Collaborative work on evaluation of ovarian toxicity 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Ishii, Shun Ichiro ^a   Ube, Masayuki ^a   Okada, Miyoko ^a   Adachi, Tamiko ^a   Sugimoto, Jiro ^a   Inoue, Yoshimi ^a   Uno, Yoshifumi ^a   Mutai, Mamoru ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Atretic follicle; Hyperprolactinemia; Ovarian toxicity; Pseudopregnancy; Rats; Sulpiride

Indexed keywords

SULPIRIDE; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIESTRUS; FEMALE; FEMALE FERTILITY; FOLLICLE CYST; HISTOLOGY; MATING; NONHUMAN; OOCYTE DEVELOPMENT; OVARY; OVARY FOLLICLE ATRESIA; PREGNANCY; RAT; REPEATED DRUG DOSE; REPRODUCTIVE TOXICITY; WEIGHT GAIN; ANIMAL; ANIMAL EMBRYO; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; EMBRYO DEVELOPMENT; ESTRUS CYCLE; FERTILITY; HEALTH CARE ORGANIZATION; HYPERPROLACTINEMIA; JAPAN; MALE; METABOLISM; METHODOLOGY; ORGAN SIZE; OVARY FOLLICLE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING; UDDER;

RATTUS;

ANIMALS; ANTIPSYCHOTIC AGENTS; BODY WEIGHT; DRUG ADMINISTRATION SCHEDULE; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILITY; FOLLICULAR CYST; HYPERPROLACTINEMIA; JAPAN; MALE; MAMMARY GLANDS, ANIMAL; ORGAN SIZE; OVARIAN FOLLICLE; OVARY; PREGNANCY; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; SULPIRIDE; TOXICITY TESTS;

EID: 64949092688     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s175     Document Type: Article

References (20)

1. Aono, T., Shioji, T., Aki, T., Hirota, K., Nomura, A. and Kurachi, K. (1979): Augmentation of puerperal lactation by oral administration of sulpiride. J. Clin. Endocrinol. Metab., 48, 478-482.
2. Caley, C.F. and Weber, S.S. (1995): Sulpiride: an antipsychotic with selective dopaminergic antagonist properties. Ann. Pharmacother., 29, 152-160.
3. Geiger, J.M., Plas-Roser, S. and Aron, C. (1980): Mechanisms of ovulation in female rats treated with FSH at the beginning of the estrous cycle: changes in pituitary responsiveness to luteinizing hormone releasing hormone (LHRH). Biol. Reprod., 22, 837-845.
4. Georg, J. Krinke (2000): The Handbook of Experimental Animals, The Laboratory Rat, pp.152-171, Academic Press, London.
5. Grosvenor, C.E. and Mena, F. (1980): Evidence that thyrotropinreleasing hormone and a hypothalamic prolactin-releasing factor may function in the release of prolactin in the lactating rat. Endocrinology, 107, 863-868.
6. Hapon, M.B., Simoncini, M., Via, G. and Jahn, G.A. (2003): Effect of hypothyroidism on hormone profiles in virgin, pregnant and lactating rats, and on lactation. Reproduction, 126, 371-382.
7. Kennedy, T.G. and Doktorcik, P.E. (1988): Uterine decidualization in hypophysectomized-ovariectomized rats: effects of pituitary hormones. Biol. Reprod., 39, 318-328.
8. Laudon, M., Grossman, D.A. and Ben-Jonathan, N. (1990): Prolactin-releasing factor: cellular origin in the intermediate lobe of the pituitary. Endocrinology, 126, 3185-3192.
9. Memo, M., Battaini, F., Spano, P.F. and Trabucchi, M. (1981): Sulpiride and the role of dopaminergic receptor blockade in the antipsychotic activity of neuroleptics. Acta Psychiatr. Scand., 63, 314-324.
10. Mielke, D.H., Gallant, D.M. and Kessler, C. (1977): An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels. Am. J. Psychiatry., 134, 1371-1375.
11. Moro, M., Inada, Y., Kojima, M, Miyata, H., Komatsu, H. and Torii, R. (1999): New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline. Eur. J. Pharmacol., 368, 57-66.
12. Muskhelishvili, L., Wingard, S.K. and Latendresse, J.R. (2005): Proliferating cell nuclear antigen -- A marker for ovarian follicle counts. Toxicol. Pathol., 33, 365-368.
13. Nahoum, C.R., Pantaleão, J.A., Freire, R.R. and Franco, S. (1984): Prolactin response to sulpiride in ovulatory women (a clue for the screening of hyperprolactinemic states). Int. J. Fertil., 29, 2024.
14. OECD (2008): OECD Test Guideline, Endocrine Disruption: A Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests, Part 3: Female Reproductive System, Draft, 3, pp.1-45.
15. Ota, H., Wakizaka, A. and Fukushima, M. (1986): Modulation of ovarian LH receptor and serum hormone levels in rats with hyperprolactinemia induced by administration of ovine prolactin or sulpiride. Tohoku. J. Exp. Med., 148, 213-227.
16. Pedersen, T. and Peters, H. (1968): Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil., 17, 555-557.
17. Rehm, S., Stanislaus, D.J. and Wier, P.J. (2007): Identification of drug-induced hyper- or hypoprolactinemia in the female rat based on general and reproductive toxicity study parameters. Birth. Defects Res. B. Dev. Reprod. Toxicol., 80, 253-257.
18. Tan, G.J. (1980): Maintenance of pseudopregnancy by prolactin in indomethacin treated rats. Clin. Exp. Pharmacol. Physiol., 7, 335-338.
19. Walker, J. and Garland, H.O. (1985): Single nephron function during prolactin-induced pseudopregnancy in the rat. J. Endocrinol., 107, 127-131.
20. Ylikorkala, O., Kauppila, A., Kivinen, S. and Viinikka, L. (1982): Sulpiride improves inadequate lactation. Br. Med. J. (Clin. Res. Ed.)., 285, 249-251.