Toxoplasma-induced autophagy: A window into nutritional futile cycles in mammalian cells?

Autophagy

Volumn 5, Issue 3, 2009, Pages 404-406

  Orlofsky, Amos ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Amino acids; Autophagy; Futile cycles; mTOR; Parasites; Protein metabolism; Toxoplasma

Indexed keywords

ARTICLE; AUTOPHAGY; CELL CYCLE; CELL FUNCTION; HOST CELL; MAMMAL CELL; NONHUMAN; TOXOPLASMA GONDII; UPREGULATION;

MAMMALIA; TOXOPLASMA; TOXOPLASMA GONDII;

ANIMALS; AUTOPHAGY; HOST-PARASITE INTERACTIONS; SIGNAL TRANSDUCTION; SUBSTRATE CYCLING; TOXOPLASMA;

EID: 65249123215     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.3.7807     Document Type: Article

References (13)

1. Schmid D, Münz C. Innate and adaptive immunity through autophagy. Immunity 2007; 27:11-21.
2. Wang Y, Weiss LM, Orlofsky A. Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem 2009; 284:1694-701.
3. Martin AM, Liu T, Lynn BC, Sinai AP The Toxoplasma gondii parasitophorous vacuole membrane: Transactions across the border. J Eukaryot Microbiol 2007; 54:25-8.
4. Fox BA, Gigley JP, Bzik DJ. Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int J Parasitol 2004; 34:323-31.
5. Mazumdar J, Striepen B. Make it or take it: fatty acid metabolism of apicomplexan parasites. Eukaryot Cell 2007; 6:1727-35.
6. Gherardi A, Sarciron ME. Molecules targeting the purine salvage pathway in Apicomplexan parasites. Trends Parasitol 2007; 23:384-9.
7. Mordue DG, Hakansson S, Niesman I, Sibley LD. Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways. Exp Parasitol 1999; 92:87-99.
8. Coppens I, Dunn JD, Romano JD, Pypaert M, Zhang H, Boothroyd JC, et al. Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space. Cell 2006; 125:261-74.
9. Reeds PJ, Wahle KW, Haggarty P. Energy costs of protein and fatty acid synthesis. Proc Nutr Soc 1982; 41:155-9.
10. Ravindran S, Boothroyd JC. Secretion of proteins into host cells by Apicomplexan parasites. Traffic 2008; 9:647-56.
11. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, et al. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab 2007; 6:181-94.
12. Wang XM, Beugnet A, Murakami M, Yamanaka S, Proud CG. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Molec Cell Biol 2005; 25:2558-72.
13. 2+/CaM signaling to hVps34. Cell Metab 2008; 7:456-65.