Improvement of FR901379 production by mutant selection and medium optimization

Journal of Bioscience and Bioengineering

Volumn 107, Issue 5, 2009, Pages 530-534

  Kanda, Munekazu ^a   Tsuboi, Masaru ^a   Sakamoto, Kazutoshi ^a   Shimizu, Shiho ^a   Yamashita, Michio ^a   Honda, Hiroyuki ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Antibiotics; Fermentation; Medium design; Mutation; Screening

Indexed keywords

A CARBONS; ALBICANS; AMMONIUM SULFATES; CHLORIDE CONTENTS; COLONY SIZES; CONCENTRATION OF; ECHINOCANDIN; FOURTH GENERATIONS; LIPOPEPTIDE; LOW CONCENTRATIONS; MAGNESIUM SULFATES; MEDIUM DESIGN; MEDIUM OPTIMIZATIONS; MUTATION; NITROGEN SOURCES; PHOSPHATE SALTS; PRODUCTION MEDIUMS; SELECTION MARKERS; SHRINKING RATES; SOLUBLE STARCHES; WILD TYPES; WILD-TYPE STRAINS;

AMMONIUM COMPOUNDS; ANTIBIOTICS; BIOCHEMICAL ENGINEERING; CHEMICAL MODIFICATION; FERMENTATION; MAGNESIUM; POLYSACCHARIDES; SHRINKAGE; SODIUM CHLORIDE; STARCH;

STRAIN;

AMMONIUM SULFATE; CARBON; FR 901379; MAGNESIUM SULFATE; PHOSPHATE; POLYPEPTIDE ANTIBIOTIC AGENT; SODIUM CHLORIDE; STARCH; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; DRUG DESIGN; DRUG SCREENING; FUNGAL COLONIZATION; FUNGAL STRAIN; NONHUMAN;

ASCOMYCOTA; BIOREACTORS; CELL CULTURE TECHNIQUES; GENETIC ENHANCEMENT; MUTATION; PEPTIDES, CYCLIC; SPECIES SPECIFICITY;

COLEOPHOMA EMPETRI;

EID: 64749110385     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.01.002     Document Type: Article

References (15)

1. Benz F., Knuel F., Nuesch J., Treichler H., and Voser W. Echinocandin B, ein neuartiges Polipeptid-Antibiotikum aus Aspergillus nidulans var. echinatus: Isolierung und Bausteine. Helv. Chim. Acta 57 (1974) 2459-2477
2. Mizuno K., Yagi A., Satoi S., Takada M., Hayashi M., Asano K., and Matsuda T. Studies on aculeacin. I. Isolation and characterization of aculeacin A. J. Antibiotics 30 (1977) 297-302
3. Roy K., Mukhopadhyay T., C.S. Reddy G., R. Desikan K., and N. Ganguli B. Mulundocandin, a new lipopeptide antibiotic. I. Taxonomy, fermentation, isolation and characterization. J. Antibiotics 40 (1987) 275-280
4. Schwartz R.E., Sesin D.F., Joshua H., Wilson K.E., Kempf J., Goklen K.A., Kuehner D., Gailliot P., Gleason C., White R., Inamine E., Bills G., Salmon P., and Zitano L. Pneumocandins from Zalerion arboricola. I. Discovery and isolation. J. Antibiotics 45 (1992) 1853-1866
5. Schwartz R.R., Giacobbe R.A., Bland J.A., and Monaghan R.L. L-671,329, A new antifungal agent. I. Fermentation and isolation. J. Antibiotics 42 (1989) 163-167
6. Iwamoto T., Fujie A., Sakamoto K., Tsurumi Y., Shigematsu N., Yamashita M., Hashimoto S., Okuhara M., and Kohsaka M. WF11899A, B and C, Novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties. J. Antibiotics 47 (1994) 1084-1091
7. rd ICAAC, No.F37 (1993), New Orleans, USA
8. Yamashita M., Matsuda M., Oohata N., Kanda M., and Higaki T. Study of industrial manufacturing methods for Micafungin (FK463). Seibutsu-kogaku 83 (2005) 123-131
9. Ichikura T., Date M., Ishikura T., and Ozaki A. Improvement of kasugamycin-producing strain by the agar piece method and the prototroph method. Folia Microbiol. 16 (1971) 218-224
10. Demain A.L. Mutation and the production of secondary metabolites. Adv. Appl. Microbiol. 16 (1973) 177-202
11. Masurekar P.S., Fountoulakis J.M., Hallada T.C., Sosa M.S., and Kaplan L. Pneumocandins from Zalerion arboricola II. Modification of product spectrum by mutation and medium manipulation. J. Antibiotics 45 (1992) 1867-1874
12. Takebe H., Hiruta O., Satoh A., Kataoka H., and Tanaka H. Studies on the industrial production of Bialaphos. Seibutsu-kogaku 73 (1995) 413-424
13. Martin J.F., and Demain A.L. Control of antibiotic biosynthesis. Microbiol. Rev. 44 (1980) 230-251
14. Martin J.F. Control of antibiotic synthesis by phosphate. Adv. Biochem. Eng. 6 (1977) 105-127
15. Kishimoto K., Park Y.S., Okabe M., and Akiyama S. Effect of phosphate ion on Mildiomycin production by Streptoverticillium rimofaciens. J. Antibiotics 49 (1996) 775-780