Abnormal LDIflare but normal quantitative sensory testing and dermal nerve fiber density in patients with painful diabetic neuropathy

Diabetes Care

Volumn 32, Issue 3, 2009, Pages 451-455

  Krishnan, Singhan T M ^a   Quattrini, Cristian ^b   Jeziorska, Maria ^b   Malik, Rayaz A ^b   Rayman, Gerry ^a  

^a IPSWICH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMAL NERVE FIBER DENSITY; DIABETIC NEUROPATHY; DIABETIC PATIENT; DIAGNOSTIC VALUE; FEMALE; HUMAN; INTERMETHOD COMPARISON; LASER DOPPLER IMAGER FLARE; MALE; NERVE FIBER; NON INSULIN DEPENDENT DIABETES MELLITUS; QUANTITATIVE ANALYSIS; QUANTITATIVE SENSORY TESTING; REPRODUCIBILITY; SENSORY ANALYSIS;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; PAIN MEASUREMENT;

EID: 64749084854     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-1453     Document Type: Article

References (25)

1. Levitt NS, Stansberry KB, Wynchank S, Vinik AI: The natural progression of autonomic neuropathy and autonomic function tests in a cohort of people with IDDM. Diabetes Care 19:751-754, 1996
2. Celiker R, Basgoze O, Bayraktar M: Early detection of neurological involvement in diabetes mellitus. Electromyogr Clin Neurophysiol 36:29-35, 1996
3. Vinik AI, Erbas T, Stansberry KB, Pittenger GL: Small fiber neuropathy and neurovascular disturbances in diabetes mellitus. Exp Clin Endocrinol Diabetes 109: 451-473, 2001
4. Galer BS, Gianas A, Jensen MP: Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 47:123-128, 2000
5. Dyck PJ, O'Brien PC, Kosanke JL, Gillen DA, Karnes JL: A 4, 2, and 1 stepping algorithm for quick and accurate estimation of cutaneous sensation threshold. Neurology 43:1508-1512, 1993
6. Gruener G, Dyck PJ: Quantitative sensory testing: methodology, applications, and future directions. J Clin Neurophysiol 11: 568-583, 1994
7. Shy ME, Frohman EM, So YT, Arezzo JC, Cornblath DR, Giuliani MJ, Kincaid JC, Ochoa JL, Parry GJ, Weimer LH: Quantitative sensory testing: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 60:898-904, 2003
8. Gelber DA, Pfeifer MA, Broadstone VL, Munster EW, Peterson M, Arezzo JC, Shamoon H, Zeidler A, Clements R, Greene DA: Components of variance for vibratory and thermal threshold testing in normal and diabetic subjects. J Diabetes Complications 9:170-176, 1995
9. Rayman G, Malik RA, Sharma AK, Day JL: Microvascular response to tissue injury and capillary ultrastructure in the foot skin of type I diabetic patients. Clin Sci (Lond) 89:467-474, 1995
10. Krishnan ST, Rayman G: The LDIflare: a novel test of C-fiber function demonstrates early neuropathy in type 2 diabetes. Diabetes Care 27:2930-2935, 2004
11. Polydefkis M, Hauer P, Griffin JW, McArthur JC: Skin biopsy as a tool to assess distal small fiber innervation in diabetic neuropathy. Diabetes Technol Ther 3:23-28, 2001
12. Smith AG, Howard JR, Kroll R, Ramachandran P, Hauer P, Singleton JR, McArthur J: The reliability of skin biopsy with measurement of intraepidermal nerve fiber density. J Neurol Sci 228:65-69, 2005
13. Abbott CA, Carrington AL, Ashe H, Bath S, Every LC, Griffiths J, Hann AW, Hussein A, Jackson N, Johnson KE, Ryder CH, Torkington R, Van Ross ER, Whalley AM, Widdows P, Williamson S, Boulton AJ: The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabet Med 19: 377-384, 2002
14. Paisley AN, Abbott C, van Schie C, Boulton AJM: A comparison of the Neuropen against standard quantitative sensory-threshold measures for assessing peripheral nerve function. Diabet Med 19:400-405, 2002
15. Tesfaye S, Kempler P: Painful diabetic neuropathy. 48:805-807, 2005
16. Polydefkis M, Hauer P, Sheth S, Sirdofsky M, Griffin JW, McArthur JC: The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain 127:1606-1615, 2004
17. Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J, Mar- shall A, Boulton AJ, Efron N, Malik RA: Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 56:2148-2154,2007
18. Quattrini C, Jeziorska M, Boulton AJ, Malik RA: Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy. Diabetes Care 31:140-145, 2008
19. Lauria G, Morbin M, Lombardi R, Borgna M, Mazzoleni G, Sghirlanzoni A, Pareyson D: Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies. Neurology 61:631-636, 2003
20. Sorensen L, Molyneaux L, Yue DK: The relationship among pain, sensory loss, and small nerve fibers in diabetes. Diabetes Care 29:883-887, 2006
21. Loseth S, Stalberg E, Jorde R, Mellgren SI: Early diabetic neuropathy: thermal thresholds and intraepidermal nerve fibre density in patients with normal nerve conduction studies. J Neurol 255:1197-1202, 2008
22. Quattrini C, Harris ND, Malik RA, Tesfaye S: Impaired skin microvascular reactivity in painful diabetic neuropathy. Diabetes Care 30:655-659, 2007
23. Dabby R, Vaknine H, Gilad R, Djaldetti R, Sadeh M: Evaluation of cutaneous autonomic innervation in idiopathic sensory small-fiber neuropathy. J Peripher Nerv Syst 12:98-101, 2007
24. Vlckova-Moravcova E, Bednarik J, Dusek L, Toyka KV, Sommer C: Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Muscle Nerve 37:50-60, 2008
25. Lauria G, Devigili G: Skin biopsy as a diagnostic tool in peripheral neuropathy. Nat Clin Pract Neurol 3:546-557, 2007