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Volumn 15, Issue 5, 2009, Pages 947-957

Differential functions of two editosome exoUases in trypanosoma brucei

Author keywords

Endonuclease; Exonuclease; KRE; KREX2; Phosphatase domain; Rna editing; Trypanosoma brucei

Indexed keywords

EXONUCLEASE; MESSENGER RNA; MULTIPROTEIN COMPLEX; NUCLEOTIDE DERIVATIVE; PROTEIN EDITOSOME EXOUASE DERIVATIVE; PROTEIN KREN1; PROTEIN KREN2; RNA; UNCLASSIFIED DRUG; URIDINE;

EID: 65249140056     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1373009     Document Type: Article
Times cited : (29)

References (48)
  • 1
    • 0037040412 scopus 로고    scopus 로고
    • Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): The key enzyme in U-insertion/deletion RNA editing
    • Aphasizhev, R., Sbicego, S., Peris, M., Jang, S.H., Aphasizheva, I., Simpson, A.M., Rivlin, A., and Simpson, L. 2002. Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): The key enzyme in U-insertion/deletion RNA editing. Cell 108: 637-648.
    • (2002) Cell , vol.108 , pp. 637-648
    • Aphasizhev, R.1    Sbicego, S.2    Peris, M.3    Jang, S.H.4    Aphasizheva, I.5    Simpson, A.M.6    Rivlin, A.7    Simpson, L.8
  • 4
    • 34247340565 scopus 로고    scopus 로고
    • An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei
    • Babbarwal, V.K., Fleck, M., Ernst, N.L., Schnaufer, A., and Stuart, K.D. 2007. An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei. RNA 2007: 737-744.
    • (2007) RNA , vol.2007 , pp. 737-744
    • Babbarwal, V.K.1    Fleck, M.2    Ernst, N.L.3    Schnaufer, A.4    Stuart, K.D.5
  • 5
    • 14644397311 scopus 로고    scopus 로고
    • TbMP42, a protein component of the RNA editing complex in African trypanosomes has endo-exoribonuclease activity
    • Brecht, M., Niemann, M., Schluter, E., Muller, U.F., Stuart, K., and Goringer, H.U. 2005. TbMP42, a protein component of the RNA editing complex in African trypanosomes has endo-exoribonuclease activity. Mol. Cell 17: 621-630.
    • (2005) Mol. Cell , vol.17 , pp. 621-630
    • Brecht, M.1    Niemann, M.2    Schluter, E.3    Muller, U.F.4    Stuart, K.5    Goringer, H.U.6
  • 6
    • 28044439400 scopus 로고    scopus 로고
    • An essential RNase III insertion editing endonuclease in Trypanosoma brucei
    • Carnes, J., Trotter, J.R., Ernst, N.L., Steinberg, A.G., and Stuart, K. 2005. An essential RNase III insertion editing endonuclease in Trypanosoma brucei. Proc. Natl. Acad. Sci. 102: 16614-16619.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 16614-16619
    • Carnes, J.1    Trotter, J.R.2    Ernst, N.L.3    Steinberg, A.G.4    Stuart, K.5
  • 7
    • 37549054714 scopus 로고    scopus 로고
    • RNA editing in Trypanosoma brucei requires three different editosomes
    • Carnes, J., Trotter, J.R., Peltan, A., Fleck, M., and Stuart, K. 2008. RNA editing in Trypanosoma brucei requires three different editosomes. Mol. Cell. Biol. 28: 122-130.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 122-130
    • Carnes, J.1    Trotter, J.R.2    Peltan, A.3    Fleck, M.4    Stuart, K.5
  • 8
    • 0034213216 scopus 로고    scopus 로고
    • 2+-dependent endonucleases
    • 2+-dependent endonucleases. Trends Biochem. Sci. 25: 272-273.
    • (2000) Trends Biochem. Sci , vol.25 , pp. 272-273
    • Dlakic, M.1
  • 10
    • 0038433297 scopus 로고    scopus 로고
    • TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome
    • Ernst, N.L., Panicucci, B., Igo Jr., R.P., Panigrahi, A.K., Salavati, R., and Stuart, K. 2003. TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome. Mol. Cell 11: 1525-1536.
    • (2003) Mol. Cell , vol.11 , pp. 1525-1536
    • Ernst, N.L.1    Panicucci, B.2    Igo Jr., R.P.3    Panigrahi, A.K.4    Salavati, R.5    Stuart, K.6
  • 11
    • 0042346420 scopus 로고    scopus 로고
    • Is the Trypanosoma brucei REL1 RNA ligase specific for U-deletion RNA editing, and is the REL2 RNA ligase specific for U-insertion editing?
    • Gao, G. and Simpson, L. 2003. Is the Trypanosoma brucei REL1 RNA ligase specific for U-deletion RNA editing, and is the REL2 RNA ligase specific for U-insertion editing? J. Biol. Chem. 278: 27570-27574.
    • (2003) J. Biol. Chem , vol.278 , pp. 27570-27574
    • Gao, G.1    Simpson, L.2
  • 12
    • 55849153500 scopus 로고    scopus 로고
    • The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei
    • Guo, X., Ernst, N.L., and Stuart, K.D. 2008. The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei. Mol. Cell. Biol. 28: 6939-6953.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 6939-6953
    • Guo, X.1    Ernst, N.L.2    Stuart, K.D.3
  • 13
    • 0026780427 scopus 로고
    • Specific cleavage of pre-edited mRNAs in trypanosome mitochon- drial extracts
    • Harris, M., Decker, C., Sollner-Webb, B., and Hajduk, S. 1992. Specific cleavage of pre-edited mRNAs in trypanosome mitochon- drial extracts. Mol. Cell. Biol. 12: 2591-2598.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 2591-2598
    • Harris, M.1    Decker, C.2    Sollner-Webb, B.3    Hajduk, S.4
  • 14
    • 0036235406 scopus 로고    scopus 로고
    • Assembly and function of the RNA editing complex in Trypanosoma brucei requires band III protein
    • Huang, C.E., O'Hearn, S.F., and Sollner-Webb, B. 2002. Assembly and function of the RNA editing complex in Trypanosoma brucei requires band III protein. Mol. Cell. Biol. 22: 3194-3203.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 3194-3203
    • Huang, C.E.1    O'Hearn, S.F.2    Sollner-Webb, B.3
  • 16
    • 0034953244 scopus 로고    scopus 로고
    • Quantitative real-time PCR assay for determining transgene copy number in transformed plants
    • Ingham, D.J., Beer, S., Money, S., and Hansen, G. 2001. Quantitative real-time PCR assay for determining transgene copy number in transformed plants. Biotechniques 31: 132-140.
    • (2001) Biotechniques , vol.31 , pp. 132-140
    • Ingham, D.J.1    Beer, S.2    Money, S.3    Hansen, G.4
  • 17
    • 0029788229 scopus 로고    scopus 로고
    • RNA editing: A mechanism for gRNA-specified uridylate insertion into precursor mRNA
    • Kable, M.L., Seiwert, S.D., Heidmann, S., and Stuart, K. 1996. RNA editing: A mechanism for gRNA-specified uridylate insertion into precursor mRNA. Science 273: 1189-1195.
    • (1996) Science , vol.273 , pp. 1189-1195
    • Kable, M.L.1    Seiwert, S.D.2    Heidmann, S.3    Stuart, K.4
  • 18
    • 1042278183 scopus 로고    scopus 로고
    • Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex
    • Kang, X., Falick, A.M., Nelson, R.E., Gao, G., Rogers, K., Aphasizhev, R., and Simpson, L. 2004. Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex. J. Biol. Chem. 279: 3893-3899.
    • (2004) J. Biol. Chem , vol.279 , pp. 3893-3899
    • Kang, X.1    Falick, A.M.2    Nelson, R.E.3    Gao, G.4    Rogers, K.5    Aphasizhev, R.6    Simpson, L.7
  • 19
    • 12844285613 scopus 로고    scopus 로고
    • Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes
    • Kang, X., Rogers, K., Gao, G., Falick, A.M., Zhou, S., and Simpson, L. 2005. Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes. Proc. Natl. Acad. Sci. 102: 1017-1022.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 1017-1022
    • Kang, X.1    Rogers, K.2    Gao, G.3    Falick, A.M.4    Zhou, S.5    Simpson, L.6
  • 20
    • 33749023006 scopus 로고    scopus 로고
    • Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins
    • Kang, X., Gao, G., Rogers, K., Falick, A.M., Zhou, S., and Simpson, L. 2006. Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins. Proc. Natl. Acad. Sci. 103: 13944-13949.
    • (2006) Proc. Natl. Acad. Sci , vol.103 , pp. 13944-13949
    • Kang, X.1    Gao, G.2    Rogers, K.3    Falick, A.M.4    Zhou, S.5    Simpson, L.6
  • 21
    • 15044358727 scopus 로고    scopus 로고
    • In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle
    • Law, J.A., Huang, C.E., O'Hearn, S.F., and Sollner-Webb, B. 2005. In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. Mol. Cell. Biol. 25: 2785-2794.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 2785-2794
    • Law, J.A.1    Huang, C.E.2    O'Hearn, S.F.3    Sollner-Webb, B.4
  • 22
    • 0035014563 scopus 로고    scopus 로고
    • RNA editing-associated protein 1 is an RNA binding protein with specificity for preedited mRNA
    • Madison-Antenucci, S. and Hajduk, S. 2001. RNA editing-associated protein 1 is an RNA binding protein with specificity for preedited mRNA. Mol. Cell 7: 879-886.
    • (2001) Mol. Cell , vol.7 , pp. 879-886
    • Madison-Antenucci, S.1    Hajduk, S.2
  • 23
    • 0037154955 scopus 로고    scopus 로고
    • Editing machines: The complexities of trypanosome RNA editing
    • Madison-Antenucci, S., Grams, J., and Hajduk, S.L. 2002. Editing machines: The complexities of trypanosome RNA editing. Cell 108: 435-438.
    • (2002) Cell , vol.108 , pp. 435-438
    • Madison-Antenucci, S.1    Grams, J.2    Hajduk, S.L.3
  • 24
    • 0035260718 scopus 로고    scopus 로고
    • Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei
    • McManus, M.T., Shimamura, M., Grams, J., and Hajduk, S.L. 2001. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA 7: 167-175.
    • (2001) RNA , vol.7 , pp. 167-175
    • McManus, M.T.1    Shimamura, M.2    Grams, J.3    Hajduk, S.L.4
  • 26
    • 0028923440 scopus 로고
    • Structure and function of the multifunctional DNA-repair enzyme exonuclease III
    • Mol, C.D., Kuo, C.F., Thayer, M.M., Cunningham, R.P., and Tainer, J.A. 1995. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature 374: 381-386.
    • (1995) Nature , vol.374 , pp. 381-386
    • Mol, C.D.1    Kuo, C.F.2    Thayer, M.M.3    Cunningham, R.P.4    Tainer, J.A.5
  • 27
    • 0142091443 scopus 로고    scopus 로고
    • Trypanosoma brucei RNA editing complex: Band II is structurally critical and maintains band V ligase, which is nonessential
    • O'Hearn, S., Huang, C.E., Hemann, M., Zhelonkina, A., and Sollner- Webb, B. 2003. Trypanosoma brucei RNA editing complex: Band II is structurally critical and maintains band V ligase, which is nonessential. Mol. Cell. Biol. 23: 7909-7919.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7909-7919
    • O'Hearn, S.1    Huang, C.E.2    Hemann, M.3    Zhelonkina, A.4    Sollner- Webb, B.5
  • 31
    • 33646870148 scopus 로고    scopus 로고
    • Compositionally and functionally distinct editosomes in Trypanosoma brucei
    • Panigrahi, A.K., Ernst, N.L., Domingo, G.J., Fleck, M., Salavati, R., and Stuart, K.D. 2006. Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA 12: 1038-1049.
    • (2006) RNA , vol.12 , pp. 1038-1049
    • Panigrahi, A.K.1    Ernst, N.L.2    Domingo, G.J.3    Fleck, M.4    Salavati, R.5    Stuart, K.D.6
  • 32
    • 35748960520 scopus 로고    scopus 로고
    • Uridylate-specific 3'-5' exoribonucleases involved in uridylate-deletion RNA editing in Trypanosomatid mitochondria
    • Rogers, K., Gao, G., and Simpson, L. 2007. Uridylate-specific 3'-5' exoribonucleases involved in uridylate-deletion RNA editing in Trypanosomatid mitochondria. J. Biol. Chem. 282: 29073-29080.
    • (2007) J. Biol. Chem , vol.282 , pp. 29073-29080
    • Rogers, K.1    Gao, G.2    Simpson, L.3
  • 33
    • 0030928201 scopus 로고    scopus 로고
    • Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria
    • Rusche, L.N., Cruz-Reyes, J., Piller, K.J., and Sollner-Webb, B. 1997. Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. EMBO J. 16: 4069-4081.
    • (1997) EMBO J , vol.16 , pp. 4069-4081
    • Rusche, L.N.1    Cruz-Reyes, J.2    Piller, K.J.3    Sollner-Webb, B.4
  • 34
    • 0035145703 scopus 로고    scopus 로고
    • The two RNA ligases of the Trypanosoma brucei RNA editing complex: Cloning the essential Band IV gene and identifying the Band V gene
    • Rusché, L.N., Huang, C.E., Piller, K.J., Hemann, M., Wirtz, E., and Sollner-Webb, B. 2001. The two RNA ligases of the Trypanosoma brucei RNA editing complex: Cloning the essential Band IV gene and identifying the Band V gene. Mol. Cell. Biol. 21: 979-989.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 979-989
    • Rusché, L.N.1    Huang, C.E.2    Piller, K.J.3    Hemann, M.4    Wirtz, E.5    Sollner-Webb, B.6
  • 35
    • 33646189413 scopus 로고    scopus 로고
    • KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei
    • Salavati, R., Ernst, N.L., O'Rear, J., Gilliam, T., Tarun Jr., S., and Stuart, K. 2006. KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA 12: 819-831.
    • (2006) RNA , vol.12 , pp. 819-831
    • Salavati, R.1    Ernst, N.L.2    O'Rear, J.3    Gilliam, T.4    Tarun Jr., S.5    Stuart, K.6
  • 36
    • 0035896357 scopus 로고    scopus 로고
    • An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei
    • Schnaufer, A., Panigrahi, A.K., Panicucci, B., Igo Jr., R.P., Salavati, R., and Stuart, K. 2001. An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science 291: 2159-2162.
    • (2001) Science , vol.291 , pp. 2159-2162
    • Schnaufer, A.1    Panigrahi, A.K.2    Panicucci, B.3    Igo Jr., R.P.4    Salavati, R.5    Stuart, K.6
  • 37
    • 0141922994 scopus 로고    scopus 로고
    • Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex
    • Schnaufer, A., Ernst, N., O'Rear, J., Salavati, R., and Stuart, K. 2003. Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol. Cell 12: 307-319.
    • (2003) Mol. Cell , vol.12 , pp. 307-319
    • Schnaufer, A.1    Ernst, N.2    O'Rear, J.3    Salavati, R.4    Stuart, K.5
  • 38
    • 0029942430 scopus 로고    scopus 로고
    • Direct visualization of uridylate deletion in vitro suggests a mechanism for kineto- plastid RNA editing
    • Seiwert, S.D., Heidmann, S., and Stuart, K. 1996. Direct visualization of uridylate deletion in vitro suggests a mechanism for kineto- plastid RNA editing. Cell 84: 831-841.
    • (1996) Cell , vol.84 , pp. 831-841
    • Seiwert, S.D.1    Heidmann, S.2    Stuart, K.3
  • 39
    • 0037371743 scopus 로고    scopus 로고
    • Uridine insertion/ deletion RNA editing in trypanosome mitochondria: A complex business
    • Simpson, L., Sbicego, S., and Aphasizhev, R. 2003. Uridine insertion/ deletion RNA editing in trypanosome mitochondria: A complex business. RNA 9: 265-276.
    • (2003) RNA , vol.9 , pp. 265-276
    • Simpson, L.1    Sbicego, S.2    Aphasizhev, R.3
  • 40
    • 1642580825 scopus 로고    scopus 로고
    • Mitochon- drial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing
    • Simpson, L., Aphasizhev, R., Gao, G., and Kang, X. 2004. Mitochon- drial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing. RNA 10: 159-170.
    • (2004) RNA , vol.10 , pp. 159-170
    • Simpson, L.1    Aphasizhev, R.2    Gao, G.3    Kang, X.4
  • 43
    • 38649125860 scopus 로고    scopus 로고
    • KREPA6 is an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei
    • Tarun Jr., S.Z., Schnaufer, A., Ernst, N.L., Proff, R., Deng, J., Hol, W., and Stuart, K. 2008. KREPA6 is an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA 14: 347-358.
    • (2008) RNA , vol.14 , pp. 347-358
    • Tarun Jr., S.Z.1    Schnaufer, A.2    Ernst, N.L.3    Proff, R.4    Deng, J.5    Hol, W.6    Stuart, K.7
  • 44
  • 45
    • 0034704084 scopus 로고    scopus 로고
    • Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters
    • Wang, Z., Morris, J.C., Drew, M.E., and Englund, P.T. 2000. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J. Biol. Chem. 275: 40174-40179.
    • (2000) J. Biol. Chem , vol.275 , pp. 40174-40179
    • Wang, Z.1    Morris, J.C.2    Drew, M.E.3    Englund, P.T.4
  • 46
    • 0037805672 scopus 로고    scopus 로고
    • TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei
    • Wang, B., Ernst, N.L., Palazzo, S.S., Panigrahi, A.K., Salavati, R., and Stuart, K. 2003. TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei. Eukaryot. Cell 2: 578-587.
    • (2003) Eukaryot. Cell , vol.2 , pp. 578-587
    • Wang, B.1    Ernst, N.L.2    Palazzo, S.S.3    Panigrahi, A.K.4    Salavati, R.5    Stuart, K.6
  • 47
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for conditional gene knockouts and dominant-negative genetics in Trypanosoma brucei
    • Wirtz, E., Leal, S., Ochatt, C., and Cross, G.A.M. 1999. A tightly regulated inducible expression system for conditional gene knockouts and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol. 99: 89-101.
    • (1999) Mol. Biochem. Parasitol , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.M.4


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