In vivo biodistribution of a highly attenuated recombinant vesicular stomatitis virus expressing HIV-1 Gag following intramuscular, intranasal, or intravenous inoculation

Vaccine

Volumn 27, Issue 22, 2009, Pages 2930-2939

  Erik Johnson, J ^a   Coleman, John W ^a   Kalyan, Narender K ^a   Calderon, Priscilla ^a   Wright, Kevin J ^a   Obregon, Jennifer ^a   Ogin Wilson, Eleanor ^a   Natuk, Robert J ^a   Clarke, David K ^a   Udem, Stephen A ^a   Cooper, David ^a   Michael Hendry, R ^a  

^a WYETH RESEARCH   (United States)

Author keywords

Attenuation; Biodistribution; Pathogenicity; rVSV vector; Vesicular stomatitis virus

Indexed keywords

GAG PROTEIN; PROTEIN GAG 5; RECOMBINANT VESICULAR STOMATITIS VIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS RNA; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG MEGADOSE; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VIVO STUDY; LUNG PARENCHYMA; LYMPH NODE; MORTALITY; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TURBINATE; VESICULAR STOMATITIS VIRUS; VIRUS ATTENUATION; VIRUS CULTURE; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; WEIGHT REDUCTION;

ADMINISTRATION, INTRANASAL; AIDS VACCINES; ANIMALS; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENETIC VECTORS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MICE; MICE, INBRED BALB C; PLAQUE ASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VACCINES, ATTENUATED; VESICULOVIRUS;

EID: 65049086603     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.03.006     Document Type: Article

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