Selection criteria and generalizability within the counterfactual framework: Explaining the paradox of antidepressant-induced suicidality?

Clinical Trials

Volumn 6, Issue 2, 2009, Pages 109-118

  Weisberg, Herbert I ^a,b   Hayden, Vanessa C ^a   Pontes, Victor P ^a  

^a Correlation Research Inc ^*  (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; MONOAMINE OXIDASE INHIBITOR; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

ARTICLE; ARTIFACT; CAUSAL ATTRIBUTION; CLINICAL RESEARCH; CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; DRUG SAFETY; EXTERNAL VALIDITY; FOOD AND DRUG ADMINISTRATION; HIGH RISK PATIENT; HUMAN; INCIDENCE; PATIENT SELECTION; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; STATISTICAL MODEL; SUICIDAL BEHAVIOR; SYSTEMATIC ERROR;

ADOLESCENT; ANTIDEPRESSIVE AGENTS; CHILD; CHILD, PRESCHOOL; DECISION SUPPORT TECHNIQUES; DEPRESSIVE DISORDER; HUMANS; META-ANALYSIS AS TOPIC; MODELS, THEORETICAL; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; RISK; SELECTION BIAS; SUICIDE; TREATMENT OUTCOME;

EID: 65249123486     PISSN: 17407745     EISSN: 17407753     Source Type: Journal    
DOI: 10.1177/1740774509102563     Document Type: Article

References (26)

1. Last JM A Dictionary of Epidemiology (4th edn). Oxford University Press, Oxford, 2001.
2. Greenland S., Robins J. Identifiability, exchangeability, and epidemiological confounding. Int J Epidemiol 1986; 15(3): 413-19.
3. Greenland S., Robins J., Pearl J. Confounding and collapsibility in causal inference. Stat Sci 1999; 14(1): 29-46.
4. Little RJ, Rubin DB Causal effects in clinical and epidemiological studies via potential outcomes: Concepts and analytical approaches. Ann Rev Pub Health 2000; 21: 121-145.
5. Rubin DB Estimating causal effects of treatments in randomized and nonrandomized studies. J Educ Psychol 1974; 66: 688-701.
6. Rubin DB Assignment to treatment group on the basis of a covariate. J Educ Stat 1977; 2: 1-26. Printer's erratum 1978; 3: 384.
7. Rubin DB Bayesian inference for causal effects: The role of randomization. Ann Stat 1978; 7: 34-58.
8. Rothman K., Greenland S. Modern Epidemiology (2nd edn). Lippincott, Williams & Wilkins, Boston, 1998.
9. Ellenberg J. Selection bias in observational and experimental studies. Stat Med 1994; 13(5-7): 557-67.
10. Maldonado G., Greenland S. Estimating causal effects. Int J Epidemiol 2002; 31: 422-29.
11. Rosenbaum PR, Rubin DB The central role of the propensity score in observational studies for causal effects. Biometrika 1983; 70: 41-55.
12. US Food and Drug Administration. Relationship between psychotropic drugs and pediatric suicidality. Memo on the review and evaluation of clinical data by TA Hammad, (http://www.fda.gov/ohrms/dockets/ac/briefing/ 2004-4065b1-10-TAB08-Hammads-Review.pdf) accessed 29/1/2008.
13. Hammad TA, Laughren T., Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry 2006; 63: 332-39.
14. Dubicka B., Hadley S., Roberts C. Suicidal behavior in youths with depression treated with new generation antidepressants. Brit J Psychiatry 2006; 189: 393-98.
15. Wallace AE, Neily J., Weeks WB, Friedman MJ A cumulative meta-analysis of selective seratonin reuptake inhibitors in pediatric depression: Did unpublished studies influence the efficacy/safety debate? J Child Adolesc Psychopharmacol 2006; 16(1-2): 37-58.
16. Whittington CJ, Kendall T., Fonagy P. et al. Selective serotonin reuptake inhibitors in childhood depression: Systematic review of published versus unpublished data. Lancet 2004; 363(9418): 1341-45.
17. Teicher M., Glod CA, Cole JO Antidepressant drugs and the emergence of suicidal tendencies. Drug Safety 1993; 8(3): 186-212.
18. Licinio J., Wong ML Depression, antidepressants and suicidality: A critical appraisal. Nature Reviews Drug Discovery 2005; 4: 165-71.
19. Sakinofsky I. Treating suicidality in depressive illness, part 2: Does treatment cure or cause suicidality? Can J Psychiatry 2007; 52(6, suppl 1): 85S-102S.
20. Greenhouse JB, Kaizar EE, Kelleher K. et al. Generalizing from clinical trial data: A case study. The risk of suicidality among pediatric antidepressant users. Statistics in Medicine 2008; 27(11): 1801-13.
21. Gibbons RD, Brown CH, Hur K. et al. Early evidence on the effects of regulators' suicide warnings on SSRI prescriptions and suicide in adolescents. Am J Psychiatry 2007; 164: 1356-63.
22. Bridge JA, Greenhouse JB, Weldon AH et al. Suicide trends among youths aged 10 to 19 years in the United States, 1996-2005. JAMA 2008; 300(9): 1025-26.
23. Katz LY, Kozyrskyj AL, Prior HJ et al. Effect of regulatory warnings on antidepressant prescription rates: Use of health services and outcomes among children, adolescents and young adults. CMAJ 2008; 178(8): 1005-11.
24. Laje G., Paddock S., Manji H. et al. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry 2007; 164: 1530-38.
25. Meltzer H., Harrington R., Goodman R., Jenkins R. Children and adolescents who try to harm, hurt or kill themselves: A report of further analysis from the national survey of the mental health of children and adolescents in Great Britain in 1999. Office for National Statistics, London, 2001.
26. Dubicka B., Goodyer I. Should we prescribe antidepressants to children? Psych Bull 2005; 29: 164-67.