Collaborative work on evaluation of ovarian toxicity 1) Effects of 2- or 4-week repeated-dose administration and fertility studies with medroxyprogesterone acetate in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Ohtake, Sachiyo ^a   Fukui, Motoko ^a   Hisada, Shigeru ^a  

^a Grelan Pharmaceutical Co Ltd   (Japan)

Author keywords

Fertility study; Histopathology; Medroxyprogesterone acetate; Ovarian toxicity; Proliferating cell nuclear antigen; Standard toxicity study

Indexed keywords

GESTAGEN; MEDROXYPROGESTERONE ACETATE; BIOLOGICAL MARKER; CONTRACEPTIVE AGENT; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COPULATION; ESTRUS CYCLE; EVALUATION; FEMALE; FEMALE FERTILITY; HISTOPATHOLOGY; MATING; NONHUMAN; OVARY; OVARY FOLLICLE; OVARY FOLLICLE ATRESIA; PREGNANCY; RAT; REPRODUCTIVE TOXICITY; ANIMAL; ANIMAL EMBRYO; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG EFFECT; DRUG SURVEILLANCE PROGRAM; EMBRYO DEVELOPMENT; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; CONTRACEPTIVE AGENTS, FEMALE; DRUG ADMINISTRATION SCHEDULE; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILITY; JAPAN; MEDROXYPROGESTERONE 17-ACETATE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OVARY; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC;

EID: 64949149871     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s23     Document Type: Article

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