Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.

Drug metabolism letters

Volumn 1, Issue 1, 2007, Pages 7-11

  Katta, Anand ^a   Dhananjeyan, Mugunthu ^a   Bykowski, Crystal ^a   Erhardt, Paul ^a   Hacker, Miles ^a   White, Donald B ^a   Bachmann, Kenneth ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESLORATADINE; DRUG DERIVATIVE; GLYCOPROTEIN P; HISTAMINE H1 RECEPTOR ANTAGONIST; LORATADINE; PROBENECID; VERAPAMIL;

ANIMAL; ARTICLE; ATAXIA; BRAIN; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG INTERACTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLISM; MOUSE; TISSUE DISTRIBUTION;

ANIMALS; ATAXIA; BRAIN; CHROMATOGRAPHY, LIQUID; DRUG INTERACTIONS; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; LORATADINE; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; P-GLYCOPROTEIN; PROBENECID; TISSUE DISTRIBUTION; VERAPAMIL;

EID: 65249145162     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231207779814391     Document Type: Article

References (0)