Germ line MLH1 and MSH2 mutations in Taiwanese Lynch syndrome families: Characterization of a founder genomic mutation in the MLH1 gene

Clinical Genetics

Volumn 75, Issue 4, 2009, Pages 334-345

  Tang, R ^a   Hsiung, C ^b   Wang, J Y ^a   Lai, C H ^c   Chien, H T ^c   Chiu, L L ^c   Liu, C T ^c   Chen, H H ^a   Wang, H M ^d   Chen, S X ^e   Hsieh, Ling Ling ^c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e Kuang Tien Hospital   (Taiwan)

Author keywords

Founder mutation; Lynch syndrome; MLH1; MSH2; Mutation large deletion

Indexed keywords

ADENOSINE; CYTOSINE; GUANOSINE; PROTEIN MLH1; PROTEIN MSH2; THYMIDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EXON; FAMILIAL CANCER; FREQUENCY ANALYSIS; GENE DELETION; GENE INSERTION; GENOMICS; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INHERITANCE; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; TAIWAN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; FEMALE; FOUNDER EFFECT; GENE FREQUENCY; GERM-LINE MUTATION; HUMANS; MALE; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PEDIGREE; POINT MUTATION; SEQUENCE DELETION; TAIWAN;

EID: 65249127356     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2009.01162.x     Document Type: Article

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