Delayed diagnosis of HIV infection in a multicenter cohort: Prevalence, risk factors, response to HAART and impact of mortality

Current HIV Research

Volumn 7, Issue 2, 2009, Pages 224-230

  Sobrino Vegas, Paz ^a   García San Miguel, Lucía ^b   Caro Murillo, Ana M ^a   Miro, José M ^c   Viciana, Pompeyo ^d   Tural, Cristina ^e   Saumoy, Maria ^f   de los Santos, Ignacio ^g   Sola, Julio ^h   del Amo, Julia ^a   Moreno, Santiago ^b   Podnzamczer, Daniel ^f   Ferrer, Elena ^f   Saumoy, María ^f   Olmo, Montserrat ^f   Méndez, Concepción Faz ^f   Vila, Antonia ^f   Barragán, Patricia ^f   Peña, Carmen ^f   del Carmen Cabellos, María ^f   Bolao, Ferrán ^f   Sánchez, Pochita ^f   Gómez Sirvent, Juan Luis ⁱ   Rodríguez Fortúnez, Patricia ⁱ   Alemán Valls, María Remedios ⁱ   del Mar Alonso Socas, María ⁱ   López Lirola, Ana María ⁱ   Hernández Hernández, María Inmaculada ⁱ   Soriano, Vicente ^j   Labarga, Pablo ^j   Barreiro, Pablo ^j   Medrano, José ^j   Rivas, Pablo ^j   Herrero, Dolores ^j   Blanco, Francisco ^j   Vispo, Ma Eugenia ^j   Carbonero, Luz Martín ^j   Ramirez, Germán ^j   de Diego, Marcedes ^j   Miró, José M ^k   García, José Fernando ^k   Agüero, Fernando ^k   Manzardo, Christian ^k   Zamora, Laura ^k   Gil, Cristina ^k   Blanco, José Luis ^k   García Alcaide, Felipe ^k   Martínez, Esteban ^k   Mallolas, Josep ^k   Lópe Dieguez, María ^k   Gatell, José M ^k   Rubio, Rafael ^l   Pulido, Federico ^l   Cuerda, Víctor Moreno ^l   Cepeda, Concepción ^l   Hervás, Rafael ^l   Iribarren, José Antonio ^m   Arrizabalaga, Julio ^m   Aramburu, María José ^m   Camino, Xabier ^m   Rodríguez Arrondo, Francisco ^m   von Wichmann, Miguel Ángel ^m   Tomé, Lidia Pascual ^m   Goenaga, Miguel Ángel ^m   Gutiérrez, Félix ⁿ   Masiá, Mar ⁿ   Ramos, José Manuel ⁿ   Padilla, Sergio ⁿ   Sánchez Hellín, Victoria ⁿ   Bernal, Enrique ⁿ   Escolano, Clara ⁿ   Montolio, Fernando ⁿ   Peral, Yolanda ⁿ   Clotet, Bonaventura ^e   Ruiz, Lidia ^e   Miranda, Cristina ^e   Berenguer, Juan ^o   López Bernaldo de Quirós, Juan Carlos ^o   Miralles, Pillar ^o   Cosín Ochaíta, Jaime ^o   Sánchez Conde, Matilde ^o   Gutiérrez Cuellar, Isabel ^o   Ramírez Schacke, Margarita ^o   Padilla Ortega, Belén ^o   Vidal, Francesc ^p   Sanjuan, Marta ^p   Peraire, Joaquín ^p   Veloso, Sergio ^p   Viladés, Consuelo ^p   López Dupla, Miguel ^p   Olona, Montserrat ^p   Vargas, Montserrat ^p   Lópes Aldeguer, José ^q   Juliá, Marino Blanes ^q   Rodrigo, José Lacruz ^q   Salavert, Miguel ^q   Montero, Marta ^q   Cuéllar, Sandra ^q   Sanz, Jesús Sanz ^g   Oteo, José Antonio ^r   Blanco, José Ramón ^r   Ibarra, Valvanera ^r   Metola, Luis ^r   Sanz, Mercedes ^r   Pérez Martínez, Laura ^r   Uriz, Javier ^h   Castiello, Jesús ^h   Reparaz, Jesús ^h   Arriaza, María Jesús ^h   Carmen, Irigoyen ^h   Segura, Ferrán ^s   Amengual, María José ^s   Penelo, Eva ^s   Navarro, Gemma ^s   Sala, Montserrat ^s   Cervantes, Manuel ^s   Pineda, Valentín ^s   Antela, Antonio ^b   Casado, José Luis ^b   Dronda, Fernando ^b   Moreno, Ana ^b   Pérez Elías, María José ^b   López, Dolores ^b   Gutiérrez, Carolina ^b   Hernández, Beatriz ^b   Pumares, María ^b   Martí, Paloma ^b   Page Alonso, Carmen ^b   García García, Federico ^t   Hernández Quero, José ^t   Peña Monje, Alejandro ^t   Muñoz Medina, Leopoldo ^t   Ruiz, Jorge Parra ^t   Riera, Melchor ^u   Murillas, Javier ^u   Vician, Pompeyo ^d   Leal, Manuel ^d   López Cortés, Luis Fernando ^d   Trastoy, Mónica ^d   Alcázar Caballero, Rosario Mata ^d   more..

^a CARLOS III INSTITUTE OF HEALTH   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^e HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^f HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^g HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^h Instituto de Investigación Sanitaria de Navarra   (Spain)

ⁱ HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^j HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^k HOSPITAL CLÍNIC   (Spain)

^l HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^m HOSPITAL DONOSTIA   (Spain)

ⁿ HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^o HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^p HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^q HOSPITAL UNIVERSITARIO LA FE   (Spain)

^r HOSPITAL SAN PEDRO   (Spain)

^s HOSPITAL DE SABADELL   (Spain)

^t HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^u HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

more..

Author keywords

Antiretroviral therapy; Cohort study; Early diagnosis; HIV; Late HIV diagnosis; Late presentation

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; AGE DISTRIBUTION; CD4 LYMPHOCYTE COUNT; DELAYED DIAGNOSIS; DRUG RESPONSE; EDUCATIONAL STATUS; FEMALE; HETEROSEXUALITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; MORTALITY; PREVALENCE; PROSPECTIVE STUDY; REVIEW; RISK FACTOR; SEX DIFFERENCE; SURVIVAL RATE; ARTICLE; COHORT ANALYSIS; MIDDLE AGED; SPAIN; SURVIVAL; TIME;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SPAIN; SURVIVAL ANALYSIS; TIME FACTORS; YOUNG ADULT;

EID: 64749095404     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016209787581535     Document Type: Review

References (31)

1. Castilla J, Lorenzo JM, Izquierdo A, et al. Characteristics and trends of newly diagnosed HIV-infections, 2000-2004. Gac Sanit 2006; 20(6): 442-8.
2. Castilla J, Sobrino P, de la Fuente L, et al. Late diagnosis of HIV infection in the era of highly active antiretroviral therapy: consequences for AIDS incidence. AIDS 2002; 16(14): 1945-51.
3. Teira CR, Suarez LI, Santamaria-Jauregui JM, et al. Delayed diagnosis of HIV infection in the Spanish VACH cohort [1997-2002]. Gac Sanit 2007; 21(1): 66-9.
4. [HIV Surveillance in Spain. Assessing New HIV Cases in Spain from Autonomous Communities Notification Systems: 2003-2006 period]. Available at: http://www.isciii.es/htdocs/centros/epidemiologia/ epi_sida.jsp, [accessed: 03/01/08].
5. Longo B, Pezzotti P, Boros S, Urciuoli R, Rezza G. Increasing proportion of late testers among AIDS cases in Italy, 1996-2002. AIDS Care 2005; 17(7): 834-41.
6. Girardi E, Aloisi MS, Arici C, et al. Delayed presentation and late testing for HIV: demographic and behavioral risk factors in a multicenter study in Italy. J Acquir Immune Defic Syndr 2004; 36(4): 951-9.
7. Delpierre C, Cuzin L, Lauwers-Cances V, Marchou B, Lang T. High-Risk groups for late diagnosis of HIV infection: a need for rethinking testing policy in the general population. AIDS Patient Care STDS 2006; 20(12): 838-47.
8. Delpierre C, Dray-Spira R, Cuzin L, et al. Correlates of late HIV diagnosis: implications for testing policy. Int J STD AIDS 2007; 18(5): 312-7
9. Chadborn TR, Delpech VC, Sabin CA, Sinka K, Evans BG. The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000-2004). AIDS 2006; 20(18): 2371-9.
10. Santos J, Palacios R, Gutierrez M, et al. HIV infection in the era of highly active antiretroviral therapy: the Malaga Study. Int J STD AIDS 2004; 15(9): 594-6.
11. Mayben JK, Kramer JR, Kallen MA, Franzini L, Lairson DR, Giordano TP. Predictors of delayed HIV diagnosis in a recently diagnosed cohort. AIDS Patient Care STDS 2007; 21(3): 195-204.
12. Lanoy E, Mary-Krause M, Tattevin P, et al. Frequency, determinants and consequences of delayed access to care for HIV infection in France. Antivir Ther 2007; 12(1): 89-96.
13. Fisher M. Late diagnosis of HIV infection: major consequences and missed opportunities. Curr Opin Infect Dis 2008; 21(1): 1-3.
14. Girardi E, Sabin CA, Monforte AD. Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing. J Acquir Immune Defic Syndr 2007; 46 (Suppl 1): S3-S8.
15. GESIDA and Spanish AIDS Plan Task Force. Recommendations from the GESIDA/ Spanish AIDS Plan regarding antiretroviral treatment in adults with human immunodeficiency virus infection (update January 2007). Enferm Infecc Microbiol Clin 2007; 25(1): 32-53.
16. Manzardo C, Zaccarelli M, Aguero F, Antinori A, Miro JM. Optimal timing and best antiretroviral regimen in treatment-naive HIV-infected individuals with advanced disease. J Acquir Immune Defic Syndr 2007; 46 (Suppl 1): S9-18.
17. Soria A, Lazzarin A. Antiretroviral treatment strategies and immune reconstitution in treatment-naive HIV-infected patients with advanced disease. J Acquir Immune Defic Syndr 2007; 46 (Suppl 1): S19-30.
18. Hall HI, McDavid K, Ling Q, Sloggett A. Determinants of progression to AIDS or death after HIV diagnosis, United States, 1996 to 2001. Ann Epidemiol 2006; 16(11): 824-33.
19. Aldaz P, Castilla J, Moreno-Iribas C, Irisarri F, Floristán Y, Sola-Boneta J. Trends in mortality and causes of death among persons with HIV infection, 1985-2004. Enferm Infecc Microbiol Clin 2007; 25(1): 5-10.
20. Centers for Disease Control and Prevention (CDC). Missed opportunities for earlier diagnosis of HIV infection-South Carolina, 1997-2005. MMWR Morb Mortal Wkly Rep 55(47); 1269-72.
21. Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Defic Syndr 2005; 39(4): 446-53.
22. Caro-Murillo AM, Castilla J, Perez-Hoyos S, et al. Spanish cohort of naive HIV-infected patients (CoRIS): rationale, organization and initial results. Enferm Infecc Microbiol Clin 2007; 25(1): 23-31.
23. Williams RL. A note on robust variance estimation for cluster-correlated data. Biometrics 2000; 56(2): 645-6
24. Schwarcz S, Hsu L, Dilley JW, Loeb L, Nelson K, Boyd S. Late diagnosis of HIV infection: trends, prevalence, and characteristics of persons whose HIV diagnosis occurred within 12 months of developing AIDS. J Acquir Immune Defic Syndr 2006; 43(4): 491-4.
25. Ministry of Health and Consumer Affairs, Secretariat of the National Plan on AIDS: HIV Infection and AIDS Multisectorial Plan, 2001-2005. Spain, July 2001. Available at: www.msc.es, consulted: 03/21/08.
26. Instituto Nacional de Estadística. Encuesta de salud y hábitos sexuales, 2003. Available at: http://www.ine.es/inebmenu /mnu_salud.htm. Consulted 03/01/08.
27. Frieden TR, Das-Douglas M, Kellerman SE, Henning KJ. Applying public health principles to the HIV epidemic. N Engl J Med 2005; 353(22): 2397-402.
28. Health Protection Agency. Migrant Health. Infectious diseases in non-UK born populations in England, Wales and Northern Ireland. A baseline report - 2006. Available at: http://www.hpa.org.uk/pub lications/2006/ migrant_health/default.htm. Consulted: 03/01/08.
29. Manfredi R, Calza L, Chiodo F. HIV-infected immigrants from non-European Union countries and antiretroviral treatment: comparison of epidemiologic, clinical, and therapeutic variables according to patient sex. J Acquir Immune Defic Syndr 2003; 33(3): 408-10.
30. May M, Sterne JA, Sabin C, et al. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies. AIDS 2007; 21(9): 1185-97.
31. Zolopa A, Andersen L, Komarow L, et al. Immediate vs Deferred ART in the setting of acute AIDS-related opportunistic infections: final results of a ramdomized strategy trial. ACTG A5164. Paper 142 [abstract] 15th Conference on Retroviruses and opportunistic Infections (CROI). Boston, February 3-5, 2008. Available at: http://www.retroconference.org/ 2008/Abstracts/32805.htm. Consulted: 10/02/08.