Highly sensitive method for the determination of omeprazole in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 23, Issue 4, 2009, Pages 390-396

  Vittal, Shivva ^a   Ganneboina, Ramesh ^a   Layek, Buddhadev ^a   Trivedi, Ravi Kumar ^a   Hotha, Kishore Kumar ^a   Bharathi, D Vijaya ^a   Mullangi, Ramesh ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Human plasma; LC MS MS; Method validation; Omeprazole; Pharmacokinetics

Indexed keywords

ACETONITRILE; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; PLASMA (HUMAN); POSITIVE IONS;

ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; METHOD VALIDATIONS; OMEPRAZOLE; PHARMACOKINETIC STUDIES; SENSITIVE METHOD;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM ACETATE; LANSOPRAZOLE; OMEPRAZOLE;

ACCURACY; ALKALINIZATION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HUMAN; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

EID: 65249159149     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1129     Document Type: Article

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