Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: A comparative study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 14-15, 2009, Pages 1530-1536

  Xu, Lina ^a   Liu, Yuetao ^a   Wang, Tie ^b   Qi, Yan ^a   Han, Xu ^a   Xu, Youwei ^a   Peng, Jinyong ^a   Tang, Xinqiang ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Qingzhou People's Hospital   (China)

Author keywords

Diosgenin; Hyperlipidemic rat; LC MS MS; Pharmacokinetics; Sarsasapogenin

Indexed keywords

CLINICAL USE; COMPARATIVE STUDIES; DIOSGENIN; ETHYL ACETATES; HYPERLIPIDEMIC RAT; INTER-ASSAY VARIABILITIES; INTERNAL STANDARDS; LC-ESI-MS/MS; LC-MS/MS; LIMIT OF QUANTIFICATIONS; LINEAR CALIBRATION CURVES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIES; MULTIPLE-REACTION MONITORING MODES; N HEXANES; NON-AQUEOUS; ORAL ADMINISTRATIONS; SARSASAPOGENIN;

CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; ESTERS; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMAS;

RATS;

ACETIC ACID ETHYL ESTER; DIOSGENIN; N HEXANE ETHYL ACETATE; SARSASAPOGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ELECTROSPRAY MASS SPECTROMETRY; HYPERLIPIDEMIA; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REACTION ANALYSIS; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DIOSGENIN; HUMANS; HYPERLIPIDEMIAS; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 65249183887     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.03.039     Document Type: Article

References (23)

1. Ibrahim W., Lee U.S., Yeh C.C., Szabo J., Bruckner G., and Chow C.K. J. Nutr. 127 (1997) 1401
2. Huang Q.L., Jin Y., Zhang L.N., Cheung P.C.K., and Kennedy J.F. Carbohydr. Polym. 70 (2007) 324
3. Mullan B.A., Ennis C.N., Fee H.J.P., Young I.S., and McCance D.R. Am. J. Physiol. Heart C 287 (2004) H1262
4. Bowen P.E., and Borthakur G. Curr. Atheroscler. Rep. 6 (2004) 477
5. Bainton D., Miller N.E., Botton C.H., Yarnell J.W.G., Suretman P.M., Baker I.A., Lewis B., and Elwood P.C. Br. Heart J. 68 (1992) 60
6. Wilson P.W.F. Am. J. Cardiol. 66 (1990) 7A
7. Cerdon C., Brenac P., and Sauvaire Y. Biochem. System Ecol. 23 (1995) 211
8. Tang S.R., Yang R.T., Pan F.S., Zhao A.M., and Pang Z.J. J. Plant Resour. Environ. 16 (2007) 64
9. Yang R.T., Tang S.R., Pan F.S., Zhao A.M., and Pang Z.J. Chin. Wild Plant Resour. 26 (2007) 1
10. Chen H., Wang C., and Chang C.T. Nutrition 19 (2003) 646
11. Kamisako T., and Ogawa H. Hepatol. Res. 26 (2003) 348
12. Uchida K., Takase H., Nomura Y., Takeda K., Takeuchi N., and Ishikawa Y. J. Lipid Res. 25 (1984) 236
13. Cayen M.N., and Dvornik D. J. Lipid Res. 20 (1979) 162
14. Cayen M.N., and Dvornik D. Atherosclerosis 29 (1978) 317
15. Ma H.Y., Zhao Z.T., Wang L.J., Wang Y., Zhou Q.L., and Wang B.X. Chin. J. Chin. Mater. Med. 27 (2002) 825
16. Son I.S., Kim J.H., and Sohn H.Y. Biosci. Biotechnol. Biochem. 71 (2007) 3063
17. Nappez C., Liagre B., and Beneytout J.L. Cancer Lett. 96 (1995) 133
18. Sandra M., Bertrand L., Cécile C., Arnaud B., Michel D., Karim B., and Jean L.B. FEBS Lett. 506 (2001) 225
19. Higdon K., Scott A., Tucci M., Benghyzzi H., Tsao A., Puckett A., Cason Z., and Hughes J. Biomed. Sci. Instrum. 37 (2001) 281
20. Liu L.J., Liu Y.Q., Chang Y.R., Li Q.J., and Wang B.X. Chin. J. Pharm. Anal. 26 (2006) 177
21. Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER), 2001 Center for Veterinary Medicine (CV), 2001, http://www/fda.gov/cder/guidance/index.htm.
22. G.Z. Han, Parmacokonetics of Chinese Traditional and Herbal Drugs. (2009), Beijing.
23. Wen J., Wu Y.W., Zhang L.L., Qi Y.P., Fan G.R., Wu Y.T., and Li Z. J. Chromatogr. B 867 (2008) 153