Methotrexate Clearance by High-Flux Hemodialysis and Peritoneal Dialysis: A Case Report

American Journal of Kidney Diseases

Volumn 53, Issue 5, 2009, Pages 871-874

  Murashima, Miho ^a   Adamski, Jill ^a   Milone, Michael C ^a   Shaw, Leslie ^a   Tsai, Donald E ^a   Bloom, Roy D ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

clearance; high flux hemodialysis; Methotrexate; peritoneal dialysis

Indexed keywords

FOLINIC ACID; METHOTREXATE; RITUXIMAB; TEMOZOLOMIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; CATHETER INFECTION; CATHETER OCCLUSION; CHRONIC KIDNEY DISEASE; CONTINUOUS INFUSION; CRANIOTOMY; CREATININE CLEARANCE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; HEMODIALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; LARGE CELL LYMPHOMA; MALE; MULTIPLE CYCLE TREATMENT; PERITONEAL DIALYSIS; VASCULAR ACCESS;

DIALYSIS SOLUTIONS; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; METABOLIC CLEARANCE RATE; METHOTREXATE; MIDDLE AGED; PERITONEAL DIALYSIS;

EID: 64749103448     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.01.016     Document Type: Article

References (18)

1. Brunton L.L., Lazo J.S., and Parker K. Goodman and Gilman's the Pharmacological Basis of Therapeutics (ed 11) (2006), McGraw Hill, Hightstown, NJ
2. Boulanger H., Launay-Vacher V., Hierniaux P., Fau J.B., and Deray G. Severe methotrexate intoxication in a haemodialysis patient treated for rheumatoid arthritis. Nephrol Dial Transplant 16 (2001) 1087 (letter)
3. Chess J.A., Scholey G., and Mikhail A.I. Neutropenia associated with the use of low-dose methotrexate in a peritoneal dialysis patient. Nephrol Dial Transplant 19 (2004) 2158-2159
4. Yang C.P., Kuo M.C., Guh J.Y., and Chen H.C. Pancytopenia after low dose methotrexate therapy in a hemodialysis patient: Case report and review of literature. Ren Fail 28 (2006) 95-97
5. Hande K.R., Balow J.E., Drake J.C., Rosenberg S.A., and Chabner B.A. Methotrexate and hemodialysis. Ann Intern Med 87 (1977) 495-496
6. Molina R., Fabian C., and Cowley B. Use of charcoal hemoperfusion with sequential hemodialysis to reduce serum methotrexate levels in a patient with acute renal insufficiency. Am J Med 82 (1987) 350-352
7. Relling M.V., Stapleton B., Ochs J., et al. Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion. Cancer 62 (1988) 884-888
8. Wall S.M., Johansen M.J., Molony D.A., DuBose T.D., Jaffe N., and Madden T. Effective clearance of methotrexate using high-flux hemodialysis membranes. Am J Kidney Dis 28 (1996) 846-854
9. Saland J.M., Leavey P.J., Bash R.O., Hansch E., Arbus G.S., and Quigley R. Effective removal of methotrexate by high-flux hemodialysis. Pediatr Nephrol 17 (2002) 825-829
10. Batchelor T., and Loeffler J.S. Primary CNS lymphoma. J Clin Oncol 24 (2006) 1281-1288
11. Pels H., Schmidt-Wolf I., Glasmacher A., et al. Primary central nervous system lymphoma: Results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol 21 (2003) 4489-4495
12. Enting R.H., Demopoulos A., DeAngelis L.M., and Abrey L.E. Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide. Neurology 63 (2004) 901-903
13. Batchelor T., Carson K., O'Neill A., et al. Treatment of pimary CNS lymphoma with methotrexate and deferred radiotherapy: A report of NABTT 96-07. J Clin Oncol 21 (2003) 1044-1049
14. Chabner B.A., and Longo D.L. Cancer Chemotherapy & Biotherapy. Principles and Practice. (ed 4) (2006), Lippincott Williams & Wilkins, Philadelphia, PA
15. Atkinson A.J., Abernethy D.R., Daniels C.E., Dedriek R.L., and Markey S.P. Principles of Clinical Pharmacology. (ed 2) (2007), Elsevier, Burlington, MA
16. Ahmad S., Shen F., and Bleyer W.A. Methotrexate-induced renal failure and ineffectiveness of peritoneal dialysis. Arch Intern Med 138 (1978) 1146-1147
17. Diskin C.J., Stokes T.J., Dansby L.M., Radcliff L., and Carter T.B. Removal of methotrexate by peritoneal dialysis and hemodialysis in a single patient with end-stage renal disease. Am J Med Sci 332 (2006) 156-158
18. Steinberg S.E., Campbell C.L., Bleyer W.A., and Hillman R.S. Enterohepatic circulation of methotrexate in rats in vivo. Cancer Res 42 (1982) 1279-1282