Investigation of gastric and duodenal mucosal defects caused by low-dose aspirin in patients with ischemic heart disease

Journal of Clinical Gastroenterology

Volumn 43, Issue 2, 2009, Pages 130-132

  Nema, Hiroaki ^a   Kato, Mototsugu ^b   Katsurada, Takehiko ^b   Nozaki, Youichi ^a   Yotsukura, Akihiko ^a   Yoshida, Izumi ^a   Sato, Katsuhiko ^a   Kawai, Yuko ^a   Takagi, Yasushi ^a   Okusa, Takanori ^a   Takiguchi, Shunichi ^c,d   Sakurai, Masayuki ^a   Asaka, Masahiro ^c  

^a Hokko Memorial Hospital   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Japan Ground Self Defense Force 11th Logistic Regiment Medical Unit   (Japan)

Author keywords

Buffered formulation; Enteric coated formulation; Ischemic heart disease; Low dose aspirin; Mucosal defects

Indexed keywords

ACETYLSALICYLIC ACID; BAYASPIRIN; UNCLASSIFIED DRUG; BUFFER; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DUODENUM MUCOSA; ENTERIC COATED TABLET; GASTRODUODENAL ULCER; GASTROINTESTINAL ENDOSCOPY; HUMAN; ISCHEMIC HEART DISEASE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SECONDARY PREVENTION; STOMACH MUCOSA; AGED; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; DUODENUM; FEMALE; GASTROINTESTINAL DISEASE; HEART MUSCLE ISCHEMIA; INTESTINE MUCOSA; MALE; MIDDLE AGED; PATHOLOGY;

AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BUFFERS; DRUG ADMINISTRATION SCHEDULE; DUODENUM; ENDOSCOPY, GASTROINTESTINAL; FEMALE; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; TABLETS, ENTERIC-COATED;

EID: 64749098146     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181580e8a     Document Type: Article

References (15)

1. Collaborative overview of randomised trials of antiplatelet therapy-I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ. 1994;308:81-106.
2. Muramatsu A, Azuma T, Okajima T, et al. Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan. Aliment Pharmacol Ther. 2004;20(suppl 1):102-106. (Pubitemid 39120280)
3. Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Eng J Med. 1991;325: 1593-1596.
4. Anderson KE, Johnson TW, Lazovich D, et al. Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer. J Natl Cancer Inst. 2002;94: 1168-1171. (Pubitemid 34919054)
5. Kelly JP, Kaufman DW, Jurgelon JM, et al. Risk of aspirinassociated major upper-gastrointestinal bleeding with entericcoated or buffered product. Lancet. 1996;348:1413-1416.
6. Banoob DW, McCloskey WW, Webster W. Risk of gastric injury with enteric- versus nonenteric-coated aspirin. Ann Pharmacother. 2002;36:163-166. (Pubitemid 34052959)
7. Colwell JA, Nesto RW. The platelet in diabetes: focus on prevention of ischemic events. Diabetes Care. 2003;26:2181-2188.
8. Albers GW, Hart RG, Lutsep HL, et al. AHA Scientific Statement. Supplement to the guidelines for the management of transient ischemic attacks: a statement from the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association. Stroke. 1999;30:2502-2511.
9. Gordon JL, Pearson JD. Effects of sulphinpyrazone and aspirin on prostaglandin I2 (prostacyclin) synthesis by endothelial cells. Br J Pharmacol. 1978;64:481-483. (Pubitemid 9098880)
10. Burke A, Smyth E, FitzGerald GA. Goodman & Gilman's the Pharmacological Basis of Therapeutics. 11th ed. New York: McGraw-Hill; 2007:671-715.
11. Bochner F, Siebert DM, Rodgers SE, et al. Measurement of aspirin concentrations in portal and systemic blood in pigs: effect on platelet aggregation, thromboxane and prostacyclin production. Thromb Haemost. 1989;61:211-216. (Pubitemid 19124391)
12. Gartner AH. Aspirin-induced gastritis and gastrointestinal bleeding. J Am Dent Assoc. 1976;93:111-117.
13. Leung WK, Bjarnason I, Wong VW, et al. Small bowel enteropathy associated with chronic low-dose aspirin therapy. Lancet. 2007;369:614. (Pubitemid 46241446)
14. Rodriguez LAG, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet. 1994;343:769-772. (Pubitemid 24098698)
15. Lai KC, Lam SK, Chu KM, et al. Lansoprazole for the prevention of recurrences of ulcer complications from longterm low-dose aspirin use. N Engl J Med. 2002;346:2033-2038. (Pubitemid 34680594)