23-hydroxyursolic acid causes cell growth-inhibition by inducing caspase-dependent apoptosis in human cervical squamous carcinoma heLa cells

Anticancer Research

Volumn 29, Issue 4, 2009, Pages 995-1000

  Takaya, Makiko ^a   Nomura, Masaaki ^a   Takahashi, Tatsuo ^a   Kondo, Yoko ^a   Lee, Kyung Tae ^b   Kobayashi, Shinjiro ^a  

^a HOKURIKU UNIVERSITY   (Japan)

^b Kyung Hee University   (South Korea)

Author keywords

23 hydroxyursolic acid; Apoptosis; Caspases; Growth inhibition; Pentacyclic triterpenes

Indexed keywords

23 HYDROXYURSOLIC ACID; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; PROTEIN BCL XL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CASPASES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEMALE; HELA CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 64949176074     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Newman DJ and Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477, 2007.
2. Huang J, Tang XH, Ikejima T, Sun XJ, Wang XB, Xi RG and Wu LJ: A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. Arch Pharm Res 31: 323-329, 2008.
3. Cho CW, Choi DS, Cardone MH, Kim CW, Sinskey AJ and Rha C: Glioblastoma cell death induced by asiatic acid. Cell Biol Toxicol 22: 393-408, 2006.
4. Sun HX, Zheng QF and Tu J: Induction of apoptosis in HeLa cells by 3beta-hydroxy-12-oleanen-27-oic acid from the rhizomes oiAstilbe chinensis. Bioorg Med Chem 14: 1189-1198, 2006.
5. Ovesná Z, Vachálková A, Horváthová K and Tóthová D: Pentacyclic triterpenoic acids: new chemoprotective compounds. Minireview. Neoplasma 51: 327-333, 2004.
6. Manu KA and Kuttan G: Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. Int Immunopharmacol 8: 974-981, 2008.
7. Gurfinkel DM, Chow S, Hurren R, Gronda M, Henderson C, Berube C, Hedley DW and Schimmer AD: Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid asiatic acid. Apoptosis 11: 1463-1471, 2006.
8. Bunpo P, Kataoka K, Arimochi H, Nakayama H, Kuwahara T, Vinitketkumnuen U and Ohnishi Y: Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. J Med Invest 52: 65-73,2005.
9. Park BC, Bosire KO, Lee ES, Lee YS and Kim JA: Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett 275: 81-90,2005.
10. Hsu YL, Kuo PL, Lin LT and Lin CC: Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J Pharmacol Exp Ther 313: 333-344, 2005.
11. 2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Cancer Lett 186: 83-91, 2002.
12. Shin KM, Kim RK, Azefack TL, David L, Luc SB, Choudhary MI, Park HJ, Choi JW and Lee KT: In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. Planta Med 70: 803-807, 2004.
13. Tapondjou LA, Lontsi D, Sondengam BL, Choi J, Lee KT, Jung HJ and Park HJ: In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. Arch Pharm Res 26: 143-146, 2003.
14. Cory S, Huang DC and Adams JM: The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607, 2003.
15. Kornblau SM: The role of apoptosis in the pathogenesis, prognosis, and therapy of hematologic malignancies. Leukemia 12: S41-46, 1998.
16. Melet A, Song K, Bucur O, Jagani Z, Grassian AR and Khosravi-Far R: Apoptotic pathways in tumor progression and therapy. Adv Exp Med Biol 615: 47-79, 2008.
17. Nun̈ez G, Benedict MA, Hu Y and Inohara N: Caspases: the proteases of the apoptotic pathway. Oncogene 17: 3237-3245, 1998.
18. Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH and Peter ME: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16: 2794-2804, 1997.
19. Fischer U, Stroh C and Schulze-Osthoff K: Unique and overlapping substrate specificities of caspase-8 and caspase-10. Oncogene 25: 152-159,2006.
20. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR and Martin SJ: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144: 281-292,1999.
21. Viatour P, Bentires-Alj M, Chariot A, Deregowski V, de Leval L, Merville M-P and Bours V: NF-κB2/pl00 induces Bcl-2 expression. Leukemia 17: 1349-1356, 2003.
22. Lee HH, Dadgostar H, Cheng Q, Shu J and Cheng G: NF-kB- mediated up-regulation of Bcl-x and Bfl-l/Al is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci USA 96: 9136-9141, 1999.
23. Liu X, Togo S, Al-Mugotir M, Kim H, Fang Q, Kobayashi T, Wang X, Mao L, Bitterman P and Rennard S: NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract. Respir Res 9: 66-76, 2008.