Solute transport in intervertebral disc: Experiments and finite element modeling

Annals of the New York Academy of Sciences

Volumn 1161, Issue , 2009, Pages 44-61

  Das, D B ^a   Welling, A ^b   Urban, J P G ^b   Boubriak, O A ^b  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Degeneration; Dextran molecule; Glucose; Human intervertebral disc; Lactate; Oxygen; Solute transport

Indexed keywords

COLLAGEN; DEXTRAN; GAG PROTEIN; SODIUM;

ADULT; ARTICLE; CONCENTRATION (PARAMETERS); DIFFUSION COEFFICIENT; FINITE ELEMENT ANALYSIS; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MOLECULAR SIZE; MOLECULAR WEIGHT; NONHUMAN; NUCLEUS PULPOSUS; NUTRIENT SUPPLY; SOLUTE; STEADY STATE; TRANSPORT KINETICS; VASCULARIZATION;

EID: 65249096167     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.04075.x     Document Type: Article

References (13)

1. Antoniou, J., C.N. Demers, G. Beaudoin, et al. 2004. Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn. Reson. Imaging 22: 963-972.
2. Bibby, S.R.S., D.A. Jones, R.M. Ripley & J.P.G. Urban. 2005. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 30: 487-496.
3. Bibby, S.R.S. &J.P.G. Urban. 2004. Effect of nutrient deprivation on viability of intervertebral disc cells. Eur. Spine J. 13: 695-701.
4. Boubriak, O.A.,J.PG. Urban, S. Akhtar, et al. 2000. The effect of hydration and matrix composition on solute diffusion in rabbit sclera. Exp. Eye Res. 71: 503514.
5. Boubriak, O.A.,J.PG. Urban & A.J. Bron. 2003. Differential effects of aging on transport properties of interior and posterior human sclera. Exp. Eye Res. 76: 701-713.
6. Deghani, H. Biophysics of the extracellular matrix, unknown, School of Physics, University of Exeter, 17/3/06 http://newton.ex.ac.uk/research/ biomedical/biophys/.
7. Farndale, R.W., D.J. Buttle & A.J. Barrett. 1986. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim. Biophys. Acta 883: 173-177.
8. Ferguson, S.J., K. Ito & L.P. Noite. 2004. Fluid flow and convective transport of solutes within the intervertebral disc. J. Biomech. 37: 213-221.
9. http://www.nlm.nih.gov/medlineplus/ency/ imagepages/19469.html.
10. Horner, H.A. & J.P.G. Urban. 2001. 2001 Volvo award winner in basic science studies: effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 26: 25432549.
11. Rajasekaran, S., J.N. Babu, R. Arun, et al. 2004. ISSLS Prize Winner: A study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine 29: 2654-2667.
12. Soukane, M.D., A. Shirazi-Adl &J.P.G. Urban. 2005. Analysis of non-linear coupled diffusion of oxygen and lactate in intervertebral discs. J. Biomech. Eng. 127: 1121-1126.
13. Urban, J.P.G., S. Smith & J.C.T. Fairbank. 2004. Nutrition of the intervertebral disc. Spine 29: 27002709.