The Weiss system for evaluating adrenocortical neoplasms: 25 years later

Human Pathology

Volumn 40, Issue 6, 2009, Pages 757-768

  Lau, Sean K ^a   Weiss, Lawrence M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Adrenal cortex; Adrenocortical adenoma; Adrenocortical carcinoma; Weiss system

Indexed keywords

ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX TUMOR; ARTICLE; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HISTOPATHOLOGY; HUMAN; PRACTICE GUIDELINE; STANDARD; TUMOR CLASSIFICATION; TUMOR DIAGNOSIS; WEISS SYSTEM;

ADRENAL CORTEX; ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL ADENOMA; ADRENOCORTICAL CARCINOMA; ADULT; BIOPSY, FINE-NEEDLE; CELL NUCLEUS; CHILD; GENES, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; MITOSIS; NECROSIS; NEOPLASM INVASIVENESS; PROGNOSIS;

EID: 65149100026     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.03.010     Document Type: Article

References (81)

1. NIH state-of-the-science statement on management of the clinically inapparent adrenal mass ("incidentaloma"). NIH Consens State Sci Statements 19 (2002) 1-25
2. Fassnacht M., Kenn W., and Allolio B. Adrenal tumors: how to establish malignancy?. J Endocrinol Invest 27 (2004) 387-399
3. Allolio B., and Fassnacht M. Clinical review: adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 91 (2006) 2027-2037
4. Icard P., Goudet P., Charpenay C., et al. Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group. World J Surg 25 (2001) 891-897
5. Weiss L.M. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8 (1984) 163-169
6. Fuhrman S.A., Lasky L.C., and Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6 (1982) 655-663
7. Weiss L.M., Medeiros L.J., and Vickery Jr. A.L. Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 13 (1989) 202-206
8. Stojadinovic A., Ghossein R.A., Hoos A., et al. Adrenocortical carcinoma: clinical, morphologic, and molecular characterization. J Clin Oncol 20 (2002) 941-950
9. Stojadinovic A., Brennan M.F., Hoos A., et al. Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Mod Pathol 16 (2003) 742-751
10. Blanes A., and Diaz-Cano S.J. Histologic criteria for adrenocortical proliferative lesions: value of mitotic figure variability. Am J Clin Pathol 127 (2007) 398-408
11. Advani A., Vaikkakara S., Gill M.S., et al. Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review. J Clin Pathol 61 (2008) 939-944
12. Evans H.L., and Vassilopoulou-Sellin R. Adrenal cortical neoplasms. A study of 56 cases. Am J Clin Pathol 105 (1996) 76-86
13. Hough A.J., Hollifield J.W., Page D.L., and Hartmann W.H. Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphologic data. Am J Clin Pathol 72 (1979) 390-399
14. van Slooten H., Schaberg A., Smeenk D., and Moolenaar A.J. Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 55 (1985) 766-773
15. Sasano H., Suzuki T., and Moriya T. Recent advances in surgical pathology of adrenal incidentaloma. Biomed Pharmacother 54 Suppl 1 (2000) 169s-174s
16. Aubert S., Wacrenier A., Leroy X., et al. Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg Pathol 26 (2002) 1612-1619
17. Lucon A.M., Pereira M.A., Mendonça B.B., Zerbini M.C., Saldanha L.B., and Arap S. Adrenocortical tumors: results of treatment and study of Weiss's score as a prognostic factor. Rev Hosp Clin Fac Med Sao Paulo 57 (2002) 251-256
18. Gicquel C., Bertagna X., Gaston V., et al. Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors. Cancer Res 61 (2001) 6762-6767
19. Tissier F., Louvel A., Grabar S., et al. Cyclin E correlates with malignancy and adverse prognosis in adrenocortical tumors. Eur J Endocrinol 150 (2004) 809-817
20. Assié G., Antoni G., Tissier F., et al. Prognostic parameters of metastatic adrenocortical carcinoma. J Clin Endocrinol Metab 92 (2007) 148-154
21. Gandour M.J., and Grizzle W.E. A small adrenocortical carcinoma with aggressive behavior. An evaluation of criteria for malignancy. Arch Pathol Lab Med 110 (1986) 1076-1079
22. Volante M., Buttigliero C., Greco E., Berruti A., and Papotti M. Pathological and molecular features of adrenocortical carcinoma: an update. J Clin Pathol. 61 (2008) 787-793
23. van't Sant H.P., Bouvy N.D., Kazemier G., et al. The prognostic value of two different histopathological scoring systems for adrenocortical carcinomas. Histopathology 51 (2007) 239-245
24. Cagle P.T., Hough A.J., Pysher T.J., et al. Comparison of adrenal cortical tumors in children and adults. Cancer 57 (1986) 2235-2237
25. Ribeiro R.C., Sandrini Neto R.S., Schell M.J., Lacerda L., Sambaio G.A., and Cat I. Adrenocortical carcinoma in children: a study of 40 cases. J Clin Oncol 8 (1990) 67-74
26. Lack E.E., Mulvihill J.J., Travis W.D., and Kozakewich H.P. Adrenal cortical neoplasms in the pediatric and adolescent age group. Clinicopathologic study of 30 cases with emphasis on epidemiological and prognostic factors. Pathol Annu 27 Pt 1 (1992) 1-53
27. Wieneke J.A., Thompson L.D., and Heffess C.S. Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol 27 (2003) 867-881
28. Dichtchekenian V., de Bragança Pereira C.A., Kuperman H., et al. Adrenocortical carcinoma: prognostic indices based on clinical and immunohistochemical markers. J Pediatr Endocrinol Metab 18 (2005) 347-353
29. Sbragia L., Oliveira-Filho A.G., Vassallo J., et al. Adrenocortical tumors in Brazilian children: immunohistochemical markers and prognostic factors. Arch Pathol Lab Med 129 (2005) 1127-1131
30. Bugg M.F., Ribeiro R.C., Roberson P.K., et al. Correlation of pathologic features with clinical outcome in pediatric adrenocortical neoplasia. A study of a Brazilian population. Brazilian Group for Treatment of Childhood Adrenocortical Tumors. Am J Clin Pathol 101 (1994) 625-629
31. Sasano H., Suzuki T., Sano T., Kameya T., Sasano N., and Nagura H. Adrenocortical oncocytoma. A true nonfunctioning adrenocortical tumor. Am J Surg Pathol 15 (1991) 949-956
32. Lin B.T., Bonsib S.M., Mierau G.W., Weiss L.M., and Medeiros L.J. Oncocytic adrenocortical neoplasms: a report of seven cases and review of the literature. Am J Surg Pathol 22 (1998) 603-614
33. Hoang M.P., Ayala A.G., and Albores-Saavedra J. Oncocytic adrenocortical carcinoma: a morphologic, immunohistochemical and ultrastructural study of four cases. Mod Pathol 15 (2002) 973-978
34. Song S.Y., Park S., Kim S.R., and Suh Y.L. Oncocytic adrenocortical carcinomas: a pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinomas. Pathol Int 54 (2004) 603-610
35. Bisceglia M., Ludovico O., Di Mattia A., et al. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 12 (2004) 231-243
36. Bisceglia M., Ben-Dor D., and Pasquinelli G. Oncocytic adrenocortical tumors. Pathol Case Rev 10 (2005) 228-242
37. Kurek R., Von Knobloch R., Feek U., Heidenreich A., and Hofmann R. Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 166 (2001) 985
38. Seo I.S., Henley J.D., and Min K.W. Peculiar cytoplasmic inclusions in oncocytic adrenal cortical tumors: an electron microscopic observation. Ultrastruct Pathol 26 (2002) 229-235
39. Thompson G.B., and Young Jr. W.F. Adrenal incidentaloma. Curr Opin Oncol 15 (2003) 84-90
40. Schteingart D.E., Doherty G.M., Gauger P.G., et al. Management of patients with adrenal cancer: recommendations of an international consensus conference. Endocr Relat Cancer 12 (2005) 667-680
41. Zornoza J., Ordonez N., Bernardino M.E., and Cohen M.A. Percutaneous biopsy of adrenal tumors. Urology 18 (1981) 412-416
42. Heaston D.K., Handel D.B., Ashton P.R., and Korobkin M. Narrow gauge needle aspiration of solid adrenal masses. AJR Am J Roentgenol 138 (1982) 1143-1148
43. Katz R.L., Patel S., Mackay B., and Zornoza J. Fine needle aspiration cytology of the adrenal gland. Acta Cytol 28 (1984) 269-282
44. Karstrup S., Torp-Pedersen S., Nolsøe C., Horn T., and Hegedüs L. Ultrasonically guided fine-needle biopsies from adrenal tumors. Scand J Urol Nephrol Suppl 137 (1991) 31-34
45. Welch T.J., Sheedy II P.F., Stephens D.H., Johnson C.M., and Swensen S.J. Percutaneous adrenal biopsy: review of a 10-year experience. Radiology 193 (1994) 341-344
46. Dusenbery D., and Dekker A. Needle biopsy of the adrenal gland: retrospective review of 54 cases. Diagn Cytopathol 14 2 (1996) 126-134
47. de Agustín P., López-Ríos F., Alberti N., and Pérez-Barrios A. Fine-needle aspiration biopsy of the adrenal glands: a ten-year experience. Diagn Cytopathol 21 (1999) 92-97
48. Fassina A.S., Borsato S., and Fedeli U. Fine needle aspiration cytology (FNAC) of adrenal masses. Cytopathology 11 (2000) 302-311
49. Sasano H., Shizawa S., and Nagura H. Adrenocortical cytopathology. Am J Clin Pathol 104 (1995) 161-166
50. Wadih G.E., Nance K.V., and Silverman J.F. Fine-needle aspiration cytology of the adrenal gland. Fifty biopsies in 48 patients. Arch Pathol Lab Med 116 (1992) 841-846
51. Saboorian M.H., Katz R.L., and Charnsangavej C. Fine needle aspiration cytology of primary and metastatic lesions of the adrenal gland. A series of 188 biopsies with radiologic correlation. Acta Cytol 39 (1995) 843-851
52. Wu H.H., Cramer H.M., Kho J., and Elsheikh T.M. Fine needle aspiration cytology of benign adrenal cortical nodules. A comparison of cytologic findings with those of primary and metastatic adrenal malignancies. Acta Cytol 42 (1998) 1352-1358
53. Sharma S., Singh R., and Verma K. Cytomorphology of adrenocortical carcinoma and comparison with renal cell carcinoma. Acta Cytol 41 (1997) 385-392
54. Ren R., Guo M., Sneige N., Moran C.A., and Gong Y. Fine-needle aspiration of adrenal cortical carcinoma: cytologic spectrum and diagnostic challenges. Am J Clin Pathol 126 (2006) 389-398
55. Saeger W., Fassnacht M., Chita R., et al. High diagnostic accuracy of adrenal core biopsy: results of the German and Austrian adrenal network multicenter trial in 220 consecutive patients. Hum Pathol 34 (2003) 180-186
56. Vargas M.P., Vargas H.I., Kleiner D.E., and Merino M.J. Adrenocortical neoplasms: role of prognostic markers MIB-1, P53, and RB. Am J Surg Pathol 21 (1997) 556-562
57. Gupta D., Shidham V., Holden J., and Layfield L. Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms. Appl Immunohistochem Mol Morphol 9 (2001) 215-221
58. Goldblum J.R., Shannon R., Kaldjian E.P., et al. Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms. Mod Pathol 6 (1993) 663-668
59. Iino K., Sasano H., Yabuki N., et al. DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas. Mod Pathol 10 (1997) 901-907
60. McNicol A.M., Struthers A.L., Nolan C.E., Hermans J., and Haak H.R. Proliferation in adrenocortical tumors: correlation with clinical outcome and p53 status. Endocr Pathol 8 (1997) 29-36
61. Wachenfeld C., Beuschlein F., Zwermann O., et al. Discerning malignancy in adrenocortical tumors: are molecular markers useful?. Eur J Endocrinol 145 (2001) 335-341
62. Terzolo M., Boccuzzi A., Bovio S., et al. Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors. Urology 57 (2001) 176-182
63. Schmitt A., Saremaslani P., Schmid S., et al. IGFII and MIB1 immunohistochemistry is helpful for the differentiation of benign from malignant adrenocortical tumours. Histopathology 49 (2006) 298-307
64. Morimoto R., Satoh F., Murakami O., et al. Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas. Endocr J 55 (2008) 49-55
65. Erickson L.A., Jin L., Sebo T.J., et al. Pathologic features and expression of insulin-like growth factor-2 in adrenocortical neoplasms. Endocr Pathol 12 (2001) 429-435
66. Volante M., Sperone P., Bollito E., et al. Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas. Mod Pathol 19 (2006) 1563-1569
67. Koch C.A., Pacak K., and Chrousos G.P. The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors. J Clin Endocrinol Metab 87 (2002) 5367-5384
68. Libé R., and Bertherat J. Molecular genetics of adrenocortical tumours, from familial to sporadic diseases. Eur J Endocrinol 153 (2005) 477-487
69. Soon P.S., McDonald K.L., Robinson B.G., and Sidhu S.B. Molecular markers and the pathogenesis of adrenocortical cancer. Oncologist 13 (2008) 548-561
70. Kjellman M., Kallioniemi O.P., Karhu R., et al. Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy. Cancer Res 56 (1996) 4219-4223
71. Dohna M., Reincke M., Mincheva A., Allolio B., Solinas-Toldo S., and Lichter P. Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications. Genes Chromosomes Cancer 28 (2000) 145-152
72. Sidhu S., Marsh D.J., Theodosopoulos G., et al. Comparative genomic hybridization analysis of adrenocortical tumors. J Clin Endocrinol Metab 87 (2002) 3467-3474
73. Gicquel C., Raffin-Sanson M.L., Gaston V., et al. Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. J Clin Endocrinol Metab 82 (1997) 2559-2565
74. Giordano T.J., Thomas D.G., Kuick R., et al. Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 162 (2003) 521-531
75. de Fraipont F., El Atifi M., Cherradi N., et al. Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic acid microarrays identifies several candidate genes as markers of malignancy. J Clin Endocrinol Metab 90 (2005) 1819-1829
76. Velázquez-Fernández D., Laurell C., Geli J., et al. Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy. Surgery 138 (2005) 1087-1094
77. Slater E.P., Diehl S.M., Langer P., et al. Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. Eur J Endocrinol 154 (2006) 587-598
78. West A.N., Neale G.A., Pounds S., et al. Gene expression profiling of childhood adrenocortical tumors. Cancer Res 67 (2007) 600-608
79. Fernandez-Ranvier G.G., Weng J., Yeh R.F., et al. Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13. World J Surg 32 (2008) 873-881
80. Fernandez-Ranvier G.G., Weng J., Yeh R.F., et al. Identification of biomarkers of adrenocortical carcinoma using genomewide gene expression profiling. Arch Surg 143 (2008) 841-846
81. de Reyniès A., Assié G., Rickman D.S., et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 27 (2009) 1108-1115