"Obese" smooth muscle cells fail to assemble collagen fibrils

Circulation Research

Volumn 104, Issue 7, 2009, Pages 826-828

  Leitinger, Norbert ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Atherosclerosis; Extracellular matrix; Lipids; Plaque rupture; Vascular smooth muscle cells

Indexed keywords

COLLAGEN FIBRIL; COLLAGEN TYPE 1; COLLAGEN TYPE 5; FIBRONECTIN; LOW DENSITY LIPOPROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VERY LATE ACTIVATION ANTIGEN 2; VERY LOW DENSITY LIPOPROTEIN; PROTEIN TYROSINE KINASE;

ATHEROSCLEROSIS; BLOOD VESSEL WALL; CELL COUNT; CELL MEMBRANE; CELL SIZE; CELL SURFACE; EDITORIAL; ENTROPY; HEART INFARCTION; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; SMOOTH MUSCLE FIBER; STROKE; THROMBOSIS; ANIMAL; ENZYMOLOGY; FOAM CELL; GENETICS; HUMAN; METABOLISM; NOTE; OBESITY; PARTICLE SIZE; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ATHEROSCLEROSIS; COLLAGEN TYPE I; FIBRONECTINS; FOAM CELLS; HUMANS; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OBESITY; PARTICLE SIZE; PHENOTYPE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 65249121499     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.196337     Document Type: Editorial

References (17)

1. Newby AC, Zaltsman AB. Fibrous cap formation or destruction-the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation. Cardiovasc Res. 1999;41:345-360.
2. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801.
3. Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:812-819.
4. Ang AH, Tachas G, Campbell JH, Bateman JF, Campbell GR. Collagen synthesis by cultured rabbit aortic smooth-muscle cells. Alteration with phenotype. Biochem J. 1990;265:461-469.
5. Orr AW, Lee MY, Lemmon JA, Yurdagul A Jr, Gomez MF, Bortz PD, Wamhoff BR. Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 2009;29:225-231.
6. Halvorsen B, Otterdal K, Dahl TB, Skjelland M, Gullestad L, Oie E, Aukrust P. Atherosclerotic plaque stability-what determines the fate of a plaque? Prog Cardiovasc Dis. 2008;51:183-194.
7. Deleted in proof.
8. Kadler KE, Hill A, Canty-Laird EG. Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol. 2008;20:495-501.
9. Li S, Van Den DC, D'Souza SJ, Chan BM, Pickering JG. Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization. Am J Pathol. 2003;163:1045-1056.
10. Wolfbauer G, Glick JM, Minor LK, Rothblat GH. Development of the smooth muscle foam cell: Uptake of macrophage lipid inclusions. Proc Natl Acad Sci U S A. 1986;83:7760-7764.
11. Rong JX, Shapiro M, Trogan E, Fisher EA. Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading. Proc Natl Acad Sci U S A. 2003;100:13531-13536.
12. Argmann CA, Sawyez CG, Li S, Nong Z, Hegele RA, Pickering JG, Huff MW. Human smooth muscle cell subpopulations differentially accumulate cholesteryl ester when exposed to native and oxidized lipoproteins. Arterioscler Thromb Vasc Biol. 2004;24:1290-1296.
13. Frontini MJ, O'Neil C, Sawyez C, Chan BM, Huff MW, Pickering JG. Lipid Incorporation Inhibits Src-Dependent Assembly of Fibronectin and Type I Collagen by Vascular Smooth Muscle Cells. Circ Res. 2009;104:832-841.
14. Hung YC, Hong MY, Huang GS. Cholesterol loading augments oxidative stress in macrophages. FEBS Lett. 2006;580:849-861.
15. Gleissner CA, Sanders JM, Nadler J, Ley K. Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:1137-1143.
16. Chiarugi P. Src redox regulation: There is more than meets the eye. Mol Cells. 2008;26:329-337.
17. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, Ramponi G. Reactive oxygen species as essential mediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol. 2003;161:933-944.