Clinical utility of measuring T-cell immunity to CMV in transplant recipients

American Journal of Transplantation

Volumn 9, Issue 5, 2009, Pages 987-988

  Danziger Isakov, L ^a   Heeger, P S ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EDITORIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT RECIPIENT; HLA SYSTEM; HUMAN; IMMUNOLOGICAL MONITORING; PRIORITY JOURNAL; PROTEIN INDUCTION; QUANTITATIVE ASSAY; RISK ASSESSMENT; SEROLOGY;

CYTOMEGALOVIRUS INFECTIONS; HUMANS; IMMUNITY, CELLULAR; RISK FACTORS; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY;

EID: 65249168783     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02599.x     Document Type: Editorial

References (7)

1. Cytomegalovirus. Am J Transplant 2004 4 (Suppl 10 51 58.
2. Singh N. Cytomegalovirus infection in solid organ transplant recipients: New challenges and their implications for preventive strategies. J Clin Virol 2006 35 : 474 477.
3. Cummins NW, Deziel PJ, Abraham RS, Razonable RR. Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with late-onset CMV disease several years after transplantation. Transpl Infect Dis 2009 11 : 20 27.
4. Bunde T, Kirchner A, Hoffmeister B et al. Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J Exp Med 2005 201 : 1031 1036.
5. Westall GP, Mifsud NA, Kotsimbos T. Linking CMV serostatus to episodes of CMV reactivation following lung transplantation by measuring CMV-specific CD8+ T-cell immunity. Am J Transplant 2008 8 : 1749 1754.
6. Walker S, Fazou C, Crough T et al. Ex vivo monitoring of human cytomegalovirus-specific CD8+ T-cell responses using QuantiFERON-CMV. Transpl Infect Dis 2007 9 : 165 170.
7. Kumar D, Chernenko S, Moussa G et al. Cell-mediated Immunity to predict Cytomegalovirus disease in high-risk solid organ transplant recipients. Am J Transplant 2009 (in press).