Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression

Journal of Bacteriology

Volumn 191, Issue 8, 2009, Pages 2795-2805

  Donegan, Niles P ^a   Cheung, Ambrose L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; SIGMA FACTOR B; SMAD ANCHOR FOR RECEPTOR ACTIVATION; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL TOXIN; MAZE PROTEIN, STAPHYLOCOCCUS AUREUS; SARA PROTEIN, STAPHYLOCOCCUS AUREUS; SIGB PROTEIN, BACTERIA; SIGMA FACTOR; TRANSCRIPTION FACTOR;

ARTICLE; BACTERIAL GENE; DOWN REGULATION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; MAZEF GENE; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; STRESS; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENE ORDER; METABOLISM; PHYSIOLOGY; PROMOTER REGION;

STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; BACTERIAL TOXINS; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENE ORDER; GENES, BACTERIAL; OPERON; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGMA FACTOR; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION FACTORS;

EID: 65249145128     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01713-08     Document Type: Article

References (48)

1. Aizenman, E., H. Engelberg-Kulka, and G. Glaser. 1996. An Escherichia coli chromosomal "addiction module" regulated by guanosine 3',5'-bispyrophos- phate: a model for programmed bacterial cell death. Proc. Natl. Acad. Sci. USA 93:6059-6063.
2. Arnaud, M., A. Chastanet, and M. Debarbouille. 2004. New vector for efficient allelic replacement in naturally non-transformable, low-GC-content, gram-positive bacteria. Appl. Environ. Microbiol. 70:6887-6891.
3. Bae, T., A. K. Banger, A. Wallace, E. M. Glass, F. Aslund, O. Schneewind, and D. M. Missiakas. 2004. Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc. Natl. Acad. Sci. USA 101:12312-12317.
4. Bayer, M. G., J. H. Heinrichs, and A. L. Cheung. 1996. The molecular architecture of the sar locus in Staphylococcus aureus. J. Bacteriol. 178:4563-4570.
5. B regulon. J. Bacteriol. 186:4085-4099.
6. Budde, P. P., B. M. Davis, J. Yuan, and M. K. Waldor. 2007. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J. Bacteriol. 189:491-500.
7. A-RNA polymerase-dependent promoters. J. Mol. Biol. 286:683-693.
8. Cheung, A.L., K. J. Eberhardt, and V. A. Fischetti. 1994. Amethodtoisolate RNA from gram-positive bacteria and mycobacteria. Anal. Biochem. 222: 511-514.
9. Cheung, A. L., and A. C. Manna. 2005. Role of the distal sarA promoters in SarA expression in Staphylococcus aureus. Infect. Immun. 73:4391-4394.
10. Cheung, A. L., C. C. Nast, and A. S. Bayer. 1998. Selective activation of sar promoters with the use of green fluorescent protein transcriptional fusions as the detection system in the rabbit endocarditis model. Infect. Immun. 66: 5988-5993.
11. Cheung, A. L., K. A. Nishina, M. P. Trotonda, and S. Tamber. 2008. The SarA protein family of Staphylococcus aureus. Int. J. Biochem. Cell Biol. 40:355-361.
12. Chien, Y.-t., A. C. Manna, S. J. Projan, and A. L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol. Chem. 274:37169-37176.
13. Christensen, S. K., M. Mikkelsen, K. Pedersen, and K. Gerdes. 2001. RelE, a global inhibitor of translation, is activated during nutritional stress. Proc. Natl. Acad. Sci. USA 98:14328-14333.
14. de Hoon, M. J., Y. Makita, K. Nakai, and S. Miyano. 2005. Prediction of transcriptional terminators in Bacillus subtilis and related species. PLoS Comput. Biol. 1:e25.
15. Dunman, P. M., E. Murphy, S. Haney, D. Palacios, G. Tucker-Kellogg, S. Wu, E. L. Brown, R. J. Zagursky, D. Shlaes, and S. J. Projan. 2001. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J. Bacteriol. 183:7341-7353.
16. Duthie, E. S., and L. L. Lorenz. 1952. Staphylococcal coagulase; mode of action and antigenicity. J. Gen. Microbiol. 6:95-107.
17. sa, an endoribonuclease from Staphylococcus aureus. J. Bacteriol. 189:8871-8879.
18. Gerdes, K., S. K. Christensen, and A. Lobner-Olesen. 2005. Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol. 3:371-382.
19. B-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains. Mol. Gen. Genet. 261:558-566.
20. Gotfredsen, M., and K. Gerdes. 1998. The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol. Microbiol. 29:1065-1076.
21. Grady, R., and F. Hayes. 2003. Axe-Txe, a broad-spectrum proteic toxin- antitoxin system specified by a multidrug-resistant, clinical isolate of Entero- coccus faecium. Mol. Microbiol. 47:1419-1432.
22. B-dependent general stress response in Bacillus subtilis and related gram-positive bacteria. Annu. Rev. Microbiol. 61:215-236.
23. A-dependent promoter sequences: evidence for extended contact between RNA polymerase and upstream promoter DNA. Nucleic Acids Res. 23:2351-2360.
24. Igoshin, O. A., M. S. Brody, C. W. Price, and M. A. Savageau. 2007. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. J. Mol. Biol. 369:1333-1352.
25. B-dependent mechanism. J. Bacteriol. 187:8181-8184.
26. King, M. D., B. J. Humphrey, Y. F. Wang, E. V. Kourbatova, S. M. Ray, and H. M. Blumberg. 2006. Emergence of community-acquired methicillin-resis- tant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann. Intern. Med. 144:309-317.
27. Kluytmans, J., A. van Belkum, and H. Verbrugh. 1997. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev. 10:505-520.
28. Kreiswirth, B. N., S. Lofdahl, M. J. Betley, M. O'Reilly, P. M. Schlievert, M. S. Bergdoll, and R. P. Novick. 1983. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305:709-712.
29. Kullik, I., R. Jenni, and B. Berger-Bachi. 1998. Sequence of the putative alanine racemase operon in Staphylococcus aureus: insertional interruption of this operon reduces D-alanine substitution of lipoteichoic acid and autol- ysis. Gene 219:9-17.
30. Liu, G. Y., A. Essex, J. T. Buchanan, V. Datta, H. M. Hoffman, J. F. Bastian, J. Fierer, and V. Nizet. 2005. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J. Exp. Med. 202:209-215.
31. Liu, Y., A. C. Manna, C.-H. Pan, I. A. Kriksunov, D. J. Thiel, A. L. Cheung, and G. Zhang. 2006. Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 103: 2392-2397.
32. Maeda, H., N. Fujita, and A. Ishihama. 2000. Competition among seven Escherichia Colia subunits: relative binding affinities to the core RNA poly-merase. Nucleic Acids Res. 28:3497-3503.
33. Magnuson, R. D. 2007. Hypothetical functions of toxin-antitoxin systems. J. Bacteriol. 189:6089-6092.
34. Meehl, M., S. Herbert, F. Gotz, and A. Cheung. 2007. Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 51:2679-2689.
35. B-depen- dent arlRS and yabJ-spoVG loci affect capsule formation in Staphylococcus aureus. Infect. Immun. 75:4562-4571.
36. B by rsbU-dependent and -independent mechanisms. J. Bacteriol. 188:5896-5903.
37. B Activity in Staphylococcus aureus is controlled by RsbU and an additional factor(s) during bacterial growth. Infect. Immun. 69:7858-7865.
38. Pandey, D. P., and K. Gerdes. 2005. Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res. 33:966-976.
39. Rechtin, T. M., A. F. Gillaspy, M. A. Schumacher, R. G. Brennan, M. S. Smeltzer, and B. K. Hurlburt. 1999. Characterization of the SarA virulence gene regulator of Staphylococcus aureus. Mol. Microbiol. 33:307-316.
40. B to core RNA polymerase after environmental stress in Bacillus subtilis. J. Bacteriol. 185:35-40.
41. Sat, B., R. Hazan, T. Fisher, H. Khaner, G. Glaser, and H. Engelberg-Kulka. 2001. Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. J. Bacteriol. 183:2041-2045.
42. Schenk, S., and R. A. Laddaga. 1992. Improved method for electroporation of Staphylococcus aureus. FEMS Microbiol. Lett. 73:133-138.
43. B operon in Staphylococcus aureus.J. Bacteriol. 187:8006-8019.
44. Shafer, W. M., and J. J. Iandolo. 1979. Genetics of staphylococcal entero- toxin B in methicillin-resistant isolates of Staphylococcus aureus. Infect. Im-mun. 25:902-911.
45. Solberg, C. O. 2000. Spread of Staphylococcusaureusinhospitals: causes and prevention. Scand. J. Infect. Dis. 32:587-595.
46. Taylor, M. D., and L. M. Napolitano. 2004. Methicillin-resistant Staphylo- coccus aureus infections in vascular surgery: increasing prevalence. Surg. Infect. 5:180-187.
47. B and its role in acid tolerance and virulence of Listeria monocytogenes. J. Bacteriol. 180:3650-3656.
48. Zhang, J., Y. Zhang, and M. Inouye. 2003. Characterization of the interactions within the mazEF addiction module of Escherichia coli. J. Biol. Chem. 278:32300-32306.