Quantitative determination of β,β-dimethylacrylshikonin (DASK) in rat whole blood by liquid chromatography-tandemmass spectrometry with pre-column derivation and its pharmacokinetic application

Biomedical Chromatography

Volumn 23, Issue 4, 2009, Pages 365-370

  Tian, Huifang ^a,b   Sun, Dongxiao ^a   Dou, Guifang ^a   Yuan, Dan ^b   Meng, Zhiyun ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

2 mercaptoethanol (2 ME); LC MS MS; Pharmacokinetics; Pre column derivatization; , dimethylacrylshikonin (DASK)

Indexed keywords

BLOOD; COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; RATS;

2-MERCAPTOETHANOL; COLUMN DERIVATIONS; LC-MS-MS; LC.MS/MS; PRE-COLUMN DERIVATISATION; QUANTITATIVE DETERMINATIONS; RAT WHOLE BLOOD; TANDEM-MASS SPECTROMETRY; Β,Β-DIMETHYLACRYLSHIKONIN;

PHARMACOKINETICS;

1,4 NAPHTHOQUINONE DERIVATIVE; BETA1 BETA DIMETHYLACRYLASHIKONIN; CHIGLITAZAR; CYCLOHEXANE; MERCAPTOETHANOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

RATTUS;

EID: 65249097292     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1123     Document Type: Article

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