Living donor kidney transplantation from relatives with mild urinary abnormalities in Alport syndrome: Long-term risk, benefit and outcome

Nephrology Dialysis Transplantation

Volumn 24, Issue 5, 2009, Pages 1626-1630

  Gross, Oliver ^a   Weber, Manfred ^b   Fries, Jochen W U ^c   Müller, Gerhard Anton ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Alport syndrome; Benign familial haematuria; Living donor transplantation; Thin glomerular basement membrane disease; Type IV collagen

Indexed keywords

ADOLESCENT; ADULT; ALPORT SYNDROME; ARTICLE; CAUSE OF DEATH; CLINICAL ARTICLE; CREATININE CLEARANCE; DISEASE SEVERITY; FEMALE; HEMATURIA; HETEROZYGOTE; HUMAN; HUMAN TISSUE; HYPERTENSION; KIDNEY TRANSPLANTATION; LIVING DONOR; MALE; MENINGITIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEINURIA; RELATIVE; RISK BENEFIT ANALYSIS; URINARY TRACT DISEASE;

ADOLESCENT; ADULT; BIOPSY; FAMILY; FEMALE; FOLLOW-UP STUDIES; HEMATURIA; HETEROZYGOTE; HUMANS; KIDNEY; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; MOTHER-CHILD RELATIONS; NEPHRITIS, HEREDITARY; RISK ASSESSMENT; RISK FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 65249087306     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn635     Document Type: Article

References (17)

1. Alport AC. Hereditary familial congenital haemorrhagic nephritis. Br Med J 1927; 1: 504-506
2. Flinter FA, Cameron JS, Chantler C et al. Genetics of classic Alport's syndrome. Lancet 1988; ii: 1005-1007
3. Horslen S, Barr ML, Christensen LL et al. Pediatric transplantation in the United States, 1996-2005. Am J Transplant 2007; 7: 1339-1358
4. Hudson BG, Tryggvason K, Sundaramoorthy M et al. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 2003; 19: 2543-2556
5. Gross O, Netzer K-O, Lambrecht R et al. Genotype phenotype study in Alport syndrome: impact on clinical and genetic counseling. Nephrol Dial Transplant 2002; 17: 1218-1227
6. Nagel M, Nagorka S, Gross O. Novel COL4A5, COL4A4 and COL4A3 mutations in Alport syndrome. Hum Mutat 2005; 26: 60-65
7. Kashtan CE. Alport syndrome and the X chromosome: implications of a diagnosis of Alport syndrome in females. Nephrol Dial Transplant 2007; 22: 1499-1505
8. Jais JP, Knebelmann B, Giatras I et al. X-linked Alport syndrome: natural history and genotype - phenotype correlations in females belonging to 195 families. J Am Soc Nephrol 2003; 14: 2603-2610
9. Kashtan CE. Renal transplantation in patients with Alport syndrome. Pediatr Transplant 2006; 10: 651-657
10. Jais JP, Knebelmann B, Giatras I et al. X-linked Alport syndrome: natural history in 195 families and genotype - phenotype correlations in males. J Am Soc Nephrol 2000; 11: 649-657
11. Gross O, Netzer K-O, Lambrecht R et al. Novel COL4A4 splice defect and in-frame deletion in a large family as a genetic link between benign familial hematuria and autosomal Alport syndrome. Nephrol Dial Transplant 2003; 18: 1122-1127
12. Charytan D, Torre A, Khurana M et al. Allograft rejection and glomerular basement membrane antibodies in Alport's syndrome. J Nephrol 2004; 17: 431-435
13. Kashtan CE. Familial hematurias: what we know and what we don't. Pediatr Nephrol 2005; 20: 1027-1035
14. Ierino FL, KanellisJ. Thin basement membrane nephropathy and renal transplantation. Semin Nephrol 2005; 25: 184-187
15. Eberhard OK, Kliem V, Offner G et al. Assessment of long-term risks for living related kidney donors by 24-h blood pressure monitoring and testing for microalbuminuria. Clin Transplant 1997; 11: 415-459
16. Thorner PS. Alport syndrome and thin basement membrane nephropa-thy. Nephron Clin Pract 2007; 106: c82-c88
17. Gross O, Beirowski B, Koepke M-L et al. Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome. Kidney Int 2003; 63: 438-446