Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3045-3049

  Kemnitzer, William ^a   Sirisoma, Nilantha ^a   Nguyen, Bao ^a   Jiang, Songchun ^a   Kasibhatla, Shailaja ^a   Crogan Grundy, Candace ^a   Tseng, Ben ^a   Drewe, John ^a   Cai, Sui Xiong ^a  

^a Epicept Corporation Inc   (United States)

Author keywords

Anticancer agents; Apoptosis inducers; HTS; SAR study

Indexed keywords

AMIDE; CASPASE; N (2 METHYLPHENYL) 9 OXO 9H FLUORENE 1 CARBOXAMIDE; N [2 (1H PYRAZOL 1 YL)PHENYL] 9 OXO 9H FLUORENE 1 CARBOXAMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; COLON CANCER; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SOLUBILITY; ENZYME ACTIVATION; ENZYME INDUCTION; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORENES; HCT116 CELLS; HUMANS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65149085411     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.009     Document Type: Article

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