Negative smad expression and regulation in the developing chick limb

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Vargesson, Neil ^a,c   Laufer, Ed ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD7A PROTEIN; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; INHIBITION KINETICS; LIMB DEVELOPMENT; MESENCHYME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; LIMB; MOLECULAR GENETICS; PHYLOGENY; PRENATAL DEVELOPMENT;

AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; CLONING, MOLECULAR; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; SMAD6 PROTEIN; SMAD7 PROTEIN;

EID: 65249158521     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005173     Document Type: Article

References (37)

1. Amthor H, Christ B, Rashid-Doubell F, Kemp CF, Lang E, et al. (2002) Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth. Dev Biol 243: 115-127.
2. Capdevila J, Johnson RL (1998) Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev Biol 197: 205-217.
3. Dahn RD, Fallon JF (2000) Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling. Science 289: 438-441.
4. Hogan B (1996) Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes & Dev 10: 1580-1594.
5. Montero JA, Lorda-Diez CI, Ganan Y, Macias D, Hurle J (2008) Activin/ TGFbeta and BMP crosstalk determines digit chrondrogenesis. Dev Biol 321: 343-356.
6. Pizette S, Niswander L (2000) BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev Biol 219: 237-249.
7. Pizette S, Abate-Shen C, Niswander L (2001) BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128: 4463-4474.
8. Robert B (2007) Bone morphogenetic protein signalling in limb outgrowth and patterning. Dev Growth Differ 49: 455-468.
9. Suzuki T, Hasso SM, Fallon JF (2008) Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity. Proc Natl Acad Sci USA 105: 4185-4190.
10. Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, et al. (2006) BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 38: 1424-1429.
11. Yokouchi Y, Sakiyama J, Kameda T, Iba H, Suzuki A, et al. (1996) BMP-2/ -4 mediate programmed cell death in chicken limb buds. Development 122: 3725-3734.
12. Zou H, Niswander L (1996) Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272: 738-741.
13. Massague J (1998) TGF-beta signal transduction. Annu Rev Biochem 67: 753-791.
14. Massague J, Chen YG (2000) Controlling TGF-beta signaling. Genes Dev 14: 627-644.
15. Miyazono K, ten Dijke P, Heldin CH (2000) TGF-beta signaling by Smad proteins. Adv Immunol 75: 115-157.
16. Park SH (2005) Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J Biochem Mol Biol 38: 9-16.
17. Mowbray C, Hammerschmidt M, Whitfield TT (2001) Expression of BMP signaling pathway members in the developing zebrafish inner ear and lateral line. Mech Dev 108: 179-184.
18. Yamada M, Szendro PI, Prokscha A, Schwartz RJ, Eichele G (1999) Evidence for a role of Smad6 in chick cardiac development. Dev Biol 215: 48-61.
19. Zuzarte-Luis V, Montero JA, Rodriguez-Leon J, Merino R, Rodriguez-Rey JC, et al. (2004) A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol 272: 39-52.
20. Francis PH, Richardson MK, Brickell PM, Tickle C (1994) Bone morphogenetic proteins and a signaling pathway that controls patterning in the developing chick limb. Development 120: 209-218.
21. Capdevila J, Tsukui T, Rodriquez Esteban C, Zappavigna V, Izpisua Belmonte JC (1999) Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol Cell 4: 839-849.
22. Khokha MK, Hse D, Brunet LJ, Dionne MS, Harland RM (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genetics 34: 303-307.
23. Merino R, Rodriguez-Leon J, Macias D, Ganan Y, Economides AN, et al. (1999) The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126: 5515-5522.
24. Verheyden JM, Sun X (2008) An Fgf/gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature 454: 638-641.
25. Zuniga A, Haramis AP, McMahon AP, Zeller R (1999) Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401: 598-602.
26. Zou H, Wieser R, Massague J, Niswander L (1997) Distinct roles of type1 bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes & Dev 11: 2191-2203.
27. Hamburger H, Hamilton HL (1951) A series of normal stages in the development of the chick embryo. J Exp Morphol 88: 49-92.
28. Nieto MA, Sargent MG, Wilkinson DG, Cooke J (1994) Control of cell behavior during vertebrate development by Slug, a zinc finger protein. Science 264: 835-839.
29. Nieto MA, Patel K, Wilkinson DG (1996) In situ hybridization analysis of chick embryos in whole mount and tissue sections. Methods Cell Biol 51: 219-235.
30. Mackem S, Mahon KA (1991) Ghox4.7:a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression. Development 112: 791-806.
31. Nakayama T, Snyder MA, Grewal SS, Tsuneizumi K, Tabata T, et al. (1998) Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Development 125: 857-867.
32. Topper JN, Cai J, Qiu Y, Anderson KR, Xu YY, et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci USA 94: 9314-9319.
33. Benson DA, Boguski MS, Lipman DJ, Ostell J, Ouellette BF (1998) GenBank. Nucleic Acids Res 26: 1-7.
34. Laufer E, Dahn R, Orozco OE, Yeo CY, Pisenti J, et al. (1997) Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation [published erratum appears in Nature 1997 Jul 24;388(6640):400]. Nature 386: 366-373.
35. Vargesson N, Laufer E (2001) Smad7 misexpression during embryonic angiogenesis causes vascular dilation and malformations independently of vascular smooth muscle cell function. Dev Biol 240: 499-516.
36. Logan M, Tabin C (1998) Targeted gene misexpression in chick limb buds using avian replication-competent retroviruses. Methods 14: 407-420.
37. Riddle RD, Johnson RL, Laufer E, Tabin C (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401-1416.