Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites

Science

Volumn 324, Issue 5924, 2009, Pages 258-261

  Povelones, Michael ^a   Waterhouse, Robert M ^a   Kafatos, Fotis C ^a   Christophides, George K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; POLYHISTIDINE TAG; PROTEIN; PROTEIN APL1C; PROTEIN LRIM1; PROTEIN TEP1; UNCLASSIFIED DRUG;

AMINO ACID; DACITE; DEFENSE BEHAVIOR; DISEASE VECTOR; HOST-PATHOGEN INTERACTION; MALARIA; MOSQUITO; PARASITE RESISTANCE; PROTEIN; PROTOZOAN; SULFIDE;

AMINO ACID SEQUENCE; ANOPHELES GAMBIAE; ARTICLE; DISEASE TRANSMISSION; DISULFIDE BOND; EXON; GENE SEQUENCE; GENE SILENCING; HEMOLYMPH; IMMUNOPRECIPITATION; INTRON; MALARIA; MOLECULAR CLONING; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REAL TIME POLYMERASE CHAIN REACTION; SILVER STAINING; WESTERN BLOTTING;

AMINO ACID MOTIFS; ANIMALS; ANOPHELES GAMBIAE; COMPLEMENT ACTIVATION; COMPLEMENT C3; DIGESTIVE SYSTEM; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENES, INSECT; HEMOLYMPH; INSECT PROTEINS; INSECT VECTORS; LEUCINE; MULTIPROTEIN COMPLEXES; PLASMODIUM BERGHEI;

ANIMALIA; ANOPHELES GAMBIAE; PLASMODIUM BERGHEI; PLASMODIUM PARASITES;

EID: 64849109588     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1171400     Document Type: Article

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23. The authors thank A. C. Koutsos for generating the LRIM1 antibody and sharing it before publication and F. M. Ausubel for critically reviewing the manuscript. Fluorescence microscopy was performed at the Imperial College Facility for Imaging by Light Microscopy imaging facility. This work was supported by a Wellcome Trust Program grant (GR077229/Z/05/Z), an NIH Program Project (2PO1AI044220-06A1), and a Biotechnology and Biological Sciences Research Council grant (BB/E002641/1). R.M.W. was supported by a Wellcome Trust Ph.D. fellowship.