Nicotinic receptors and nicotine addiction

Comptes Rendus - Biologies

Volumn 332, Issue 5, 2009, Pages 421-425

  Changeux, Jean Pierre ^a,b  

^a INSTITUT PASTEUR   (France)

^b l'alimentation et l'Environnement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NICOTINE; NICOTINIC RECEPTOR;

ALKALOID; SMOKING; TOBACCO;

ARTICLE; BINDING SITE; CANCER RISK; DISEASE PREDISPOSITION; FRONTAL CORTEX; GENE EXPRESSION; HUMAN; LUNG CANCER; MOLECULAR MECHANICS; NEUROTRANSMITTER RELEASE; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TOBACCO DEPENDENCE; VENTRAL TEGMENTUM;

ACETYLCHOLINE; ADOLESCENT; ADULT; ALLOSTERIC REGULATION; ANIMALS; BRAIN CHEMISTRY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ION CHANNELS; LUNG NEOPLASMS; MICE; NICOTINE; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC; REWARD; SMOKING; SYNAPTIC TRANSMISSION; TOBACCO USE DISORDER; TORPEDO; VENTRAL TEGMENTAL AREA;

EID: 64849099374     PISSN: 16310691     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.crvi.2009.02.005     Document Type: Article

References (28)

1. Nachmansohn D. Chemical and Molecular Basis of Nerve Activity (1959), Academic Press, New York
2. C.Y. Lee, C.C. Chang, Mode of action of purified toxins from elapid venoms on neuromuscular transmission, in: Mem. Inst. Butantan, Sao Paulo, vol. 33, 1966, pp. 555-572
3. Changeux J.-P., Kasai M., and Lee C.Y. The use of a snake venom toxin to characterize the cholinergic receptor protein. Proc. Natl. Acad. Sci. USA 67 (1970) 1241-1247
4. Changeux J.-P., Kasai M., Huchet M., and Meunier J.-C. Extraction à partir du tissu électrique de gymnote d'une protéine présentant plusieurs propriétés caractéristiques du récepteur physiologique de l'acétylcholine. C. R. Acad. Sci. Paris, Ser. D 270 (1970) 2864-2867
5. Olsen R., Meunier J.C., and Changeux J.-P. Progress in purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography. FEBS Lett. 28 (1972) 96-100
6. Cartaud J., Benedetti E.L., Cohen J.B., Meunier J.C., and Changeux J.-P. Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata. FEBS Lett. 33 (1973) 109-113
7. Changeux J.P. The acetylcholine receptor: an "allosteric" membrane protein. Harvey Lectures vol. 75 (1981), Academic Press, New York 85-254
8. Changeux J.P. Functional architecture and dynamics of the nicotinic acetylcholine receptor: an allosteric ligand-gated ion channel. Fidia Research Foundation Neuroscience Award Lectures vol. 4 (1981), Raven Press, New York 21-168
9. Devillers-Thiéry A., Changeux J.-P., Paroutaud P., and Strosberg A.D. The amino-terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata. FEBS Lett. 104 (1979) 99-105
10. Noda M., Takahashi H., Tanabe T., Toyosato M., Furutani Y., Hirose T., Asai M., Inayama S., Miyata T., and Numa S. Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299 (1982) 793-797
11. Devillers-Thiéry A., Giraudat J., Bentaboulet M., and Changeux J.-P. Complete mRNA coding sequence of the acetylcholine binding alpha subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc. Natl. Acad. Sci. USA 80 (1983) 2067-2071
12. Brejc K., van Dijk W.J., Klaassen R.V., Schuurmans M., van Der Oost J., Smit A.B., and Sixma T.K. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411 6835 (2001) 269-276
13. Giraudat J., Dennis M., Heidmann T., Chang J.Y., and Changeux J.-P. Structure of the high affinity site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]-chlorpromazine. Proc. Natl. Acad. Sci. USA 83 (1986) 2719-2723
14. Imoto K., Busch C., Sakmann B., Mishina M., Konno T., Nakai J., Bujo H., Mori Y., Fukuda K., and Numa S. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature 335 (1988) 645-648
15. Changeux J.P. Sur les propriétés allostériques de la L-thréonine désaminase de biosynthèse. Bull. Soc. Chim. Biol. 46 (1964) 927-946 947-961, 1151-1173
16. Changeux J.P. Sur les propriétés allostériques de la L-thréonine désaminase de biosynthèse. Bull. Soc. Chim. Biol. 47 (1965) 115-139 267-280, 281-300
17. Changeux J.P. The feedback control mechanism of biosynthetic L-threonine deaminase by L-isoleucine. Cold Spring Harbor Symp. Quant. Biol. 26 (1961) 313-318
18. Monod J., Changeux J.-P., and Jacob F. Allosteric proteins and cellular control systems. J. Mol. Biol. 6 (1963) 306-329
19. Monod J., Wyman J., and Changeux J.-P. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12 (1965) 88-118
20. Bocquet N., Prado de Carvalho L., Cartaud J., Neyton J., Le Poupon C., Taly A., Grutter T., Changeux J.P., and Corringer P.J. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 445 (2007) 116-119
21. Bocquet N., Nury H., Baaden M., Le Poupon C., Changeux J.-P., Delarue M., and Corringer P.-J. X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457 (2009) 111-114
22. von Heijne G. The membrane protein universe: what's out there and why bother?. J. Intern. Med. 261 (2007) 543-557
23. Champtiaux N., and Changeux J.P. Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. Prog. Brain Res. 145 (2004) 235-251 (Review)
24. Maskos U., Molles B.E., Pons S., Besson M., Guiard B.P., Guilloux J.P., Evrard A., Cazala P., Cormier A., Mameli-Engvall M., Dufour N., Cloz-Tayarani I., Bemelmans A.-P., Mallet J., Gardier A.M., David V., Faure P., Granon S., and Changeux J.-P. Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436 (2005) 103-107
25. Thorgeirsson T.E., et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452 (2008) 638-642
26. Hung R.J., et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452 (2008) 633-637
27. Amos C.I., Wu X., Broderick P., Gorlov I.P., Gu J., Eisen T., Dong Q., Zhang Q., Gu X., Vijayakrishnan J., Sullivan K., Matakidou A., Wang Y., Mills G., Doheny K., Tsai Y.Y., Chen W.V., Shete S., Spitz M.R., and Houlston R.S. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet. 40 (2008) 616-622
28. Dehaene S., Kerszberg M., and Changeux J.-P. A neuronal model of a global workspace in effortful cognitive tasks. Proc. Natl. Acad. Sci. USA 95 (1998) 14529-14534