Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity?

American Journal of Emergency Medicine

Volumn 27, Issue 4, 2009, Pages 509-510

  Gillman, P Ken ^a  

^a NONE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; CARBAMAZEPINE; CLOMIPRAMINE; CODEINE; CYCLOBENZAPRINE; CYPROHEPTADINE; FLUVOXAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; LEVODOPA; METHYLPHENIDATE; MONOAMINE OXIDASE INHIBITOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OPIATE DERIVATIVE; SEROTONIN 2 ANTAGONIST; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; SIBUTRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

CLONUS; CONFUSION; DIAPHORESIS; DRUG EFFECT; DRUG INTOXICATION; DRUG OVERDOSE; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HYPERREFLEXIA; HYPERTHERMIA; LETTER; MYDRIASIS; NEUROPHARMACOLOGY; NYSTAGMUS; OSCILLATION; PRIORITY JOURNAL; SEDATION; SEROTONIN SYNDROME; SEROTONIN TOXICITY;

AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; HUMANS; OVERDOSE; SEROTONIN SYNDROME; SEROTONIN UPTAKE INHIBITORS;

EID: 65149102323     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2009.03.001     Document Type: Letter

References (12)

1. Day LT, and Jeanmonod RK, Serotonin syndrome in a patient taking Lexapro and Flexeril: a case report. Am. J. Emerg. Med., 2008; 26(9): 1069. e1-e3.
2. Gillman P.K. A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biol Psychiatry 59 (2006) 1046-1051
3. Whyte I.M. Serotonin toxicity (syndrome). In: Dart R.C. (Ed). Medical toxicology (2004), Lippincott Williams and Wilkins, Baltimore 103-106
4. Isbister G.K., Bowe S.J., Dawson A., and Whyte I.M. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol 42 3 (2004) 277-285
5. Isbister G.K., Buckley N.A., and Whyte I.M. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust 187 6 (2007) 361-365
6. Boyer E.W., and Shannon M. The serotonin syndrome. N Engl J Med 352 11 (2005) 1112-1120
7. Dunkley E.J.C., Isbister G.K., Sibbritt D., Dawson A.H., and Whyte I.M. Hunter serotonin toxicity criteria: a simple and accurate diagnostic decision rule for serotonin toxicity. Q J Med 96 (2003) 635-642
8. Gillman P.K. Extracting value from case reports: lessons from serotonin toxicity (serotonin syndrome). Anaesthesia 61 (2006) 419-422
9. Hooper V.D., and Andrews J.O. Accuracy of noninvasive core temperature measurement in acutely ill adults: the state of the science. Biol Res Nurs 8 1 (2006) 24-34
10. Wishart D.S., Knox C., Guo A.C., Shrivastava S., Hassanali M., Stothard P., et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res 34 Database issue (2006) D668-D672
11. Spiller H.A., Winter M.L., Mann K.V., Borys D.J., Muir S., and Krenzelok E.P. Five-year multicenter retrospective review of cyclobenzaprine toxicity. J Emerg Med 13 6 (1995) 781-785
12. Honda M., Nishida T., and Ono H. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol 458 1-2 (2003) 91-99