Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe

Biochimica et Biophysica Acta - Biomembranes

Volumn 1788, Issue 5, 2009, Pages 983-992

  Ndayizeye, Maxime ^a   Touret, Nicolas ^a   Fliegel, Larry ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cation binding; Na+ H+ exchanger; Proline; salt tolerance; Site specific mutagenesis; sod2

Indexed keywords

AMINO ACID; ASPARTIC ACID; LYSINE; MUTANT PROTEIN; PROLINE; PROLINE 146; SERINE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN SOD2; THREONINE; THREONINE 142; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; DIGESTION; GENE DELETION; GENE MUTATION; HYDROLYSIS; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SALT TOLERANCE; SCHIZOSACCHAROMYCES POMBE; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BIOPHYSICAL PHENOMENA; DNA, FUNGAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENES, FUNGAL; ION TRANSPORT; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROLINE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SPECTROPHOTOMETRY, ATOMIC; TRYPSIN;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 65049091742     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.01.001     Document Type: Article

References (37)

1. Karmazyn M., Sawyer M., and Fliegel L. The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention. Curr. Drug Targets Cardiovasc. Haematol. Disord. 5 (2005) 323-335
2. Karmazyn M. Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target. Basic Res. Cardiol. 96 (2001) 325-328
3. Ayoub I.M., Kolarova J., Yi Z., Trevedi A., Deshmukh H., Lubell D.L., Franz M.R., Maldonado F.A., and Gazmuri R.J. Sodium-hydrogen exchange inhibition during ventricular fibrillation: beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 107 (2003) 1804-1809
4. Cox Jr. C.S., Sauer H., Allen S.J., Buja L.M., and Laine G.A. Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study. J. Thorac. Cardiovasc. Surg. 123 (2002) 959-966
5. Knight D.R., Smith A.H., Flynn D.M., MacAndrew J.T., Ellery S.S., Kong J.X., Marala R.B., Wester R.T., Guzman-Perez A., Hill R.J., Magee W.P., and Tracey W.R. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J. Pharmacol. Exp. Ther. 297 (2001) 254-259
6. + exchanger. J. Mol. Cell. Cardiol. 44 (2008) 228-237
7. + exchangers. Biochem. J. 357 (2001) 1-10
8. Slepkov E.R., Rainey J.K., Sykes B.D., and Fliegel L. Structural and functional analysis of the Na(+)/H(+) exchanger. Biochem. J. 401 (2007) 623-633
9. + antiporter confers sodium and lithium tolerance in fission yeast. EMBO J. 11 (1992) 1631-1640
10. + antiport?. FEBS Lett. 424 (1998) 1-5
11. + exchanger of fission yeast. Biochemistry 36 (1998) 8282-8288
12. + antiporting. Science 317 (2007) 799-803
13. + exchanger isoform 1. Biochem. J. 379 (2004) 31-38
14. + antiporters. J. Biol. Chem. 280 (2005) 30638-30647
15. + exchanger sod2 of the fission yeast Schizosaccharomyces pombe. Can. J. Physiol. Pharmacol. 83 (2005) 565-572
16. Flegelova H., and Sychrova H. Mammalian NHE2 Na(+)/H+ exchanger mediates efflux of potassium upon heterologous expression in yeast. FEBS Lett. 579 (2005) 4733-4738
17. Dibrov P., Smith J.J., Young P., and Fliegel L. Identification and localization of the sod2 gene product in fission yeast. FEBS Lett. 405 (1997) 119-124
18. + exchanger. Eur. J. Biochem. 268 (2001) 4674-4685
19. +-ATPase disrupt folding and biogenesis. J. Biol. Chem. 273 (1998) 7344-7388
20. + antiporter and insights into mechanism of action and regulation by pH. Nature 435 (2005) 1197-1202
21. + exchanger that are important for proton translocation. Mol. Cell Biochem. 254 (2003) 117-124
22. Reithmeier R.A., and Deber C.M. Intrinsic membrane protein structure: principles and predicition. In: Yeagle P. (Ed). The Structure of Biological Membranes (1992), CRC Press, Boca Raton 337-393 1127p
23. + exchanger isoform 1. J. Biol. Chem. 275 (2000) 7942-7949
24. + exchanger 1 (NHE1): functional and clinical implications. J. Biol. Chem. 282 (2007) 37854-37863
25. + exchanger of Schizosaccharomyces pombe. Mol. Cell. Biochem. 268 (2005) 83-92
26. Barlow D.J., and Thornton J.M. Helix geometry in proteins. J. Mol. Biol. 201 (1988) 601-619
27. Eilers M., Shekar S.C., Shieh T., Smith S.O., and Fleming P.J. Internal packing of helical membrane proteins. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 5796-5801
28. Pagant S., Kung L., Dorrington M., Lee M.C., and Miller E.A. Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal. Mol. Biol. Cell. 18 (2007) 3398-3413
29. + antiporters. Mol. Membr. Biol. 23 (2006) 349-361
30. Claros M., and von Heijne G. TopPredII: an improved software for membrane protein structure predictions. Comput. Applic. Biosci. 10 (1994) 685-686
31. + antiporter. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 6896-6901
32. Higgins D.G., and Sharp P.M. CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. Gene 73 (1988) 237-244
33. + antiporter. Cell 56 (1989) 271-280
34. + exchanger: evidence that the cytoplasmic domain mediates hormonal regulation. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 6765-6769
35. + antiporter (NhaA) from Escherichia coli. FEBS Lett. 363 (1995) 264-268
36. +-antiporter gene closely related to the salt-tolerance of yeast Zygosacchromyces rouxii. Yeast 11 (1995) 829-838
37. +-antiporter of the yeast Saccharomyces cerevisiae. FEBS Lett. 387 (1996) 89-93