Collaborative work on evaluation of ovarian toxicity 9) Effects of 2- or 4-week repeated dose studies and fertility study of di(2-ethylhexyl)adipate (DEHA) in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Wato, Eiji ^a   Asahiyama, Masato ^a   Suzuki, Ai ^a   Funyu, Shino ^a   Amano, Yukinori ^a  

^a KOWA COMPANY LTD   (Japan)

Author keywords

DEHA; Female fertility study; Ovarian toxicity; Rats; Repeated dose toxicity study

Indexed keywords

ADIPIC ACID DERIVATIVE; BIS(2 ETHYLHEXYL)ADIPATE; UNCLASSIFIED DRUG; ADIPIC ACID DIOCTYL ESTER; PLASTICIZER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS LUTEUM; ESTRUS CYCLE; FEMALE; FEMALE FERTILITY; FOLLICLE CYST; HISTOPATHOLOGY; MATING; NONHUMAN; OVARY; OVARY FOLLICLE ATRESIA; OVULATION; PREGNANCY; RAT; REPRODUCTIVE TOXICITY; ANIMAL; ANIMAL EMBRYO; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; EMBRYO DEATH; EMBRYO DEVELOPMENT; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; MALE; METHODOLOGY; OVARY FOLLICLE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

RATTUS;

ADIPIC ACIDS; ANIMALS; DRUG ADMINISTRATION SCHEDULE; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILITY; JAPAN; MALE; OVARIAN FOLLICLE; OVARY; OVULATION; PLASTICIZERS; PREGNANCY; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; TOXICITY TESTS;

EID: 64949126958     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s101     Document Type: Article

References (8)

1. David, R.M., Moore, M.R., Finney, D.C. and Guest, D. (2000): Chronic toxicity of di(2-ethylhexyl)phthalate in rats. Toxicol. Sci., 55, 433-443.
2. Davis, B.J., Maronpot, R.R. and Heindel, J.J. (1994): Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol. Appl. Pharmacol., 128, 216-223.
3. Giuseppe, L., Egeria, S., Alberto, V., Claudio De, F. and Marika, M. (2008): Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: Epidemiological and experimental evidence. PPAR Res. 2008, Article ID 359267.
4. Holden, P.R. and Tugwood, J.D. (1999): Peroxisome proliferator activated receptor alpha: role in rodent liver cancer and species differences. J. Mol. Endocrinol., 22, 1-8.
5. Miyata, K., Shiraishi, K., Houshuyama, S., Imatanaka, N., Umano, T., Minobe, Y. and Yamasaki, K. (2006): Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch. Toxicol., 80, 181-186.
6. Motojima, K., Passilly, P., Peters, J.M., Gonzalez, F.J. and Latruffe, N. (1998): Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J. Biol. Chem., 273, 16710-16714.
7. Pedersen, T. and Peters, H. (1968): Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil., 17, 555-557.
8. Quirk, S.M., Cowan, R.G., Harman, R.M., Hu, C.L. and Porter, D.A. (2004): Ovarian follicular growth and atresia: The relationship between cell proliferation and survival. J. Anim. Sci., 82, 40-52.