solid-phase extraction and ultraviolet detection. J Chromatogr B Biomed Sci Appl. 2001;755:383-386.
22. Wu AT, Massey IJ. Simultaneous determination of ketorolac and its hydroxylated metabolite in plasma by high-performance liquid chromatography. J Chromatogr. 1990;534:241-246.
23. Jones DJ, Bjorksten AR. Detection of ketorolac enantiomers in human plasma using enantioselective liquid chromatography. J Chromatogr B Biomed Appl. 1994;661:165-167.
24. Flores-Murrieta FJ, Granados-Soto V, Hong E. Determination of ketorolac in blood and plasma samples by high-performance liquid chromatography. Boll Chim Farm. 1994;133:588 -591.
25. Chaudhary RS, Gangwal SS, Jindal KC, et al. Reversed-phase high-performance liquid chromatography of ketorolac and its application to bioequivalence studies in human serum. J Chromatogr. 1993;614:180-184.
26. Pumphrey RS, Roberts IS. Postmortem findings after fatal anaphylactic reactions. J Clin Pathol. 2000;53:273-276.
27. Yunginger JW, Nelson DR, Squillace DL, et al. Laboratory investigation of deaths due to anaphylaxis. J Forensic Sci. 1991;36:857-865.
28. Randall D, Butts J, Halsey J. Elevated post-mortem tryptase in the absence of anaphylaxis. J Forensic Sci. 1995;40:208 -211.
29. Edston E, van Hag-Hamsten M. Beta-tryptase measurements postmortem in anaphylactic deaths and in controls. Forensic Sci Int. 1998; 93:135-142.
30. Edston E, Gidlund E, Wickman M, et al. Increased mast cell tryptase in sudden infant death syndrome: anaphylaxis, hypoxia, or artifact? Clin Exp Allergy. 1999;29:648-654.
31. Schwartz LB, Yunginger JW, Miller J, et al. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest. 1989;83:1551-1555.
32. Slepian IK, Mathews KP, McLean JA. Aspirin-sensitive asthma. Chest. 1985;87:386 -391.
33. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G, et al. Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different mycrosomal enzymatic preparations. J Allergy Clin Immunol. 1976;58:10-18.
34. Morrow JD, Roberts LJ. Lipid-derived autacoids. Eicosanoids and platelet-activating factor. In: Hardman JD, Limbird LE, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: Mc Graw-Hill; 2001:669-686.
35. Roberts LJ, Morrow JD. Analgesic-antypiretic and anti-inflammatory agents. In: Hardman JD, Limbird LE, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: Mc Graw-Hill; 2001:687-732.
36. Smith LJ. Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents. Arch Intern Med. 1996;156:2181-2189.
37. Bisgaard H. Role of leuokotrienes in asthma pathophysiology. Pedriatr Pulmonol. 2000;30:166 -176.
38. Krawiec ME, Wenzel SE. Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma. Expert Opin Pharmacother. 2001; 2:47-65.
39. Smith LJ. Comparative efficacy of inhaled corticosteroids and antileukotriene drugs in asthma. BioDrugs. 2001;15:239 -249.
40. Takahama H, Kubota Y, Mizoguchi M. A case of anaphylaxis due to ibuprofen. J Dermatol. 2000;27:337-340.
41. Egede F. A fatal asthmatic reaction following ketoprofen (Alreumat), (Orudis). Ugeskr Laeger. 1979;141:1151-1152 [in Danish].
42. Ross JE. Naproxen-induced anaphylaxis. A case report. Am J Forensic Med Pathol. 1994;15:180 -181.
43. Alkhawajah AM, Eifawal M, Mahmoud SF. Fatal anaphylactic reaction to diclofenac. Forensic Sci Int. 1993;60:107-110.
44. Bokan-Erdeljan H, Martinovic J, Davidovic S, et al. An anaphylactic reaction after administration of Novagetol in asthmatic patient. Srp Arh Celok Lek. 1991;119:41-42 [Serbian].
45. Szczeklik A, Czerniawska-Mysik G, Nizankowska E. Sulphinpyrazone and aspirin-induced asthma. N Engl J Med. 1980;303:702-703.
46. Jett GK, Wilson E. Anaphylactic reaction associated with sulindac. Ann Emerg Med. 1984;13:462-464.
47. Levy DB, Vasilomanolakis EC. Anaphylactic reaction due to zomepirac. Drug Intell Clin Pharmacol. 1984;18:983-984.
48. Rossi AC, Knapp DE. Tolmetin-induced anaphylactoid reactions. N Engl J Med. 1982;307:499 -500.
49. Poe TE, Limpert GH, Winker GJ. Anaphylactoid reaction to diflunisal. J Fam Pract. 1989;28:104 -105.
50. Morild I, Giertsen JC. Sudden death from asthma. Forensic Sci Int. 1989;42:145-150.
51. Di Maio VJ, Di Maio D. Forensic Pathology. 2nd ed. Boca Raton, FL: CRC Press; 2001:76 -77.
52. Meeker DP, Wiedeman HP. Drug-induced bronchospasm. Clin Chest Med. 1990;11:163-175.
53. National Association of Medical Examiners. A guide for manner of death classification. Available at: http://www.TheNAME.org. Accessed July 24, 2007.