Stem cell factor prevents neuronal cell apoptosis after acute spinal cord injury

Spine

Volumn 34, Issue 4, 2009, Pages 323-327

  Yamasaki, Kouhei ^a   Setoguchi, Takao ^a   Takenouchi, Takeshi ^a   Yone, Kazunori ^b   Komiya, Setsuro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Spinal cord injury; Stem cell factor

Indexed keywords

CASPASE 3; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; MESSENGER RNA; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; UPREGULATION; ACUTE DISEASE; ANIMAL; DISEASE MODEL; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NERVE DEGENERATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; WISTAR RAT;

ACUTE DISEASE; ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD INJURIES; STEM CELL FACTOR; TIME FACTORS; UP-REGULATION;

EID: 64749105632     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318193a1de     Document Type: Article

References (24)

1. Crowe MJ, Bresnahan JC, Shuman SL, et al. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3:73-6.
2. Liu XZ, Xu XM, Hu R, et al. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 1997;17:5395-406.
3. Wada S, Yone K, Ishidou Y, et al. Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist. J Neurosurg 1999;91:98-104.
4. Konig A, Corbacioglu S, Ballmaier M, et al. Downregulation of c-kit expression in human endothelial cells by inflammatory stimuli. Blood 1997;90: 148-55.
5. Keshet E, Lyman SD, Williams DE, et al. Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. Embo J 1991;10:2425-35.
6. Erlandsson A, Larsson J, Forsberg-Nilsson K. Stem cell factor is a chemoat-tractant and a survival factor for CNS stem cells. Exp Cell Res 2004;301: 201-10.
7. Nakahara S, Yone K, Sakou T, et al. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. J Neuropathol Exp Neurol 1999;58:442-50.
8. Arishima Y, Setoguchi T, Yamaura I, et al. Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats. Spine 2006;31:2432-8.
9. Morstyn G, Brown S, Gordon M, et al. Stem cell factor is a potent synergistic factor in hematopoiesis. Oncology 1994;51:205-14.
10. Broxmeyer HE, Maze R, Miyazawa K, et al. The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells 1991;3:480-7.
11. Sakanaka M, Wen TC, Matsuda S, et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci U S A 1998;95: 4635-40.
12. Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A 2000;97:10526 -31.
13. Schabitz WR, Kollmar R, Schwaninger M, et al. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 2003;34:745-51.
14. Shyu WC, Lin SZ, Lee CC, et al. Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial. CMAJ 2006; 174:927-33.
15. Chin-Yee IH, Keeney M, Stewart AK, et al. Optimising parameters for peripheral blood leukapheresis after r-metHuG-CSF (filgrastim) and r-metHuSCF (ancestim) in patients with multiple myeloma: a temporal analysis of CD34(+) absolute counts and subsets. Bone Marrow Transplant 2002;30:851-60.
16. Duarte RF, Frank DA. SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 2000;96:3422-30.
17. Zhang SC, Fedoroff S. Cellular localization of stem cell factor and c-kit receptor in the mouse nervous system. J Neurosci Res 1997;47:1-15.
18. Bredesen DE, Rao RV, Mehlen P. Cell death in the nervous system. Nature 2006;443:796-802.
19. Grasso G, Sfacteria A, Passalacqua M, et al. Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Neurosurgery 2005;56:821-7; discussion 821-7.
20. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 1998;8:779-82.
21. Engstrom M, Karlsson R, Jonsson JI. Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp Hematol 2003;31:316-23.
22. Matsui J, Wakabayashi T, Asada M, et al. Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells. J Biol Chem 2004;279:18600-7.
23. Linnekin D. Early signaling pathways activated by c-Kit in hematopoietic cells. Int J Biochem Cell Biol 1999;31:1053-74.
24. Dhandapani KM, Wade FM, Wakade C, et al. Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB. J Neurochem 2005;95:9-19.