Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3443-3455

  Cressina, Elena ^a   Lloyd, Adrian J ^b   De Pascale, Gianfranco ^a,b   James Mok, B ^c   Caddick, Stephen ^c   Roper, David I ^b   Dowson, Christopher G ^b   Bugg, Timothy D H ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antibacterial; FemABX; Inhibition; Ligase; MurMN; Peptidoglycan biosynthesis; Streptococcus pneumoniae

Indexed keywords

2' (1 AMINOETHYLPHOSPHONYL)ADENOSINE; 2' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL]ADENOSINE; 3' (1 AMINOETHYLPHOSPHONYL) 2' DEOXYADENOSINE; 3' (1 AMINOETHYLPHOSPHONYL)ADENOSINE; 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYL PHOSPHONYL]ADENOSINE; 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL] 2' DEOXYADENOSINE; 3' METHYLPHOSPHONYL 2' DEOXYADENOSINE; 5' (METHYLCARBAMOYL) 2' DEOXYADENOSINE; 5' (TERT BUTYLDIMETHYLSILYL) 2' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL]ADENOSINE; 5' (TERT BUTYLDIMETHYLSILYL) 3' (1 AMINOETHYLPHOSPHONYL) 2' DEOXYADENOSINE; 5' (TERT BUTYLDIMETHYLSILYL) 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL] 2' DEOXYADENOSINE; 5' (TERT BUTYLDIMETHYLSILYL) 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL]ADENOSINE; ENZYME INHIBITOR; LIGASE; N6 BENZOYL 5' (TERT BUTYLDIMETHYLSILYL) 2' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL]ADENOSINE; N6 BENZOYL 5' (TERT BUTYLDIMETHYLSILYL) 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL] 2' DEOXYADENOSINE; N6 BENZOYL 5' (TERT BUTYLDIMETHYLSILYL) 3' [1 (BENZYLOXYCARBONYLAMINO)ETHYLPHOSPHONYL]ADENOSINE; PHOSPHONIC ACID INHIBITOR; PROTEIN MURM; SULFONAMIDE INHIBITOR; TRANSFER RNA; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ADENINE NUCLEOTIDES; BACTERIAL PROTEINS; CATALYSIS; HUMANS; MODELS, MOLECULAR; PEPTIDE SYNTHASES; PHOSPHONIC ACIDS; RNA LIGASE (ATP); STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 65249142845     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.028     Document Type: Article

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