Effects of docosahexaenoic acid on large-conductance Ca2+ -activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells

Acta Pharmacologica Sinica

Volumn 30, Issue 3, 2009, Pages 314-320

  Lai, Li Hong ^a   Wang, Ru Xing ^b   Jiang, Wen Ping ^a   Yang, Xiang Jun ^a   Song, Jian Ping ^a   Li, Xiao Rong ^b   Tao, Guo ^c  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Docosahexaenoic acid; Large conductance Ca2+ activated K + channel; Patch clamp techniques; Smooth muscle cell; Voltage gated K+ channel

Indexed keywords

DOCOSAHEXAENOIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL; VOLTAGE DEPENDENT ANION CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; RAT; ROOM TEMPERATURE; VASODILATATION; ANIMAL; CORONARY BLOOD VESSEL; CYTOLOGY; DOSE RESPONSE; HISTOLOGY; METABOLISM; PHYSIOLOGY; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; CORONARY VESSELS; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, SPRAGUE-DAWLEY;

EID: 64849093672     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.7     Document Type: Article

References (19)

1. Mori TA, Watts GF, Burke V, Hilme E, Puddey IB, Beilin LJ. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 2000; 102: 1264-9.
2. Clemens von Schacky C, Harris WS. Cardiovascular benefits of omega-3 fatty acids. Cardiovasc Res 2007; 73: 310-5.
3. Engler MM, Engler MB, Pierson DM, Molteni LB, Molteni A. Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. Exp Biol Med (Maywood) 2003; 228: 299-307.
4. FrenouxJM, Prost ED, Belleville JL, Prost JL. A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. JNutr2001; 131: 39-45.
5. Robert HC. Molecular determinants of voltage-gated potassium currents in vascular smooth muscle. Cell Biochem Biophys 2005; 42: 167-95.
6. + channels: physiological role and pharmacology. Curr Med Chem 2003; 10: 649-61.
7. + channels: function, pharmacology and drugs. Curt Med Chem 2002; 9: l385-95.
8. + channels in vascular smooth muscle cells. J Smooth Muscle Res 2008; 44: 65-81.
9. Zhang Y, Oltman CL, Lu T, Lee HC, Dellsperger KC, VanRollins M. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. Am J Physiol Heart Circ Physiol 2001; 280: 2430-40.
10. + channels: subunit selective antagonism by zinc. Neuropharmacology 1996; 35: 969-82.
11. Wu KT, Huang CT, Wei J, Tsait LM, Hsu CH, Chen YC, et al. Vasodilator action of docosahexaenoic acid (DHA) in human coronary arteries in vitro. Chin J Physiol 2007; 50: 164-70.
12. Ye D, Zhang D, Oltman C, Dellsperger K, Lee HC, VanRollins M. Cytochrome P-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. J Pharmacol Exp Ther 2002; 303: 768-76.
13. + channels in coronary arterial smooth muscle cells in Zucker diabetic fatty rats. Diabetes 2005; 54: 2155-63.
14. + channels in vascular endothelial cells. Biol Chem 2005; 3: 11656-64.
15. Bubolz AH, Li HW, Wu QP, Liu YP. Enhanced oxidative stress impairs cAMP-mediated dilation by reducing KV channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 2005; 289: H1873-H1880.
16. + channels of rat arterial smooth muscle. Am J Physiol Heart Circ Physiol 2001; 281: H2480-H2489.
17. Cox RH, Rusch NJ. New expression profiles of voltage-gated ion channels in arteries exposed to high blood pressure. Micro-circulation 2000; 29: 243-57.
18. Tanaka Y, Koike K, Toro L. MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms. J Smooth Muscle Res 2004; 40:125-53.
19. + (BK)