Aspirin noncompliance is the major cause of "aspirin resistance" in patients undergoing coronary stenting

American Heart Journal

Volumn 157, Issue 5, 2009, Pages 889-893

  Cuisset, Thomas ^a,b   Frere, Corinne ^a,b   Quilici, Jacques ^a   Gaborit, Bénédicte ^a,b   Bali, Laurent ^a   Poyet, Raphaël ^a   Faille, Dorothée ^a,b   Morange, Pierre Emmanuel ^a,b   Alessi, Marie Christine ^a,b   Bonnet, Jean Louis ^a  

^a TIMONE HOSPITAL   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROSTAGLANDIN SYNTHASE;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLEEDING; CORONARY STENT; DRUG WITHDRAWAL; ENZYME INHIBITION; FEMALE; GASTROINTESTINAL SYMPTOM; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; STATISTICAL SIGNIFICANCE; STENT THROMBOSIS; THROMBOCYTE AGGREGATION; TREATMENT RESPONSE;

ACUTE CORONARY SYNDROME; AGED; ASPIRIN; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; FRANCE; GRAFT OCCLUSION, VASCULAR; HUMANS; INCIDENCE; INPATIENTS; MALE; MYOCARDIAL REVASCULARIZATION; PATIENT COMPLIANCE; PLATELET AGGREGATION INHIBITORS; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 64649091484     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2009.02.013     Document Type: Article

References (14)

1. Yusuf S., Zhao F., Mehta S.R., et al. Clopidogrel in Unstable angina to prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345 (2001) 494-502
2. Mehta S.R., Yusuf S., Peters R.J., et al. Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358 (2001) 527-533
3. Sanderson S., Emery J., Baglin T., et al. Narrative review: aspirin resistance and its clinical implications. Ann Intern Med 142 (2005) 370-380
4. Eikelboom J.W., Hirsh J., Weitz J.I., et al. Aspirin resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 105 (2002) 1650-1655
5. Gum P.A., Kottke-Marchant K., Welsh P.A., et al. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 41 (2003) 961-965
6. Chen W.H., Lee P.Y., Ng W., et al. Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment. J Am Coll Cardiol 43 (2004) 1122-1126
7. Cuisset T., Frere C., Quilici J., et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost 4 (2006) 542-549
8. Gori A.M., Marcucci R., Migliorini A., et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents. J Am Coll Cardiol 52 (2008) 734-739
9. Krasopoulos G., Brister S.J., Beattie W.S., et al. Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 336 (2008) 195-210
10. Schwartz K.A., Schwartz D.E., Ghosheh K., et al. Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction. Am J Cardiol 95 (2005) 973-975
11. Horwitz R.I., Viscoli C.M., Berkman L., et al. Treatment adherence and risk of death after a myocardial infarction. Lancet 336 (1990) 542-545
12. Gallagher E.J., Viscoli C.M., and Horwitz R.I. The relationship of treatment adherence to the risk of death after myocardial infarction in women. JAMA 270 (1993) 742-744
13. Iakovou I., Schmidt T., Bonizzoni E., et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 293 (2005) 2126-2130
14. Collet J.P., Montalescot G., Blanchet B., et al. Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes. Circulation 110 (2004) 2361-2367