High glucose concentration leads to differential expression of tight junction proteins in human retinal pigment epithelial cells

Endocrinologia y Nutricion

Volumn 56, Issue 2, 2009, Pages 53-58

  Villarroel, Marta ^a   García Ramírez, Marta ^a,b   Corraliza, Lidia ^a,b   Hernández, Cristina ^a,b   Simó, Rafael ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Blood retinal barrier; Cell culture; Retinal pigment epithelium; Tight junction

Indexed keywords

CLAUDIN 1; GLUCOSE; MEMBRANE PROTEIN; OCCLUDIN; UNCLASSIFIED DRUG; ZONULA OCCLUDENS 1;

ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TIGHT JUNCTION; UPREGULATION; WESTERN BLOTTING;

BLOOD-RETINAL BARRIER; CELL LINE, TRANSFORMED; DIABETIC RETINOPATHY; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE PROTEINS; GLUCOSE; HUMANS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; TIGHT JUNCTIONS; UP-REGULATION;

EID: 65249154129     PISSN: 15750922     EISSN: 15792021     Source Type: Journal    
DOI: 10.1016/S1575-0922(09)70552-2     Document Type: Article

References (17)

1. Congdon N.G., Friedman D.S., and Lietman T. Important causes of visual impairment in the world today. JAMA 290 (2003) 2057-2060
2. Lightman S., and Towler H.M. Diabetic retinopathy. Clin Cornerstone 5 (2003) 12-21
3. Joussen A., Smyth N., and Niessen C. Pathophysiology of diabetic macular edema. Dev Ophthalmol 39 (2007) 1-12
4. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 85 (2005) 845-881
5. Erickson K.K., Sundstrom J.M., and Antonetti D.A. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis 10 (2007) 103-117
6. Gonzalez-Mariscal L., Betanzos A., Nava P., and Jaramillo B.E. Tight junction proteins. Progr Biophy Mol Biol 81 (2003) 1-44
7. Chang C.W., Ye L., Defoe D.M., and Caldwell R.B. Serum inhibits tight junction formation in cultured pigment epithelial cells. Invest Ophthalmol Vis Sci 38 (1997) 1082-1093
8. Zech J.C., Pouverau I., Cotinet A., Goureau O., Le Varlet B., and DeKozak Y. Effect of cytokines and nitric oxide on tight junctions in cultured rat retinal pigment epithelium. Invest Ophthalmol Vis Sci 39 (1998) 1600-1608
9. Jin M., Barron E., He S., Ryan S.J., and Hinton D.R. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci 43 (2002) 2782-2790
10. Abe T., Sugano E., Saigo Y., and Tamai M. Interleukin-1β and barrier function of retinal pigment epithelial cells (ARPE-19): aberrant expression of junctional complex molecules. Invest Ophthalmol Vis Sci 44 (2003) 4097-4104
11. Miyamoto N., De Kozak Y., Jeanny J.C., Glotin A., Mascarelli F., Massin P., et al. Placental growth factor-1 and epithelial haematoretinal barrier breakdown: potential implications in the pathogenesis of diabetic retinopathy. Diabetologia 50 (2007) 461-470
12. King G.L., and Suzuma K. Pigment-epithelium-derived factor: a key coordinator of retinal neuronal and vascular functions. N Engl J Med 342 (2000) 349-351
13. Peng S., Rahner C., and Rizzolo L.J. Apical and basal regulation of the permeability of the retinal pigment epithelium. Invest Ophthalmol Vis Sci 44 (2003) 808-817
14. Ghassemifar R., Lai C.M., and Rakoczy P.E. VEGF differentially regulates transcription and translation of ZO-1alpha+ and ZO-1alpha- and mediates trans-epithelial resistance in cultured endothelial and epithelial cells. Cell Tissue Res 323 (2006) 117-125
15. Turksen K., and Troy T.C. Barriers built on claudins. J Cell Sci 117 Pt 12 (2004) 2435-2447
16. Busik J.V., Mohr S., and Grant M.B. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes 57 (2008) 1952-1965
17. Luo Y., Zhuo Y., Fukuhara M., and Rizzolo L.J. Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line. Invest Ophthalmol Vis Sci 47 (2006) 3644-3655