Prevalence and molecular characteristics of Staphylococcus aureus isolates colonizing patients with atopic dermatitis and their close contacts in Singapore

British Journal of Dermatology

Volumn 160, Issue 5, 2009, Pages 965-971

  Chiu, L S ^a   Ho, M S L ^a   Hsu, L Y ^b   Tang, M B Y ^a  

^a NATIONAL SKIN CENTRE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Atopic eczema; Family contacts; Nasal colonization; S. aureus enterotoxin

Indexed keywords

STAPHYLOCOCCUS ENTEROTOXIN B; VIRULENCE FACTOR;

ADOLESCENT; ADULT; ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CHILD; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NOSE SMEAR; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SINGAPORE; STAPHYLOCOCCUS AUREUS;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COLONY COUNT, MICROBIAL; CROSS-SECTIONAL STUDIES; DERMATITIS, ATOPIC; FAMILY; FEMALE; HUMANS; MALE; NASAL MUCOSA; PREVALENCE; SEVERITY OF ILLNESS INDEX; SINGAPORE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS; YOUNG ADULT;

EID: 64849086705     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09038.x     Document Type: Article

References (28)

1. Tay YK, Kong KH, Khoo L et al. The prevalence and descriptive epidemiology of atopic dermatitis in Singapore school children. Br J Dermatol 2002 146 : 101 6.
2. Bieber T. Atopic dermatitis. N Engl J Med 2008 358 : 1483 94.
3. Guttman-Yassky E. Atopic dermatitis. Curr Probl Dermatol 2007 35 : 154 72.
4. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003 361 : 151 60.
5. Kluytmans J, van Belkum A, Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 1997 10 : 505 20.
6. O'Regan GM, Irvine AD. The role of filaggrin loss-of-function mutations in atopic dermatitis. Curr Opin Allergy Clin Immunol 2008 8 : 406 10.
7. Howell MD, Fairchild HR, Kim BE et al. Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol 2008 128 : 2248 58.
8. Kim BE, Leung DY, Boguniewicz M, Howell MD. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol 2008 126 : 332 7.
9. Leung D. Superantigens, steroid insensitivity and innate immunity in atopic eczema. Acta Derm Venereol Suppl (Stockh) 2005 215 : 11 15.
10. Mempel M, Lina G, Hojka M et al. High prevalence of superantigens associated with the egc locus in Staphylococcus aureus isolates from patients with atopic eczema. Eur J Clin Microbiol Infect Dis 2003 22 : 306 9.
11. Breuer K, Wittmann M, Bösche B et al. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy 2000 55 : 551 5.
12. Zollner TM, Wichelhaus TA, Hartung A et al. Colonization with superantigen-producing Staphylococcus aureus is associated with increased severity of atopic dermatitis. Clin Exp Allergy 2000 30 : 994 1000.
13. Cardona ID, Cho SH, Leung DY. Role of bacterial superantigens in atopic dermatitis: implications for future therapeutic strategies. Am J Clin Dermatol 2006 7 : 273 9.
14. Gong JQ, Lin L, Lin T et al. Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial. Br J Dermatol 2006 155 : 680 7.
15. Breuer K, Haussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 2002 147 : 55 61.
16. Lever R, Hadley K, Downey D, Mackie R. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy. Br J Dermatol 1988 119 : 189 98.
17. Gilani SJ, Gonzalez M, Hussain I et al. Staphylococcus aureus re-colonization in atopic dermatitis: beyond the skin. Clin Exp Dermatol 2005 30 : 10 13.
18. Bonness S, Szekat C, Novak N, Bierbaum G. Pulsed-field gel electrophoresis of Staphylococcus aureus isolates from atopic patients revealing presence of similar isolates in isolates from children and their parents. J Clin Microbiol 2008 46 : 456 61.
19. European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1993 186 : 23 31.
20. Kunz B, Oranje AP, Labrèze L et al. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997 195 : 10 19.
21. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. Suppl. M100-S14, Vol. 24, Wayne, PA : CLSI, 2005.
22. Jarraud S, Mougel C, Thioulouse J et al. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun 2002 70 : 631 41.
23. Sabat A, Krzyszton-Russjan J, Strzalka W et al. New method for typing Staphylococcus aureus isolates: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates. J Clin Microbiol 2003 41 : 1801 4.
24. Goh CL, Wong JS, Giam YC. Skin colonization of Staphylococcus aureus in atopic dermatitis patients seen at the National Skin Centre, Singapore. Int J Dermatol 1997 36 : 653 7.
25. Hon KL, Lam MC, Leung TF et al. Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis. Ann Acad Med Singapore 2005 34 : 602 5.
26. Lomholt H, Andersen KE, Kilian M. Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis. J Invest Dermatol 2005 125 : 977 82.
27. Wijaya L, Hsu LY, Kurup A. Community-associated methicillin-resistant Staphylococcus aureus: overview and local situation. Ann Acad Med Singapore 2006 35 : 479 86.
28. Schlievert PM, Case LC, Strandberg KL et al. Superantigen profile of Staphylococcus aureus isolates from patients with steroid resistant atopic dermatitis. Clin Infect Dis 2008 46 : 1562 7.